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Regeneration of Elastic Fiber

Research Project

Project/Area Number 26670147
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionKansai Medical University

Principal Investigator

NAKAMURA Tomoyuki  関西医科大学, 医学部, 教授 (20362527)

Co-Investigator(Renkei-kenkyūsha) KAGESHIMA Masami  関西医科大学, 医学部, 教授 (90251355)
KUSUMOTO Kenji  関西医科大学, 医学部, 教授 (20161630)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords細胞外マトリックス / 弾性線維
Outline of Final Research Achievements

Elastic fiber is an extracellular matrix component that plays a key role in tissue elasticity. Degradation of elastic fibers directly causes skin looseness, emphysema, and arteriosclerosis. The turnover rate of elastic fiber is extremely slow, and there have been no method to regenerate elastic fibers so far. We have identified several proteins that play crucial roles in elastogenesis, and notably one of them could induce elastogenesis in cell culture. In this study, we engineered an assay system to measure mechanical characteristics of the extracellular matrix produced by cultured cells in order to analyze how elatogenic factors affect the elasticity of the matrix, with the goal of finding optimal condition for elastic fiber regeneration.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2015 2014

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results)

  • [Journal Article] The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.2015

    • Author(s)
      Nakasaki M, Hwang Y, Xie Y, Kataria S, Gund R, Hajam EY, Samuel R, George R, Danda D, M J P, Nakamura T, Shen Z, Briggs S, Varghese S, Jamora C
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 8574-8574

    • DOI

      10.1038/ncomms9574

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice.2015

    • Author(s)
      Noda K, Nakamura T, Komatsu Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 466 Issue: 3 Pages: 585-591

    • DOI

      10.1016/j.bbrc.2015.09.089

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regeneration of elastic fibers by three-dimensional culture on a collagen scaffold and the addition of latent TGF-β binding protein 4 to improve elastic matrix deposition.2015

    • Author(s)
      Aya R, Ishiko T, Noda K, Yamawaki S, Sakamoto Y, Tomihata K, Katayama Y, Yoshikawa K, Kubota H, Nakamura T, Naitoh M, Suzuki S
    • Journal Title

      Biomaterials

      Volume: 72 Pages: 29-37

    • DOI

      10.1016/j.biomaterials.2015.08.036

    • NAID

      120005753831

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth.2015

    • Author(s)
      Fanhchaksai K, Okada F, Nagai N, Pothacharoen P, Kongtawelert P, Hatano S, Makino S, Nakamura T and Watanabe H
    • Journal Title

      International Journal of Cancer

      Volume: 138 Issue: 3 Pages: 630-641

    • DOI

      10.1002/ijc.29804

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modeling autosomal recessive cutis laxa type 1C (ARCL1C) in mice reveals distinct functions of Ltbp-4 isoforms.2015

    • Author(s)
      Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A
    • Journal Title

      Disease Models and Mechanisms

      Volume: 8 Pages: 403-415

    • DOI

      10.1242/dmm.018960

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exploring the origin and limitations of kidney regeneration.2015

    • Author(s)
      Endo T, Nakamura J, Sato Y, Asada M, Yamada R, Takase M, Takaori K, Oguchi A, Iguchi T, Higashi AY, Ohbayashi T, Nakamura T, Muso E, Kimura T, Yanagita M.
    • Journal Title

      J Pathol.

      Volume: 236(2) Issue: 2 Pages: 251-63

    • DOI

      10.1002/path.4514

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latent TGFβ binding protein-2 is essential for the development of ciliary zonule microfibrils.2014

    • Author(s)
      Inoue T., Ohbayashi T., Fujikawa Y., Yoshida H., Akama T.O., Noda K., Horiguchi M., Kameyama K., Hata Y., Takahashi K., Kusumoto K. and Nakamura T.
    • Journal Title

      Human Molecular Genetics

      Volume: 23 Issue: 21 Pages: 5672-5682

    • DOI

      10.1093/hmg/ddu283

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling.2014

    • Author(s)
      Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
    • Journal Title

      Circulation.

      Volume: 129 Issue: 4 Pages: 487-496

    • DOI

      10.1161/circulationaha.113.004726

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.2014

    • Author(s)
      Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 5312-5312

    • DOI

      10.1038/srep05312

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 弾性線維形成に必須のLTBP-4の役割2014

    • Author(s)
      中邨智之
    • Journal Title

      生化学

      Volume: 86 Pages: 770-773

    • NAID

      40020314156

    • Related Report
      2014 Research-status Report
  • [Presentation] TGFβに依存しないLTBPsの機能2015

    • Author(s)
      中邨智之
    • Organizer
      日本エラスチン研究会
    • Place of Presentation
      アルカディア市ヶ谷、東京都
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 弾性線維形成因子が関与する多臓器疾患2015

    • Author(s)
      中邨智之
    • Organizer
      第35回日本サルコイドーシス/肉芽腫性疾患学会総会
    • Place of Presentation
      ホテルエルセラーン大阪、大阪市
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] TGFβ-independent role of LTBPs in microfibril and elastic fiber assembly, and molecular function of Fibulin-4.2015

    • Author(s)
      Tomoyuki Nakamura
    • Organizer
      Gordon Research Conference on Elastin and Elastic Fiber
    • Place of Presentation
      University of New England、米国Biddeford市、メイン州
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 動脈の硬さを規定する細胞外マトリックス2015

    • Author(s)
      中邨智之
    • Organizer
      第47回日本動脈硬化学会学術集会
    • Place of Presentation
      仙台国際センター、仙台市
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] LTBP-2とLTBP-4は弾性線維形成において重複する機能を有する2015

    • Author(s)
      吉田秀之、藤川雄介、井上唯史、赤間智也、中邨智之
    • Organizer
      第47回日本結合組織学会学術集会
    • Place of Presentation
      コクヨホール、東京都
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 動脈弾性板形成の分子機構2014

    • Author(s)
      中邨智之
    • Organizer
      第51回血管研究会
    • Place of Presentation
      東京医科歯科大学
    • Year and Date
      2014-10-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 生体の伸縮性を生み出すしくみ ~弾性線維の形成と再生の分子機構~2014

    • Author(s)
      中邨智之
    • Organizer
      第65回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      大阪ナレッジキャピタルコングレコンベンションセンター
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 弾性線維の形成と再生の分子機構2014

    • Author(s)
      中邨智之
    • Organizer
      佐島シンポジウム
    • Place of Presentation
      京都大学
    • Year and Date
      2014-10-10
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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