| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
The aim of this study is to reveal the physiological role for de novo serine synthase in the liver in response to protein starvation. The enzymes Phgdh, Psat1 and Psph constituting the phosphorylated pathway responsible for de novo serine synthesis is shown to be induced substantially in the liver under a protein-starved nutritional condition. However, its physiological significance remains unexplored. In this study, using a liver-specific Phgdh KO mice, we examined effect of protein-free diet on metabolic homeostasis of amino acids including serine, gene/protein expression, and organ interaction, especially liver-intestine interaction.
|
