Development of inorganic and organic reactions using stainless steel-mediated mechanochemial activation

• Project/Area Number: 26670005
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Chemical pharmacy
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: Sawama Yoshinari 岐阜薬科大学, 薬学部, 講師 (80552413)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 水素発生 / 水 / 炭化水素 / メカノケミカル / ボールミル / ステンレス / 水素 / 重水 / 水素製造 / アルカン / アンモニア / 還元

Outline of Final Research Achievements

Hydrogen is the important energy source and utilized as a reductant in organic synthesis. We have developed the effcient hydrogen generation method by the mechanochemical degradation of water or alkanes using stainless steel balls. Among the components (Fe, Cr, Ni) of stainless steel, Cr was found to be most important to degrade the water or alkanes to generate hydrogen. Ni metal could be a catalyst in the reduction of organic compounds using in situ-generated hydrogen.

Research Products

• [Journal Article] Stainless-Steel-Mediated Quantitative Hydrogen Generation from Water under Ball Milling Conditions (2015)
  • Author(s): Yoshinari Sawama, Miki Niikawa, Yuki Yabe, Ryota Goto, Takahiro Kawajiri, Takahisa Marumoto, Tohru Takahashi, Miki Itoh, Yuuichi Kimura, Yasushi Sasai, Yukinori Yamauchi, Shin-ichi Kondo,Masayuki Kuzuya, Yasunari Monguchi, and Hironao Sajiki
  • Journal Title: ASC Sustainable Chemistry Engineering Volume: 3 Issue: 4 Pages: 683-689
  • DOI: 10.1021/sc5008434
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ball milling- and stainless-steel-mediated hydrogenation (deuterogenation) using (heavy) water as a hydrogen (deuterium) source (2015)
  • Author(s): Yoshinari Sawama, Takahiro Kawajiri, Miki Niikawa, Ryota Goto, Yuki Yabe, Tohru Takahashi, Takahisa Marumoto, Miki Itoh, Yuuichi Kimura, Yasunari Monguchi, Shin-ichi Kondo and Hironao Sajiki
  • Journal Title: ChemSusChem Volume: 8 Issue: 22 Pages: 3773-3776
  • DOI: 10.1002/cssc.201501019
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Stainless steel-mediated hydrogen generation from water using ball milling and its application (2015)
  • Author(s): Yoshinari Sawama, Miki Niikawa, Takahiro Kawajiri, Ryota Goto, Yasunari Monguchi, Hironao Sajiki
  • Organizer: Pacifichem2015
  • Place of Presentation: ハワイ
  • Year and Date: 2015-12-15 – 2015-12-20
• [Presentation] Stainless steel-mediated hydrogen generation from water using ball milling and its application (2015)
  • Author(s): Yoshinari Sawama, Miki Niikawa, Takahiro Kawajiri, Ryota Goto, Yasunari Monguchi, Hironao Sajiki
  • Organizer: Pacifichem2015
  • Place of Presentation: Hawaii
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] 有機分子を水素源としたメカノケミカル的水素発生法と還元反応への応用 (2014)
  • Author(s): 後藤諒太、澤間善成、新川美紀、本田彬恵、門口泰也、佐治木弘尚
  • Organizer: 第４０回反応と合成の進歩シンポジウム
  • Place of Presentation: 東北大学 川内萩ホール
  • Year and Date: 2014-11-10 – 2014-11-11
• [Remarks] 岐阜薬科大学 創薬化学大講座 薬品化学研究室
  • URL: http://sv1.gifu-pu.ac.jp/lab/yakuhin/