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Adaptive immune system and intestinal flora in jawless vertebrates

Research Project

Project/Area Number 26670233
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionThe University of Tokyo

Principal Investigator

Nagawa Fumikiyo  東京大学, 理学(系)研究科(研究院), 講師 (10241233)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Yoshimasa  国立感染症研究所, 免疫部, 室長 (60311403)
Oshima Kenshiro  東京大学, 新領域創成科学研究科, 准教授 (40537411)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords無顎類 / 獲得免疫系 / 腸内細菌叢 / 抗原受容体 / VLR / 進化 / 遺伝子再編成
Outline of Final Research Achievements

Intestinal bacterial flora plays an important role in the adaptive immune system.The jawless vertebrates (lampreys and hagfish),the most phylogenetically distant vertebrates from mammals, possess an alternative form of adaptive immune system that is mediated by antigen receptors called VLRs (VLRA, VLRB and VLRC). To understand the relationship between intestinal flora and the adaptive immune system in jawless vertebrates, we tried to analyze VLR gene diversities in lamprey grown aseptically upto the stage 30, however, no mature VLR gene could be detected.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Presentation (5 results) (of which Invited: 1 results)

  • [Presentation] Antigen receptor gene assembly in hagfish2015

    • Author(s)
      Fumikiyo Nagawa
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Antigen receptor gene assembly in jawless vertebrates2015

    • Author(s)
      Fumikiyo Nagawa
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Antigen receptor gene assembly in hagfish2014

    • Author(s)
      Nagawa, F.
    • Organizer
      日本免疫学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Antigen receptor gene assembly in hagfish2014

    • Author(s)
      Nagawa, F.
    • Organizer
      日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Antigen receptor gene assembly in hagfish2014

    • Author(s)
      Nagawa, F.
    • Organizer
      11th International Congress on the Biology of Fish
    • Place of Presentation
      Edinburgh, the United Kingdom
    • Year and Date
      2014-08-03 – 2014-08-07
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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