New approach to develop Lactosome-based therapy for allergic disease

• Project/Area Number: 26670155
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: University of Fukui
• Principal Investigator: Sugai Manabu 福井大学, 学術研究院医学系部門, 教授 (90303891)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ラクトソーム / IgE / TGF-b / レチノイン酸 / TGF-beta / IgA / TGF-b1

Outline of Final Research Achievements

Allergic hypersensitivity disorders are characterized by an excessive immunoglobulin E (IgE) response. IgE stimulates basophils and mast cells to release biologically active mediators in an antigen-specific manner. Steroids is commonly used for treatment of allergic disease to dampen inflammatory response. However, steroids also inhibit useful immune reaction. In this project, we try to develop new therapy for allergic disease by reducing IgE in vivo. For this purpose, we used “Lactosome” as a drug-delivery carrier.

Research Products

• [Journal Article] Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis. (2016)
  • Author(s): Saito K., Takahashi K., Asahara M., Kiso H., Togo Y., Tsukamoto H., Huang B., Sugai M., Shimizu A., Motokawa M., Slavkin HC., Bessho K.
  • Journal Title: BMC Dev Biol. Volume: 16 Issue: 1 Pages: 14-23
  • DOI: 10.1186/s12861-016-0117-x
  • NAID: 120005819500
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development. (2016)
  • Author(s): Togo Y., Takahashi K., Saito K., Kiso H., Tsukamoto H., Huang B., Yanagita M., Sugai M., Harada H., Komori T., Shimizu A., MacDougall M., Bessho K.
  • Journal Title: PLoS One Volume: 11 Issue: 8 Pages: e0161067-e0161067
  • DOI: 10.1371/journal.pone.0161067
  • NAID: 120005842696
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Activation of B1a Cells in Peritoneal Cavity by T Cell-Independent Antigen Expressed on Polymeric Micelle (2015)
  • Author(s): Cheol Joo Kim1, Eri Hara2, Akira Shimizu2, Manabu Sugai2 and Shunsaku Kimura1*
  • Journal Title: Journal of Pharmaceutical Sciences Volume: 104 Issue: 5 Pages: 1839-1847
  • DOI: 10.1002/jps.24397
  • Peer Reviewed / Open Access
• [Journal Article] Prospective signs of cleidocranial dysplasia in Cebpb deficiency (2014)
  • Author(s): Boyen Huang1,2, Katsu Takahashi2*, Ernest A Jennings1 , Pongthorn Pumtang-on3 , Honoka Kiso2 , Yumiko Togo2 , Kazuyuki Saito2 , Manabu Sugai4 , Shizuo Akira5 , Akira Shimizu4 and Kazuhisa Bessho2
  • Journal Title: Journal of Biomedical Science Volume: 21 Issue: 1 Pages: 44-48
  • DOI: 10.1186/1423-0127-21-44
  • Peer Reviewed / Open Access
• [Journal Article] Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations (2014)
  • Author(s): Honoka Kiso, Katsu Takahashi , Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Yasuhiko Tabata, Aris N. Economides, Harold C. Slavkin, Kazuhisa Bessho
  • Journal Title: PlosOne Volume: 9 Issue: 5 Pages: 96938-96944
  • DOI: 10.1371/journal.pone.0096938
  • Peer Reviewed / Open Access
• [Presentation] T cell independent immune response against “Lactosome” (2014)
  • Author(s): HARA Eri1, KIM Cheol Joo2, SUGAI Manabu1, KIMURA Shunsaku2
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2014-12-10 – 2014-12-12