Involvement of apoptosis inhibitory factor of macrophage (AIM) on pathophysiological condition of chronic liver disease
Project/Area Number |
26670385
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Kagoshima University |
Principal Investigator |
TSUBOUCHI Hirohito 鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (60145480)
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Co-Investigator(Kenkyū-buntansha) |
UTO Hirofumi 鹿児島大学, 大学院医歯学総合研究科, 准教授 (20347058)
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Co-Investigator(Renkei-kenkyūsha) |
IBUSUKI Rie 鹿児島大学, 大学院医歯学総合研究科, 助教 (90747015)
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Project Period (FY) |
2014-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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Keywords | アポトーシス抑制因子 / AIM / C型慢性肝炎 / 非アルコール性脂肪性肝疾患 / 肝線維化 / アポトーシス / C型肝炎 / 脂肪肝 / 非アルコール性脂肪肝炎 |
Outline of Final Research Achievements |
Apoptosis inhibitor of macrophage (AIM) is a protein that is specifically produced and secreted from macrophages, and is involved in metabolic syndrome and insulin resistance. However, the association between AIM and chronic liver disease is unclear. In this study, we found that the serum AIM concentration is correlated with liver fibrosis in chronic hepatitis C and nonalcoholic fatty liver disease (NAFLD). In addition, we showed that AIM and adipocytokines are associated with the pathogenesis of chronic hepatitis C and NAFLD through different mechanisms. Furthermore, liver fibrosis induced by a choline-deficient amino acid-defined diet was promoted in mice expressing macrophage-specific AIM. These results show that AIM is both a candidate marker and a stimulatory factor for liver fibrosis in chronic liver disease.
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Report
(2 results)
Research Products
(6 results)
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[Journal Article] Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis2015
Author(s)
Yoshimine Y, Uto H, Kumagai K, Mawatari S, Arima S, Ibusuki R, Mera K, Nosaki T, Kanmura S, Numata M, Tamai T, Moriuchi A, Tsubouchi H, Ido A
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Journal Title
Oncol Rep
Volume: 33
Pages: 1657-66
DOI
Related Report
Peer Reviewed
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[Presentation] Serum levels of apoptosis inhibitor of macrophage (AIM) are associated with hepatic fibrosis and insulin resistance in patients with nonalcoholic fatty liver disease2014
Author(s)
Kohei Oda, Hirofumi Uto, Yoshio Sumida, Takeshi Okanoue, Seiichi Mawatari, Hiroka Onishi, Haruka Sakae, Kaori Muromachi, Eriko Tabu, Akihiko Oshige, Dai Imanaka, Tsutomu Tamai, Akihiro Moriuchi, Hirohito Tsubouchi, Akio Ido
Organizer
THE LIVER MEETING 2014 - AASLD, 65th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Presentation
Boston, MA, USA(John B. Hynes Veterans Memorial Convention Center)
Year and Date
2014-11-07 – 2014-11-11
Related Report
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