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Novel signaling pathway of bacterial stress responses and host defense via autophagy

Research Project

Project/Area Number 26670207
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bacteriology (including mycology)
Research InstitutionTohoku University

Principal Investigator

AKAIKE Takaaki  東北大学, 医学系研究科, 教授 (20231798)

Co-Investigator(Kenkyū-buntansha) MATSUNAGA Tetsuro  東北大学, 大学院医学系研究科, 助教 (00723206)
IDA Tomoaki  東北大学, 大学院医学系研究科, 助教 (70570406)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords細菌 / シグナル伝達 / オートファジー / 活性酸素 / レドックス
Outline of Final Research Achievements

To clarify the molecular mechanism of pathogenesis of bacterial infection, we investigated the functions of 8-nitro-cGMP which is a signaling molecule both in bacteria and host cells. Protein S-guanylation induced by 8-nitro-cGMP was involved in stress responses in bacteria, and also play an important role in antibacterial host defense via autophagy. Hydrogen sulfide and reactive sulfur species produced by bacteria were suggested to regulate signaling function of 8-nitro-cGMP and to be involved in bacterial growth in infected cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (79 results)

All 2016 2015 2014 Other

All Journal Article (32 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 22 results,  Open Access: 17 results,  Acknowledgement Compliant: 7 results) Presentation (44 results) (of which Int'l Joint Research: 4 results,  Invited: 21 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Persistent activation of cGMP-dependent protein kinase by a nitrated cyclic nucleotide via site specific protein S-guanylation2016

    • Author(s)
      Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T.
    • Journal Title

      Biochemistry

      Volume: 55 Issue: 5 Pages: 751-761

    • DOI

      10.1021/acs.biochem.5b00774

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by electrophiles and reactive sulfur species2016

    • Author(s)
      Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 58 Issue: 2 Pages: 91-98

    • DOI

      10.3164/jcbn.15-111

    • NAID

      130005132519

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides2016

    • Author(s)
      Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.
    • Journal Title

      Arch Biochem Biophys

      Volume: 595 Pages: 140-146

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reactive sulfur species-mediated activation of the Keap1-Nrf2 pathway by 1,2-napthoquinone through sulfenic acids formation under oxidative stress.2015

    • Author(s)
      Shinkai Y, Abiko Y, Ida T, Miura T, Kakehashi H, Ishii I, Nishida M, Sawa T, Akaike T, Kumagai Y.
    • Journal Title

      Chem Res Toxicol.

      Volume: 印刷中 Issue: 5 Pages: 838-847

    • DOI

      10.1021/tx500416y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Involvement of reactive persulfides in biological bismethylmercury sulfide formation.2015

    • Author(s)
      Abiko Y, Yoshida E, Ishii I, Fukuto JM, Akaike T, Kumagai Y.
    • Journal Title

      Chemical Research in Toxicology.

      Volume: 28 Issue: 6 Pages: 1301-1306

    • DOI

      10.1021/acs.chemrestox.5b00101

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 8-Mercapto-cyclic GMP mediates hydrogen sulfide-induced stomatal closure in Arabidopsis.2015

    • Author(s)
      Honda K, Yamada N, Yoshida R, Ihara H, Sawa T, Akaike T, Iwai S.
    • Journal Title

      Plant Cell Physiol.

      Volume: 56 Issue: 8 Pages: 1481-1489

    • DOI

      10.1093/pcp/pcv069

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.2015

    • Author(s)
      Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M.
    • Journal Title

      J Mol Med (Berl).

      Volume: 印刷中 Issue: 8 Pages: 879-889

    • DOI

      10.1007/s00109-015-1271-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides.2015

    • Author(s)
      Abiko Y., Ishii I., Kamata S., Tsuchiya Y., Watanabe Y., Ihara H., Akaike T., Kumagai Y.
    • Journal Title

      Chem. Res. Toxicol.

      Volume: 28 Issue: 9 Pages: 1796-1802

    • DOI

      10.1021/acs.chemrestox.5b00245

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP252015

    • Author(s)
      K. Kunieda, H. Tsutsuki, T. Ida, Y. Kishimoto, S. Kasamatsu, T. Sawa, N. Goshima, M. Itakura, M. Takahashi, T. Akaike, H. Ihara
    • Journal Title

      ACS Chemical Neuroscience

      Volume: 6 Issue: 10 Pages: 1715-1725

    • DOI

      10.1021/acschemneuro.5b00196

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia2015

    • Author(s)
      Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F
    • Journal Title

      J Am Heart Assoc

      Volume: 4 Issue: 11

    • DOI

      10.1161/jaha.115.002125

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Development of Fluorescent Probes for Visualizing Intracellular Hydrogen Polysulfides2015

    • Author(s)
      Wei Chen, Ethan W. Rosser, Tetsuro Matsunaga, Armando Pacheco, Takaaki Akaike, and Ming Xian
    • Journal Title

      Angewandte Chemie - International Edition

      Volume: 54 Issue: 47 Pages: 13961-13965

    • DOI

      10.1002/anie.201506887

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Chemical Biology of Hydropersulfides (RSSH): Chemical Stability, Reactivity and Redox Roles.2015

    • Author(s)
      Saund, S. S., Sosa, V., Henriquez, S., Nguyen, Q. N. N., Soeda, S., Bianco, C. L., Millikin, R., White, C., Le, H., Ono, K., Tantillo, D. J., Kumagai, Y., Akaike, T., Lin, J., Fukuto, J. M.
    • Journal Title

      Arch. Biochem. Biophys.

      Volume: 588 Pages: 15-24

    • DOI

      10.1016/j.abb.2015.10.016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 感染性微生物:H. cinaedi2015

    • Author(s)
      松永哲郎、藤井重元、赤池孝章.
    • Journal Title

      動脈硬化予防

      Volume: 14 Pages: 66-71

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 活性イオウ分子による酸化・ニトロ化ストレス制御2015

    • Author(s)
      笠松真吾、井田智章、藤井重元、赤池孝章.
    • Journal Title

      Respiratory Medical Research

      Volume: 3 Pages: 70-75

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 活性イオウ分子種による酸化ストレス制御2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 63 Pages: 502-506

    • NAID

      40020484751

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Host defense and oxidative stress signaling in bacterial infection2015

    • Author(s)
      赤池孝章.
    • Journal Title

      Nippon Saikingaku Zasshi

      Volume: 70 Issue: 3 Pages: 339-349

    • DOI

      10.3412/jsb.70.339

    • NAID

      130005094695

    • ISSN
      0021-4930, 1882-4110
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nitric Oxide (NO)2015

    • Author(s)
      赤池孝章、藤井重元.
    • Journal Title

      生体の科学

      Volume: 66 Pages: 396-397

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Mesenchymal Stem Cells Correct Inappropriate Epithelial-mesenchyme Relation in Pulmonary Fibrosis Using Stanniocalcin-1.2015

    • Author(s)
      Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, Nukiwa T, Irokawa T, Ogawa H, Akaike T, Okada Y, Kurosawa H, Kikuchi T, Ichinose M.
    • Journal Title

      Mol Ther

      Volume: 23 Issue: 3 Pages: 549-560

    • DOI

      10.1038/mt.2014.217

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] H2Sの生体内生成とシグナル機能の正体:システインパースルフィドの再発見と新機能2015

    • Author(s)
      赤池孝章.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 346-348

    • Related Report
      2014 Research-status Report
  • [Journal Article] RSSによる抗酸化・レドックスシグナル制御2015

    • Author(s)
      井田智章、藤井重元、赤池孝章.
    • Journal Title

      細胞工学

      Volume: 34 Pages: 354-357

    • Related Report
      2014 Research-status Report
  • [Journal Article] Redox signal regulation via nNOS phosphorylation at Ser847 in PC12 cells and rat cerebellar granule neurons.2014

    • Author(s)
      Kasamats S, Watanabe Y, Sawa T, Akaike T, Ihara H.
    • Journal Title

      Biochem. J.

      Volume: 459 Issue: 2 Pages: 251-263

    • DOI

      10.1042/bj20131262

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014

    • Author(s)
      Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
    • Journal Title

      Cell Metab.

      Volume: 9 Issue: 4 Pages: 712-721

    • DOI

      10.1016/j.cmet.2014.03.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.2014

    • Author(s)
      Khan S, Rahman H N A, Okamoto T, Matsunaga T, Fujiwara Y, Sawa T, Yoshitake J, Ono K, Ahmed K A, Rahaman M d M, Oyama K, Takeya M, Ida T, Kitamura Y, Fujii S, Akaike T.
    • Journal Title

      Sci. Rep.

      Volume: (印刷中) Issue: 1 Pages: 4680-4680

    • DOI

      10.1038/srep04680

    • NAID

      120005649608

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014

    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: (印刷中) Issue: 21 Pages: 7606-7611

    • DOI

      10.1073/pnas.1321232111

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of 8-nitro-cGMP and its redox regulation in cardiovascular electrop hilic signaling2014

    • Author(s)
      Nishida M, Toyama T and Akaike T
    • Journal Title

      J Mol Cell Cardiol

      Volume: (In press) Pages: 10-17

    • DOI

      10.1016/j.yjmcc.2014.02.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical and bacteriological characteristics of Helicobacter cinaedi infection2014

    • Author(s)
      Kawamura Y, Tomida J, Morita Y, Fujii S, Okamoto T, Akaike T.
    • Journal Title

      J Infect Chemother

      Volume: 20 Issue: 9 Pages: 517-526

    • DOI

      10.1016/j.jiac.2014.06.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The redox chemistry and chemical biology of H2S, hydropersulfides and derivaed species: implications to their possible biological activity and utility.2014

    • Author(s)
      Ono, K., Akaike T., Sawa, T., Kumagai, Y., Wink, D. A., Tantillo, D. J., Hobbs, A. J., Nagy, P., Xian, M., Lin, J., Fukuto, J.
    • Journal Title

      Free Radic. Biol. Med.

      Volume: 77 Pages: 82-94

    • DOI

      10.1016/j.freeradbiomed.2014.09.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Helicobacter cinaedi meningitis: a case report and review of previous cases.2014

    • Author(s)
      Okubo H, Goto M, Sato M, Sugiyama T, Kawano M, Matsunaga T, Akaike T.
    • Journal Title

      J Neurol Sci.

      Volume: 347 Issue: 1-2 Pages: 396-397

    • DOI

      10.1016/j.jns.2014.10.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 活性酸素による多階層シグナル伝達機構とレドックス恒常性制御2014

    • Author(s)
      赤池孝章.
    • Journal Title

      Yakugaku Zasshi

      Volume: 134 Pages: 515-519

    • NAID

      130003391199

    • Related Report
      2014 Research-status Report
  • [Journal Article] 活性酸素と炎症2014

    • Author(s)
      井田智章、赤池孝章、澤 智裕、藤井重元.
    • Journal Title

      感染・炎症・免疫

      Volume: 44 Pages: 104-109

    • Related Report
      2014 Research-status Report
  • [Journal Article] システインパースルフィドの生体内生成と生理機能の再発見:活性イオウ分子による抗酸化・レドックスシグナル制御2014

    • Author(s)
      赤池孝章.
    • Journal Title

      実験医学

      Volume: 32 Pages: 2123-2126

    • Related Report
      2014 Research-status Report
  • [Journal Article] フリーラジカル制御系:硫化水素・活性イオウ分子と炎症2014

    • Author(s)
      藤井重元、井田智章、澤 智裕、赤池孝章.
    • Journal Title

      実験医学

      Volume: 32 Pages: 2803-2809

    • Related Report
      2014 Research-status Report
  • [Presentation] ニトロ化環状ヌクレオチドによる感染防御機構と細菌由来硫化水素による制御2016

    • Author(s)
      藤井重元、井田智章、松永哲郎、赤池孝章.
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌市教育文化会館、ホテルロイトン札幌、札幌コンベンションセンター、札幌市産業振興センター(札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性イオウ分子種の生体内生成と生理機能2016

    • Author(s)
      赤池孝章.
    • Organizer
      日本薬学会 第136年会
    • Place of Presentation
      パシフィコ横浜(横浜市西区)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オートファジーによる細菌感染防御機構と細菌由来硫化水素による制御2016

    • Author(s)
      藤井重元、松永哲郎、シャザダ カーン、モハメド ミザヌール ラハマン、井田智章、小野勝彦、澤 智裕、赤池孝章.
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪市天王寺区)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細菌の新しいシグナル伝達物質:8-ニトロ-cGMPの生成と機能解析.2016

    • Author(s)
      井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪市天王寺区)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 健常者における新興感染症菌 Helicobacter cinaedi 感染スクリーニングと感染疫学研究2016

    • Author(s)
      松永哲郎、藤井重元、井田智章、津々木博康、澤 智裕、河村好章、赤池孝章.
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪市天王寺区)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性システインパースルフィドの生合成機構とレドックス制御機能2016

    • Author(s)
      赤池孝章.
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 会議センター(横浜市西区)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Polysulfides and Redox Signaling.2016

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 2016 Oxygen Radicals Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott(Ventura, CA, USA)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of metabolome analysis for reactive sulfur species2016

    • Author(s)
      Ida T, Kasamatsu S, Fujii S, Sawa T, Ihara H, Akaike T.
    • Organizer
      The 2016 Oxygen Radicals Gordon Research Conference
    • Place of Presentation
      Ventura Beach Marriott(Ventura, CA, USA)
    • Year and Date
      2016-02-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論2016

    • Author(s)
      赤池孝章.
    • Organizer
      平成27年度 学校法人北里研究所 第25回学会受賞者特別講演会
    • Place of Presentation
      北里大学白金キャンパス薬学部コンベンションホール(東京都港区)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Antioxidant Electrophilic Signaling Regulated by Reactive Sulfur Species and Its Translational Biosynthesis2015

    • Author(s)
      赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] タンパク質ポリサルファ化の分子メカニズムの解明2015

    • Author(s)
      井田智章、居原 秀、魏 范研、富澤一仁、長尾翌手可、鈴木 勉、熊谷嘉人、澤 智裕、笠松真吾、本橋ほづみ、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規活性イオウ分子過硫化水素(HSSH)の生体内生成の検出と生成機序の解明2015

    • Author(s)
      松永哲郎、井田智章、藤井重元、渡邊泰男、澤 智裕、本橋ほづみ、Ming Xian、赤池孝章.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市中央区)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein-Bound Reactive Sulfur Species and Its Translational Biosynthesis: Potential Implication for Oxidative Stress and Tumor Biology2015

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 46th International Symposium of The Princess Takamatsu Cancer Research Fund
    • Place of Presentation
      パレスホテル東京(東京都千代田区)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 8-ニトロ-cGMPとタンパク質S-グアニル化を介する細菌感染防御機構と硫化水素による制御2015

    • Author(s)
      藤井重元、シャザダ カーン、ムハマド ミザヌール ラハマン、松永哲郎、井田智章、小野勝彦、赤池孝章.
    • Organizer
      第21回MPO研究会
    • Place of Presentation
      慶應義塾大学病院2号棟11階中会議室(東京都新宿区)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新興感染症菌 Helicobacter cinaedi の持続感染と動脈硬化促進のメカニズムの解明2015

    • Author(s)
      松永哲郎、藤井重元、井田智章、小野勝彦、津々木博康、澤 智裕、河村好章、赤池孝章.
    • Organizer
      第21回MPO研究会
    • Place of Presentation
      慶應義塾大学病院2号棟11階中会議室(東京都新宿区)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Reactive persulfide species: Its antioxidant redox signaling and translational biosynthesis2015

    • Author(s)
      Takaaki Akaike.
    • Organizer
      文部科学省 私立大学戦略的研究基盤形成支援事業 生体分子コバレント修飾の革新的解析拠点形成 第2回国際シンポジウム New Aspects of Covalent modifications from Small to Large Molecules.
    • Place of Presentation
      昭和薬科大学(東京都町田市)
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新興感染症菌 Helicobacter cinaedi の感染拡大と動脈硬化症の進展・促進作用2015

    • Author(s)
      松永哲郎、藤井重元、井田智章、小野勝彦、津々木博康、澤 智裕、河村好章、赤池孝章.
    • Organizer
      第69回日本細菌学会東北支部総会
    • Place of Presentation
      郡山ビッグアイ(福島県郡山市)
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 活性イオウ分子システインパースルフィドのタンパク質翻訳機構:タンパク質ポリチオール化2015

    • Author(s)
      赤池孝章.
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川県音楽堂、金沢市アートホール、ホテル日航金沢(石川県金沢市)
    • Year and Date
      2015-06-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドのメタボロームおよびプロテオーム解析2015

    • Author(s)
      井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第15回日本NO学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] システインパースルフィドの新しいタンパク質翻訳機構:タンパク質ポリチオール化2015

    • Author(s)
      赤池孝章.
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわ銀ホール(徳島市)
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性酸素のシグナル伝達機構の解明2015

    • Author(s)
      赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 活性システインパースルフィドのメタボロミクスとプロテオミクス2015

    • Author(s)
      井田智章、居原 秀、澤 智裕、土屋幸弘、渡邊泰男、藤井重元、熊谷嘉人、本橋ほづみ、赤池孝章.
    • Organizer
      第68回日本酸化ストレス学会学術集会
    • Place of Presentation
      かごしま県民交流センター(鹿児島市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 細菌感染における酸化ストレスシグナル制御と感染防御論(浅川賞受賞講演)2015

    • Author(s)
      赤池孝章.
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Helicobacter cinaedi感染による動脈硬化促進作用と感染疫学2015

    • Author(s)
      松永哲郎、藤井重元、井田智章、河村好章、赤池孝章.
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 活性イオウ含有分子の再発見とその生物活性2015

    • Author(s)
      井田智章、赤池孝章.
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Redox-active cysteine polysulfide modulates NO and electrophilic protein modification2015

    • Author(s)
      Takaaki Akaike.
    • Organizer
      The 2015 Nitric Oxide Gordon Research Conference
    • Place of Presentation
      Four Points Sheraton/Holiday Inn Express (Ventura, CA, USA)
    • Year and Date
      2015-02-15 – 2015-02-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 活性イオウ分子とADH3によるホルムアルデヒド解毒代謝機構2015

    • Author(s)
      井田智章、Md. Morshedul Alam、松永哲郎、藤井重元、居原 秀、本橋ほづみ、赤池孝章.
    • Organizer
      第14回分子予防環境医学研究会
    • Place of Presentation
      大阪市立大学医学部(大阪市阿倍野区)
    • Year and Date
      2015-02-13 – 2015-02-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症・酸化ストレス応答とフリーラジカル・活性酸素制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      第44回日本創傷治癒学会
    • Place of Presentation
      ホテルメトロポリタン仙台(仙台市青葉区)
    • Year and Date
      2014-12-02 – 2014-12-03
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 活性イオウ分子種によるレドックスシグナルと酸化ストレス制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      第386回東北医学会例会シンポジウム
    • Place of Presentation
      東北大学艮陵会館記念ホール(仙台市青葉区)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスを制御する2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、末松 誠、本橋ほづみ、藤井重元、松永哲郎、山本や雅之、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] ポリサルファ化とタンパク質レドックス制御2014

    • Author(s)
      赤池孝章.
    • Organizer
      レドックスシンポジウム:酸素生物学の誕生
    • Place of Presentation
      名古屋大学ES総合館ESホール(名古屋市千種区)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 活性イオウ分子種による酸化ストレス制御とポリサルファーバイオロジー2014

    • Author(s)
      赤池孝章.
    • Organizer
      フォーラム2014 衛生薬学・環境トキシコロジー
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      2014-09-19 – 2014-09-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 活性システインパーサルファイドによる酸化ストレス制御2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、藤井重元、松永哲郎、Jon M Fukuto、赤池孝章.
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      同志社大学今出川キャンパス良心館(京都市上京区)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 8-ニトロ-cGMPを介した感染防御機構と細菌が産生する硫化水素による抑制2014

    • Author(s)
      松永哲郎、赤司壮一郎、ジョン ミンキョン、伊藤千秋、井田智章、藤井重元、澤 智裕、有本博一、赤池孝章.
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      同志社大学今出川キャンパス良心館(京都市上京区)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 活性イオウ分子種システインパースルフィドによる酸化ストレス制御2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、渡邊泰男、熊谷嘉人、本橋ほづみ、藤井重元、松永哲郎、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第8回レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎市)
    • Year and Date
      2014-08-21 – 2014-08-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 細菌の新しいシグナル伝達物質:8-ニトロ-cGMPの同定と機能解析2014

    • Author(s)
      井田智章、松永哲郎、赤司壮一郎、ジョン ミンギョン、津々木博康、藤井重元、居原 秀、澤 智裕、赤池孝章.
    • Organizer
      第25回日本生体防御学会学術総会
    • Place of Presentation
      東北大学 片平さくらホール(仙台市青葉区)
    • Year and Date
      2014-07-09 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 新興感染症菌Helicobacter cinaedi感染による動脈硬化の促進作用2014

    • Author(s)
      松永哲郎、岡本竜哉、藤井重元、井田智章、澤 智裕、河村好章、赤池孝章.
    • Organizer
      第25回日本生体防御学会学術総会
    • Place of Presentation
      東北大学 片平さくらホール(仙台市青葉区)
    • Year and Date
      2014-07-09 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] タンパク質過イオウ化:酸化ストレスの新しい制御システム2014

    • Author(s)
      赤池孝章.
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      神戸コンベンションセンター(神戸市中央区)
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Helicobacter cinaedi感染による動脈硬化促進作用.2014

    • Author(s)
      松永哲郎、赤池孝章.
    • Organizer
      第20回日本ヘリコバクター学会学術集会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2014-06-28 – 2014-06-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 8-ニトロ-cGMPによるオートファジーの誘導機構と細菌感染防御における役割2014

    • Author(s)
      伊藤千秋、松永哲郎、藤井重元、野澤孝志、齋藤洋平、井田智章、澤 智裕、中川一路、有本博一、赤池孝章.
    • Organizer
      第46回レンサ球菌研究会
    • Place of Presentation
      東京大学農学部弥生キャンパス内フードサイエンス棟中島董一郎記念ホール(東京都文京区)
    • Year and Date
      2014-06-27 – 2014-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Redox signal regulation by 8-nitro-cGMP and its metabolism involving reactive cysteine persulfide2014

    • Author(s)
      Takaaki Akaike.
    • Organizer
      8th International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      Renaissance Cleveland Hotel (Cleveland, OH, USA)
    • Year and Date
      2014-06-17 – 2014-06-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Metabolism of 8-nitro-cGMP and regulation of electrophilic signaling by reactive sulfur species2014

    • Author(s)
      Tomoaki Ida, Tomohiro Sawa, Hideshi Ihara, Yukihiro Tsuchiya, Yasuo Watanabe, Yoshito Kumagai, Hozumi Motohashi, Shigemoto Fujii, Tetsuro Matsunaga, Masayuki Yamamoto, Katsuhiko Ono, Jon M Fukuto, Takaaki Akaike.
    • Organizer
      8th International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide
    • Place of Presentation
      Renaissance Cleveland Hotel (Cleveland, OH, USA)
    • Year and Date
      2014-06-17 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 活性システインパーサルファイドとS-ポリチオレーションが酸化ストレスとレドックスシグナルを制御する2014

    • Author(s)
      井田智章、澤 智裕、居原 秀、土屋幸弘、熊谷嘉人、本橋ほづみ、藤井重元、松永哲郎、Ming Xian、Jon M Fukuto、赤池孝章.
    • Organizer
      第14回日本NO学会学術集会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀市)
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 8-ニトロ-cGMPによる感染防御機構と細菌由来硫化水素による抑制2014

    • Author(s)
      松永哲郎、赤司壮一郎、Jung Minkyung、伊藤千秋、井田智章、藤井重元、澤 智裕、有本博一、赤池孝章.
    • Organizer
      第14回日本NO学会学術集会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀市)
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Book] 別冊・医学のあゆみ「レドックスUPDATE ― ストレス制御の臨床医学・健康科学」(淀井淳司、平家俊男 監修/生田孝一、杉田昌彦、塚原孝一、豊國伸哉、前田裕弘 編)2015

    • Author(s)
      赤池孝章、藤井重元.
    • Total Pages
      341
    • Publisher
      医歯薬出版社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科環境保健医学分野 教室ホームページ

    • URL

      http://www.toxicosci.med.tohoku.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科 環境保健医学分野ホームページ

    • URL

      http://www.toxicosci.med.tohoku.ac.jp/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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