| Project/Area Number |
26670147
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KAGESHIMA Masami 関西医科大学, 医学部, 教授 (90251355)
KUSUMOTO Kenji 関西医科大学, 医学部, 教授 (20161630)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞外マトリックス / 弾性線維 |
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| Outline of Final Research Achievements |
Elastic fiber is an extracellular matrix component that plays a key role in tissue elasticity. Degradation of elastic fibers directly causes skin looseness, emphysema, and arteriosclerosis. The turnover rate of elastic fiber is extremely slow, and there have been no method to regenerate elastic fibers so far. We have identified several proteins that play crucial roles in elastogenesis, and notably one of them could induce elastogenesis in cell culture. In this study, we engineered an assay system to measure mechanical characteristics of the extracellular matrix produced by cultured cells in order to analyze how elatogenic factors affect the elasticity of the matrix, with the goal of finding optimal condition for elastic fiber regeneration.
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