| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Viral RNAs are recognized by nucleic acid sensors in the cytoplasm of host cells. However, it is still unclear whether or not the host cells sense RNA virus infection inside the nuclear membrane. Here we demonstrate that host cells harbor the sensing machinery of intranuclear viral ribonucleoproteins (RNPs) leading to antiviral responses. We found that RNPs of intranuclear replicating RNA viruses, Borna disease virus and influenza virus, are recognized by IFI16 in the nucleus. Knockdown of IFI16 enhanced the replication of these viruses in the nucleus. Our data may provide a novel host machinery to recognize intranuclear non-self RNAs in the nucleus.
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