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New approach to develop Lactosome-based therapy for allergic disease

Research Project

Project/Area Number 26670155
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionUniversity of Fukui

Principal Investigator

Sugai Manabu  福井大学, 学術研究院医学系部門, 教授 (90303891)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsラクトソーム / IgE / TGF-b / レチノイン酸 / TGF-beta / IgA / TGF-b1
Outline of Final Research Achievements

Allergic hypersensitivity disorders are characterized by an excessive immunoglobulin E (IgE) response. IgE stimulates basophils and mast cells to release biologically active mediators in an antigen-specific manner. Steroids is commonly used for treatment of allergic disease to dampen inflammatory response. However, steroids also inhibit useful immune reaction. In this project, we try to develop new therapy for allergic disease by reducing IgE in vivo. For this purpose, we used “Lactosome” as a drug-delivery carrier.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (1 results)

  • [Journal Article] Effects of Usag-1 and Bmp7 deficiencies on murine tooth morphogenesis.2016

    • Author(s)
      Saito K., Takahashi K., Asahara M., Kiso H., Togo Y., Tsukamoto H., Huang B., Sugai M., Shimizu A., Motokawa M., Slavkin HC., Bessho K.
    • Journal Title

      BMC Dev Biol.

      Volume: 16 Issue: 1 Pages: 14-23

    • DOI

      10.1186/s12861-016-0117-x

    • NAID

      120005819500

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antagonistic Functions of USAG-1 and RUNX2 during Tooth Development.2016

    • Author(s)
      Togo Y., Takahashi K., Saito K., Kiso H., Tsukamoto H., Huang B., Yanagita M., Sugai M., Harada H., Komori T., Shimizu A., MacDougall M., Bessho K.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 8 Pages: e0161067-e0161067

    • DOI

      10.1371/journal.pone.0161067

    • NAID

      120005842696

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of B1a Cells in Peritoneal Cavity by T Cell-Independent Antigen Expressed on Polymeric Micelle2015

    • Author(s)
      Cheol Joo Kim1, Eri Hara2, Akira Shimizu2, Manabu Sugai2 and Shunsaku Kimura1*
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 104 Issue: 5 Pages: 1839-1847

    • DOI

      10.1002/jps.24397

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective signs of cleidocranial dysplasia in Cebpb deficiency2014

    • Author(s)
      Boyen Huang1,2, Katsu Takahashi2*, Ernest A Jennings1 , Pongthorn Pumtang-on3 , Honoka Kiso2 , Yumiko Togo2 , Kazuyuki Saito2 , Manabu Sugai4 , Shizuo Akira5 , Akira Shimizu4 and Kazuhisa Bessho2
    • Journal Title

      Journal of Biomedical Science

      Volume: 21 Issue: 1 Pages: 44-48

    • DOI

      10.1186/1423-0127-21-44

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations2014

    • Author(s)
      Honoka Kiso, Katsu Takahashi , Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Manabu Sugai, Akira Shimizu, Yasuhiko Tabata, Aris N. Economides, Harold C. Slavkin, Kazuhisa Bessho
    • Journal Title

      PlosOne

      Volume: 9 Issue: 5 Pages: 96938-96944

    • DOI

      10.1371/journal.pone.0096938

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] T cell independent immune response against “Lactosome”2014

    • Author(s)
      HARA Eri1, KIM Cheol Joo2, SUGAI Manabu1, KIMURA Shunsaku2
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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