Development of complement component MASP-1/3 inhibitors for treatment of lupus animal models.
Project/Area Number |
26670478
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
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Research Institution | Fukushima Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MACHIDA TAKESHI 福島県立医科大学, 医学部, 助教 (80583632)
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Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI MINORU 福島県立医科大学, 医学部, 准教授 (00285024)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 補体 / レクチン経路 / 第二経路 / MASP-1/3 / MAp44 |
Outline of Final Research Achievements |
We generated two recombinant proteins(MAp44-Ig, MAp44-fH)to threat diseases that are associated with activation of the complement lectin and alternative pathways such as lupus. In vitro experiments using mannan-coated microplates showed that MAp44-fH has stronger effect on the lectin and alternative pathway inhibition compared to MAp44-Ig. In vivo experiments by using sera from mice that received peritoneal administration of MAp44-fH showed inhibitory effect of the lectin and alternative pathways. MAp44-fH will be administrated to murine lupus models afterwards.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Granular C3 Dermatosis.2016
Author(s)
Hashimoto T, Tsuruta D, Yasukochi A, Imanishi H, Sekine H, Fujita T, Wanibuchi H, Gi M, Kárpáti S, Sitaru C, Zone JJ, Endo D, Abe S, Nishino T, Koji T, Ishii N.
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Journal Title
Acta Derm Venereol
Volume: 00
Pages: 00-00
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Upregulation of Complement C3 and Alpha-2-Macroglobulin in Cerebrospinal Fluid of Neuropsychiatric Systemic Lupus Erythematosus2015
Author(s)
Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Yoshinobu Kariya, Hiromi Ito, Kyoka Hoshi, Akioh Yoshihara, Yoshikazu Ugawa, Minoru Takahashi, Hideharu Sekine, Shunsei Hirohata, Hiroshi Watanabe, Hiromasa Ohira and Yasuhiro Hashimoto
Organizer
2015-Annual Scientific Meeting of the American College of Rheumatology
Place of Presentation
San Francisco, CA, USA
Year and Date
2015-11-08
Related Report
Int'l Joint Research
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