Involvement of apoptosis inhibitory factor of macrophage (AIM) on pathophysiological condition of chronic liver disease

• Project/Area Number: 26670385
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kagoshima University
• Principal Investigator: TSUBOUCHI Hirohito 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (60145480)
• Co-Investigator(Kenkyū-buntansha): UTO Hirofumi 鹿児島大学, 大学院医歯学総合研究科, 准教授 (20347058)
• Co-Investigator(Renkei-kenkyūsha): IBUSUKI Rie 鹿児島大学, 大学院医歯学総合研究科, 助教 (90747015)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: アポトーシス抑制因子 / AIM / C型慢性肝炎 / 非アルコール性脂肪性肝疾患 / 肝線維化 / アポトーシス / C型肝炎 / 脂肪肝 / 非アルコール性脂肪肝炎

Outline of Final Research Achievements

Apoptosis inhibitor of macrophage (AIM) is a protein that is specifically produced and secreted from macrophages, and is involved in metabolic syndrome and insulin resistance. However, the association between AIM and chronic liver disease is unclear. In this study, we found that the serum AIM concentration is correlated with liver fibrosis in chronic hepatitis C and nonalcoholic fatty liver disease (NAFLD). In addition, we showed that AIM and adipocytokines are associated with the pathogenesis of chronic hepatitis C and NAFLD through different mechanisms. Furthermore, liver fibrosis induced by a choline-deficient amino acid-defined diet was promoted in mice expressing macrophage-specific AIM. These results show that AIM is both a candidate marker and a stimulatory factor for liver fibrosis in chronic liver disease.

Research Products

• [Journal Article] Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis (2015)
  • Author(s): Yoshimine Y, Uto H, Kumagai K, Mawatari S, Arima S, Ibusuki R, Mera K, Nosaki T, Kanmura S, Numata M, Tamai T, Moriuchi A, Tsubouchi H, Ido A
  • Journal Title: Oncol Rep Volume: 33 Issue: 4 Pages: 1657-66
  • DOI: 10.3892/or.2015.3745
  • Peer Reviewed
• [Presentation] Serum levels of apoptosis inhibitor of macrophage (AIM) are associated with hepatic fibrosis and insulin resistance in patients with nonalcoholic fatty liver disease (2014)
  • Author(s): Kohei Oda, Hirofumi Uto, Yoshio Sumida, Takeshi Okanoue, Seiichi Mawatari, Hiroka Onishi, Haruka Sakae, Kaori Muromachi, Eriko Tabu, Akihiko Oshige, Dai Imanaka, Tsutomu Tamai, Akihiro Moriuchi, Hirohito Tsubouchi, Akio Ido
  • Organizer: THE LIVER MEETING 2014 - AASLD, 65th Annual Meeting of the American Association for the Study of Liver Diseases
  • Place of Presentation: Boston, MA, USA（John B. Hynes Veterans Memorial Convention Center）
  • Year and Date: 2014-11-07 – 2014-11-11
• [Presentation] アポトーシス抑制因子AIMは非アルコール性脂肪性肝疾患の病態進展に関与する (2014)
  • Author(s): 小田耕平、宇都浩文、岡上武
  • Organizer: 第18回 日本肝臓学会大会
  • Place of Presentation: 神戸（ポートピアホテル）
  • Year and Date: 2014-10-23 – 2014-10-24
• [Presentation] 非アルコール性脂肪性肝疾患におけるApoptosis Inhibitor of Macrophage（AIM）の臨床的意義 (2014)
  • Author(s): 小田耕平、宇都浩文、角田圭雄、馬渡誠一、大西容雅、坂江遥、室町香織、椨 恵理子、大重彰彦、玉井努、森内昭博、岡上武、坪内博仁、井戸章雄
  • Organizer: 第51回 日本消化器免疫学会総会
  • Place of Presentation: 京都（京都大学医学部 芝蘭会館）
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] アポトーシス抑制因子AIMは非アルコール性脂肪性肝疾患の病態と関連する (2014)
  • Author(s): 小田耕平、宇都浩文、角田圭雄、馬渡誠一、椨一晃、椨恵理子、室町香織、大重彰彦、熊谷公太郎、玉井努、森内昭博、桶谷眞、坪内博仁、井戸章雄
  • Organizer: 第103回 日本消化器病学会九州支部例会
  • Place of Presentation: 福岡（アクロス福岡）
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] 非アルコール性脂肪性肝疾患の病態におけるApoptosis Inhibitor of Macrophageの意義 (2014)
  • Author(s): 小田耕平、宇都浩文、馬渡誠一、指宿りえ、椨一晃、大野香織、椨恵理子、大重彰彦、今中大、熊谷公太郎、玉井努、森内昭博、桶谷真、井戸章雄、角田圭雄、岡上武、坪内博仁
  • Organizer: 第50回 日本肝臓学会総会
  • Place of Presentation: 東京（ホテルニューオータニ）
  • Year and Date: 2014-05-29 – 2015-05-30