Development of immunopathologic diagnosis with a new transition marker of follicular helper T cells
Project/Area Number |
26670178
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
HIMI Tetsuo 札幌医科大学, 医学部, 教授 (90181114)
SATO Noriyuki 札幌医科大学, 医学部, 名誉教授 (50158937)
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Research Collaborator |
KAWATA Koji
KAMEKURA Rhyuta
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 濾胞ヘルパーT細胞 / 免疫組織化学 / 免疫病理学 / 病理診断学 / 免疫関連疾患 / 濾胞ヘルパーT細胞サブセット / ナイーブヘルパーT細胞 / 病理組織診断 / リンパ腫 / 炎症性疾患 / 制御性B細胞 / 血液 / 免疫アレルギー疾患 / アレルギー性鼻炎 / 気管支喘息 / 病理診断 |
Outline of Final Research Achievements |
In this study, we performed functional analysis of T follicular helper (Tfh) cells and their transitional cell subsets to apply novel findings for histopathological examinations of immune-related disorders. As a result, we found high expression of a Bob1 transcription factor in Tfh cells and the involvement of Bob1 in the regulation of cell numbers of Tfh cells (Eur J Immunol. 2016). Further, we revealed that Tfh2-cell polarization preferentially occurred in the patients with allergic asthma and allergic rhinitis, as seen as Th2-cell polarization in the patients(Clin Immunol. 2015). This implies the common mechanism underlying Tfh2-cell and Th2-cell polarization, suggesting that a manner of skewing of Tfh-cell subset would reflect a disease-specific feature of helper CD4(+) T cells. By virtue of a characteristic molecule(s) in Tfh cells and Tfh-cell subsets, further studies might lead to a new modality for histopathological diagnosis of immune-related disorders.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Bob1 limits cellular frequency of T follicular helper cells2016
Author(s)
Yamashita K, Kawata K, Matsumiya H, Kamekura R, Jitsukawa S, Nagaya T, Ogasawara N, Takano K, Kubo T, Kimura S, Shigehara K, Himi T, Ichimiya S.
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Journal Title
European Journal of Immunology
Volume: in press
Issue: 6
Pages: 1361-1370
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of a novel human memory T cell population with the characteristics of stem-like chemo-resistance2016
Author(s)
Murata K, Tsukahara T, Matsumiya H, Yamashita K, Kaya M, Hirohashi Y, Kanaseki T, Kubo T, Himi T, Ichimiya S, Yamashita T, Sato N, Torigoe T.
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Journal Title
Oncoimmunology
Volume: in press
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Role of Crosstalk between Epithelial and Immune Cells, the Epimmunome, in Allergic Rhinitis Pathogenesis2016
Author(s)
Kamekura R, Yamashita K, Jitsukawa S, Nagaya T, Ito F, Ichimiya S, Himi, T.
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Journal Title
70th Anniversary: Department of ORL, Sapporo Medical University Advances in Oto-Rhino-Laryngology
Volume: 77
Pages: 75-82
Related Report
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[Journal Article] Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma2015
Author(s)
Kamekura R, Shigehara K, Miyajima S, Jitsukawa S, Kawata K, Yamashita K, Nagaya T, Kumagai A, Sato A, Matsumiya H, Ogasawara N, Seki N, Takano K, Kokai Y, Takahashi H, Himi T, Ichimiya S
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Journal Title
Clinical Immunology
Volume: in press
Issue: 2
Pages: 120-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis.2014
Author(s)
Kubo T, Kamekura R, Kumagai A, Kawata K, Yamashita K, Mitsuhashi Y, Kojima T, Sugimoto K, Yoneta A, Sumikawa Y, Yamashita T, Sato N, Himi T, Ichimiya S
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Journal Title
PLoS One
Volume: 9(8)
Issue: 8
Pages: e105498-e105498
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody.2014
Author(s)
Tsukahara T, Emori M, Murata K, Hirano T, Muroi N, Kyono M, Toji S, Watanabe K, Torigoe T, Kochin V, Asanuma H, Matsumiya H, Yamashita K, Himi T, Ichimiya S, Wada T, Yamashita T, Hasegawa T, Sato N.
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Journal Title
J Biol Chem
Volume: 289
Issue: 32
Pages: 22035-22047
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] POU2AF1 arranges systemic distribution of follicular helper T cells.2014
Author(s)
Yamashita K, Mitsuhashi Y, Nagaya T, Jitsukawa S, Kamekura R, Seki N, Kumagai A, Kawata K, Himi T, Ichimiya S.
Organizer
Immunology 2014, AAI Annual Meeting
Place of Presentation
Pittsburgh, USA
Year and Date
2014-05-02 – 2014-05-06
Related Report
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