Identification and purification of cardiac fibroblast-specific FGF23 receptor

• Project/Area Number: 26670412
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KITAKAZE Masafumi 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 部長 (20294069)
• Co-Investigator(Kenkyū-buntansha): 朝倉 正紀 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (80443505) ; 瀬口 理 国立研究開発法人国立循環器病研究センター, 病院, 医師 (60570869) ; 中野 敦 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (90648106)
• Research Collaborator: ITO Shin ; IMAZU Miki ; TAKASHIMA Seiji ; MIN Kyung-Duk ; SHINDO Kazuhiro ; YAMAZAKI Satoru ; FUKUDA Hiroki
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 循環器・高血圧 / トランスレーショナルリサーチ

Outline of Final Research Achievements

We have reported that serum concentration of fibroblast growth factor 23 (FGF23) is significantly increased in patients with heart failure, and FGF23 level is associated with the extent of cardiac fibrosis. These findings led us to investigate the association between FGF23 and cardiac fibrosis. In this study, we found that FGF23 leads to transdifferentiate from fibroblast into myofibroblast, and then increases collagen gene expression using human cardiac fibroblast. We also identified FGF23 receptor in cardiac fibroblast. These results suggest that FGF23 may be a novel therapeutic target for heart failure.

Research Products

• [Journal Article] Pathophysiological impact of serum fibroblast growth factor 23 in patients with nonischemic cardiac disease and early chronic kidney disease. (2014)
  • Author(s): Imazu M, Takahama H, Asanuma H, Funada A, Sugano Y, Ohara T, Hasegawa T, Asakura M, Kanzaki H, Anzai T, Kitakaze M.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 307(10) Issue: 10 Pages: H1504-H1511
  • DOI: 10.1152/ajpheart.00331.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Effects of the oral adsorbent of AST-120 in patients with both chronic heart failure and chronic kidney disease. (2014)
  • Author(s): Imazu M, Asakura M, Hasegawa T, Asanuma H, Ito S, Nakano A, Funada A, Sugano Y, Ohara T, Kanzaki H, Takahama H, Morita T, Anzai T, Kitakaze M
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19