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Role of nucleic acids sensors-induced cell death in shaping adaptive immunity

Research Project

Project/Area Number 26670236
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionNara Institute of Science and Technology

Principal Investigator

Kawai Taro  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (50456935)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自然免疫 / シグナル伝達 / 細胞死 / アジュバント / ウイルス核酸 / 樹状細胞 / ウイルス / 獲得免疫 / サイトカイン / 炎症
Outline of Final Research Achievements

Pathogen infection triggers death of host cells, but its role in regulation of immune responses remains unclear. In this study, we examined whether cell death of murine dendritic cells is induced by stimulation with agonists for innate immune receptors, and found that treatment of dendritic cells with R837, an agonist for Toll-like receptor (TLR) 7, resulted in cell death among other TLR agonists tested. Furthermore, this cell death was independent on TLR7, suggesting that R837 induces cell death via unknown pathways. As R837 is known as an adjuvant for virus infection, these results suggest that endogenous molecules released by dying dendritic cells upon R837 stimulation play roles in shaping adaptive immunity to viruses.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] IPS-1 differentially induces TRAIL, BCL2, BIRC3 and PRKCE in type I interferons-dependent and -independent anticancer activity.2015

    • Author(s)
      Kumar S, Ingle H, Mishra S, Mahla RS, Kumar A, Kawai T, Akira S, Takaoka A, Raut AA, Kumar H.
    • Journal Title

      Cell Death Dis.

      Volume: 6 Issue: 5 Pages: e1758-e1758

    • DOI

      10.1038/cddis.2015.122

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TLR9 signaling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus2015

    • Author(s)
      Matsuda T., Murao N., Katano Y., Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 6514-6514

    • DOI

      10.1038/ncomms7514

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.2015

    • Author(s)
      Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, Akira S, Kawai T.
    • Journal Title

      J Biol Chem.

      Volume: 290 Issue: 2 Pages: 1269-80

    • DOI

      10.1074/jbc.m114.611053

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Toll-like receptor signaling pathways.2014

    • Author(s)
      Kawasaki T, Kawai T.
    • Journal Title

      Front Immunol.

      Volume: 5 Pages: 461-461

    • DOI

      10.3389/fimmu.2014.00461

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microbial sensing by toll-like receptors and intracellular nucleic acid sensors.2014

    • Author(s)
      Pandey S, Kawai T, Akira S.
    • Journal Title

      Cold Spring Harb Perspect Biol.

      Volume: 7 Issue: 1 Pages: a016246-a016246

    • DOI

      10.1101/cshperspect.a016246

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nucleic acid sensing by T cells initiates Th2 cell differentiation.2014

    • Author(s)
      Imanishi T, Ishihara C, Badr Mel S, Hashimoto-Tane A, Kimura Y, Kawai T, Takeuchi O, Ishii KJ, Taniguchi S, Noda T, Hirano H, Brombacher F, Barber GN, Akira S, Saito T
    • Journal Title

      Nat Commun

      Volume: 10 Issue: 1 Pages: 3566-3566

    • DOI

      10.1038/ncomms4566

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.2014

    • Author(s)
      Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 111 Issue: 15 Pages: 5646-5651

    • DOI

      10.1073/pnas.1401674111

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] ELMO domain-containing protein 2 (ELMOD2)による抗ウイルス自然免疫制御機構の解析2015

    • Author(s)
      村瀬 本弥、川崎 拓実、河合 太郎
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] ウイルスRNAに対する自然免疫応答におけるユビキチンリガーゼMex3cの役割2015

    • Author(s)
      河合 太郎、國吉 佳奈子、竹内 理、審良 静男
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Identification of HuR as a molecule that mediates antiviral innate immune responses2015

    • Author(s)
      Takuya Sueyoshi, Takumi Kawasaki, Taro Kawai
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of the lipid kinase PIKfyve in alveolar macrophage2015

    • Author(s)
      Takumi Kawasaki, Taro Kawai
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of HuR as a molecule that mediates antiviral innate immune responses2014

    • Author(s)
      Takuya Sueyoshi, Motoya Murase, Rikito Murata, Takumi Kawasaki, Taro Kawai
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Physiological role of the lipid kinase PIKfyve in innate immune responses2014

    • Author(s)
      Takumi Kawasaki, Rika Tanaka, Kousuke Ito, Shizuo Akira, Taro Kawai
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Negative regulation of Mda5-mediated antiviral response by Arl5B2014

    • Author(s)
      Yuishi Kitai. Daisuke Ori, Takuya Sueyoshi, Motoya Murase, Takumi Kawasaki, Taro Kawai
    • Organizer
      第43回日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Arl5B-mediated negative regulation of MDA5-dependent innate immune signaling2014

    • Author(s)
      鍛代悠一、織大祐、末吉拓也、村瀬本弥、川崎拓実、竹内理、審良静男、河合太郎
    • Organizer
      第13回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      奈良県新公会堂(奈良県奈良市)
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Arl5B negatively regulates Mda5-mediated innate immune signaling2014

    • Author(s)
      鍛代悠一、織大輔、末吉拓也、村瀬元弥、川崎拓実、竹内理、審良静男、河合太郎
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂(奈良県奈良市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 免疫応答におけるホスファチジルイノシトール5リン酸の役割2014

    • Author(s)
      川崎拓実、武村直紀、ダロンスタンドリー、審良静男、河合太郎
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂(奈良県奈良市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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