Effect of proteins in PM2.5 on PM2.5-induced airway inflammation.
| Project/Area Number |
26670331
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Okayama University |
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Principal Investigator |
OGINO KEIKI 岡山大学, 医歯(薬)学総合研究科, 教授 (70204104)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEMOTO KEI 岡山大学, 医歯薬学総合研究科, 助教 (60723252)
KUBO MASAYUKI 岡山大学, 医歯薬学総合研究科, 助教 (60420519)
NAGAOKA KENJIRO 岡山大学, 医歯薬学総合研究科, 助教 (40752374)
OBASE YASUSHI 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (40399762)
NAKAYAMA SHOJI 独立行政法人国立環境研究所, 環境健康研究センター 総合影響評価研究室, 室長 (00368705)
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| Co-Investigator(Renkei-kenkyūsha) |
ENOMOTO SHUICHI 岡山大学, 医歯薬学総合研究科, 教授 (10271553)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | PM2.5 / PM2.5蛋白 / 喘息 / 蛋白質 / PM蛋白１ / PM蛋白２ |
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| Outline of Final Research Achievements |
The aim of research is to clear the contribution of protein in the mechanism of PM2.5-induced asthma in mice. In particle size of PM2.5 from 2.5 micro m to 0.1 micro m, there was no protein to evoke asthma. PM2.5, particular size below 0.1 micro m, may contain some protein to evoke asthma. PM2.5, eluted from filter of Anderson-type high volume air sampler, induced asthma and generated specific antibody against PM2.5 proteins. After elution of PM2.5 specific proteins by antibody sedimentation technique, two human origin proteins were determined. We decided the name of proteins, PM protein 1 and PM protein 2. Pure PM protein 1 could evoke asthma when PM protein 1 was administered with PM2.5, and pure PM protein 2 alone could evoke asthma. Significant high antibody titers against tyrosine nitrated-PM protein 1were demonstrated in the serum of asthmatic patients compared to healthy control.
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Report
(3 results)
Research Products
(12 results)
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[Presentation] PM2.5とタンパク質2015
Author(s)
荻野景規, 長岡憲次郎, 久保正幸, 岡瑛良, 江口依里, 尾長谷靖, 藏満保宏
Organizer
第25回日本産業衛生学会 産業医・産業看護全国協議会 合同開催 第24回産業衛生技 術部会大会
Place of Presentation
周南市周南市文化会館
Year and Date
2015-09-18
Related Report
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[Presentation] PM2.5のタンパク質を介した生体影響2015
Author(s)
荻野景規, 長岡憲次郎, 久保正幸, 岡瑛良, 江口依里, 藏光保宏
Organizer
第13回日本予防医学会学術総会
Place of Presentation
金沢市フレンドパーク石川(石川県勤労者福祉文化会館)
Year and Date
2015-06-21
Related Report
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