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Identification and purification of cardiac fibroblast-specific FGF23 receptor

Research Project

Project/Area Number 26670412
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

KITAKAZE Masafumi  国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 部長 (20294069)

Co-Investigator(Kenkyū-buntansha) 朝倉 正紀  国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (80443505)
瀬口 理  国立研究開発法人国立循環器病研究センター, 病院, 医師 (60570869)
中野 敦  国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (90648106)
Research Collaborator ITO Shin  
IMAZU Miki  
TAKASHIMA Seiji  
MIN Kyung-Duk  
SHINDO Kazuhiro  
YAMAZAKI Satoru  
FUKUDA Hiroki  
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords循環器・高血圧 / トランスレーショナルリサーチ
Outline of Final Research Achievements

We have reported that serum concentration of fibroblast growth factor 23 (FGF23) is significantly increased in patients with heart failure, and FGF23 level is associated with the extent of cardiac fibrosis. These findings led us to investigate the association between FGF23 and cardiac fibrosis. In this study, we found that FGF23 leads to transdifferentiate from fibroblast into myofibroblast, and then increases collagen gene expression using human cardiac fibroblast. We also identified FGF23 receptor in cardiac fibroblast. These results suggest that FGF23 may be a novel therapeutic target for heart failure.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Pathophysiological impact of serum fibroblast growth factor 23 in patients with nonischemic cardiac disease and early chronic kidney disease.2014

    • Author(s)
      Imazu M, Takahama H, Asanuma H, Funada A, Sugano Y, Ohara T, Hasegawa T, Asakura M, Kanzaki H, Anzai T, Kitakaze M.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 307(10) Issue: 10 Pages: H1504-H1511

    • DOI

      10.1152/ajpheart.00331.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Effects of the oral adsorbent of AST-120 in patients with both chronic heart failure and chronic kidney disease.2014

    • Author(s)
      Imazu M, Asakura M, Hasegawa T, Asanuma H, Ito S, Nakano A, Funada A, Sugano Y, Ohara T, Kanzaki H, Takahama H, Morita T, Anzai T, Kitakaze M
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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