A physiological significance of Mx1 variant
| Project/Area Number |
26660252
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Junichiro 国立研究開発法人医薬基盤, 健康・栄養研究所, 研究リーダー (60181731)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | GnRH / interferon / Mx1 / Splicing variant / composite RNA / インターフェロン / CRISPR-Cas9 System / 下垂体 / 生理学 / 細胞増殖 / コンポジットエクソン / アルタナティブスプライシング |
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| Outline of Final Research Achievements |
Mixovirus resistance 1 (Mx1) is known as a pseudogene in laboratory mouse. We found the expression of Mx1 mRNA is stimulated by GnRH and Interferon in mouse. In this project we examined the splicing variants and found a novel composite mRNA (DDBJ: LC021361). This variant consists an open reading frame. We raised anti-this variant peptide and made a knockout mouse.
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Report
(3 results)
Research Products
(19 results)
