| Project/Area Number |
26670301
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 和正 九州大学, 大学病院, 准教授 (20284507)
藤淵 俊王 九州大学, 医学研究院, 准教授 (20375843)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 子宮頸がん / 腔内照射 / 患者体内情報の可視化 / モンテカルロシミュレーション / brachytherapy / portable camera / seed locations / uterine cervical cancer / Monte Carlo simulation / tissue heterogeneity / computed tomography / cervical cancer / Monte Carlo simulations / tissue inhomogeneity / image-guided BT |
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| Outline of Final Research Achievements |
The purpose of this study was to research a novel approach for real-time visualization of four-dimensional dose distributions on morphological images for intracavitary brachytherapy using a mobile gamma camera (MGC). We designed a geometry of ICBT of cervical cancer using a Monte Carlo simulation, and calculated two dose distributions in a clinical computed tomography image and water phantom. As the results, we found that there were discrepancies between two distributions around the applicator for four treatment fractions. In addition, we developed a novel approach for visualization of in-vivo information on locations of an 192Ir source using the MGC. Further, our results suggested that he three-dimensional adaptive plans are expected to be robust against interfractional location variations in each treatment fraction.
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