Analysis on RNA virus sensing machinery in the cell nucleus
| Project/Area Number |
26670225
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Kyoto University |
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Principal Investigator |
Keizo Tomonaga 京都大学, ウイルス研究所, 教授 (10301920)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルス / 細胞核 / RNA / 自然免疫 |
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| Outline of Final Research Achievements |
Viral RNAs are recognized by nucleic acid sensors in the cytoplasm of host cells. However, it is still unclear whether or not the host cells sense RNA virus infection inside the nuclear membrane. Here we demonstrate that host cells harbor the sensing machinery of intranuclear viral ribonucleoproteins (RNPs) leading to antiviral responses. We found that RNPs of intranuclear replicating RNA viruses, Borna disease virus and influenza virus, are recognized by IFI16 in the nucleus. Knockdown of IFI16 enhanced the replication of these viruses in the nucleus. Our data may provide a novel host machinery to recognize intranuclear non-self RNAs in the nucleus.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication.2015
Author(s)
Nakamura S, Horie M, Daidoji T, Honda T, Yasugi M, Kuno A, Komori T, Okuzaki D, Narimatsu H, Nakaya T, Tomonaga K.
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Journal Title
J Virol.
Volume: 90
Issue: 4
Pages: 1788-801
DOI
Related Report
Peer Reviewed / Open Access
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