Physiological roles of liver de novo serine biosynthesis in adaptation to protein starvation
Project/Area Number |
26660116
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Food science
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Research Institution | Kyushu University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | セリン / Phgdh / リン酸化経路 / 肝臓 / 小腸 / KOマウス / タンパク質欠乏 / 低栄養 / ノックアウト / 食品 / 栄養学 / 肝機能 / タンパク質飢餓 / アミノ酸 / 腸管機能 |
Outline of Final Research Achievements |
The aim of this study is to reveal the physiological role for de novo serine synthase in the liver in response to protein starvation. The enzymes Phgdh, Psat1 and Psph constituting the phosphorylated pathway responsible for de novo serine synthesis is shown to be induced substantially in the liver under a protein-starved nutritional condition. However, its physiological significance remains unexplored. In this study, using a liver-specific Phgdh KO mice, we examined effect of protein-free diet on metabolic homeostasis of amino acids including serine, gene/protein expression, and organ interaction, especially liver-intestine interaction.
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Report
(4 results)
Research Products
(5 results)