| Project/Area Number |
26670117
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
YANAI Kazuhiko 東北大学, 医学(系)研究科(研究院), 教授 (50192787)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Takehiko 東北大学, 大学院医学系研究科, 名誉教授 (70028356)
YOSHIKAWA Takeo 東北大学, 大学院医学系研究科, 助教 (70506633)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | ヒスタミン / HNMT / PMAT / ノックアウトマウス |
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| Outline of Final Research Achievements |
Histamine plays an important role in brain functions such as sleep-wake cycle and stress response. We investigated the molecular mechanism of histamine clearance. We demonstrated that histamine N-methyltransferase, which inactivates histamine, was one of the essential factors for histamine clearance.
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