Exploration of diagnostic marker for nonalcoholic steatohepatitis by using unique NASH model mouse

• Project/Area Number: 26670273
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: University of Tsukuba
• Principal Investigator: Onizawa Kojiro 筑波大学, 医学医療系, 教授 (60194578)
• Co-Investigator(Kenkyū-buntansha): WARABI Eiji 筑波大学, 医学医療系, 講師 (70396612)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 非アルコール性脂肪性肝炎 / NASH

Outline of Final Research Achievements

Nonalcoholic steatohepatitis (NASH) is poor prognosis disease with inflammation and fibrosis in liver as well as steatosis without apparent drinking history. The aim of this study was to explore novel noninvasive diagnostic marker for NASH by using unique NASH model mouse. We found 6 proteins including apolipoprotein A-V are valuable novel candidates for diagnosis of NASH.