Trials for foundation of cadaver preservation

• Project/Area Number: 26670254
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical sociology
• Research Institution: Tokyo Medical University
• Principal Investigator: Kawata Shinichi 東京医科大学, 医学部, 助手 (00527955)
• Co-Investigator(Renkei-kenkyūsha): HATAYAMA Naoyuki 東京医科大学, 医学部, 助教 (80534792) ; QU Ning 東京医科大学, 医学部, 講師 (70527952) ; HAYASHI Shogo 東京医科大学, 医学部, 准教授 (60349496) ; ITOH Masahiro 東京医科大学, 医学部, 主任教授 (00232471)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: ホルムアルデヒド（FA） / 防腐 / 固定 / 低減 / ホルムアルデヒド（FA ） / SSS法 / 尿素法 / Thiel法 / プリザーブ法

Outline of Final Research Achievements

Formaldehyde (FA) is widely used as a fix solution of the cadavers for anatomical training. However it is known that FA causes health problems such as respiratory failure and mucous membrane disorders. Furthermore, it has been attracting attention as a carcinogen.
Rapporteurs have tried to develop various embalming solutions to the cadavers and studied their fixed and antiseptic effect. The FA concentration could be successfully reduced to less than 1.0 ppm before thoracotomy and laparotomy. However, FA concentration increased after thoracotomy and laparotomy. Further countermeasures are required against FA in the cadavers' splandnnic organs.

Research Products

• [Journal Article] History and future of human cadaver preservation for surgical training: from formalin to saturated salt solution method (2016)
  • Author(s): Shogo Hayashi, Munekazu Naito, Shinichi Kawata, Ning Qu, Naoyuki Hatayama, Shuichi Hirai, Masahiro Itoh
  • Journal Title: Anatomical Science International Volume: 91 Issue: 1 Pages: 1-7
  • DOI: 10.1007/s12565-015-0299-5
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Saturated salt solution method: a useful cadaver embalming for surgical skills training (2014)
  • Author(s): Hayashi S, Homma H, Naito M, Oda J, Nishiyama T, Kawamoto A, Kawata S, Sato N, Fukuhara T, Taguchi H, Mashiko K, Azuhata T, Ito M, Kawai K, Suzuki T, Nishizawa Y, Araki J, Matsuno N, Shirai T, Qu N, Hatayama N, Hirai S, Fukui H, Ohseto K, Yukioka T, Itoh M.
  • Journal Title: Medicine Volume: 93 Issue: 27 Pages: e196-e196
  • DOI: 10.1097/md.0000000000000196
  • Peer Reviewed / Open Access
• [Presentation] SSS法と尿素法による解剖体ホルムアルデヒド濃度低減効果 (2016)
  • Author(s): 河田晋一、小山耕一、林省吾、平井宗一、曲寧、畑山直之、 中村陽市、伊藤正裕
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま
  • Year and Date: 2016-03-28
• [Presentation] Saturated salt solution (SSS) 法を用いたサージカルトレーニング：形成外科学, 脳外科学領域への拡張 (2016)
  • Author(s): 林省吾、河田晋一、白井隆之、曲寧、畑山直之、平井宗一、伊藤正裕
  • Organizer: 第121回日本解剖学会総会・全国学術集会
  • Place of Presentation: ビッグパレットふくしま
  • Year and Date: 2016-03-28
• [Presentation] ２．Saturated salt solution法固定遺体のサージカル・トレーニングへの有用性：外科医の評価と手技施行の可能性 (2015)
  • Author(s): 林 省吾, 河田晋一, 曲 寧, 畑山直之, 内藤宗和, 平井宗一, 伊藤正裕
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] サージカルトレーニングから見た各種固定法の比較：防腐効果と硬化について (2015)
  • Author(s): 河田晋一, 小山耕一, 林 省吾, 曲 寧, 畑山直之, 中村陽市, 藤倉義久, 伊藤正裕
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸国際会議場・展示場
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] １．Cadavers embalmed by the saturated salt solution method are useful for surgical skills training (2014)
  • Author(s): Hayashi S, Naito M, Kawata S, Qu N, Hatayama N, Hirai S, Itoh M
  • Organizer: 第2回アジア臨床解剖学会/第18回臨床解剖研究会
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2014-11-08 – 2014-11-09