Comprehensive Analysis of the Regulation of Basophil Development
| Project/Area Number |
26670502
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIKAWA Yumiko 徳島大学, 疾患プロテオゲノム研究センター, 助教 (60448214)
WADA Takeshi 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 (80583418)
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| Research Collaborator |
MINEGISHI Shizuko
INOUE Fumiko
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | アレルギー |
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| Outline of Final Research Achievements |
Hyper-IgE syndrome is one of the primary immunodeficiency, caused by dominant negative mutations of the STAT3 gene (Minegishi et al. Nature 2007). Most of the patients with this disorder suffer from severe atopic dermatitis, but the mechanistic basis is still elusive. To elucidate a molecular mechanism, we established a model mice of this syndrome and developed an atopic dermatitis model with the mice. We found that atopic dermatitis is more severe in Stat3 dominant negative mice compared to wild-type mice. We investigate the molecular mechanism of this phenotype.
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Report
(2 results)
Research Products
(8 results)
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[Journal Article] Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program2014
Author(s)
Nishikawa, Y., Nishijima, H., Matsumoto, M., Morimoto, J., Hirota, F., Takahashi, S., Luche, H., Fehling, H.J., Mouri, Y., Matsumoto, M.
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Journal Title
J. Immunol
Volume: 192
Issue: 6
Pages: 2585-2592
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis.2014
Author(s)
Mizoguchi Y, Tsumura M, Okada S, Hirata O, Minegishi S, Imai K, Hyakuna N, Muramatsu H, Kojima S, Ozaki Y, Imai T, Takeda S, Okazaki T, Ito T, Yasunaga S, Takihara Y, Bryant VL, Kong XF, Cypowyj S, Boisson-Dupuis S, Puel A, Casanova JL, Morio T, Kobayashi M.
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Journal Title
J. Leukoc. Biol.
Volume: 95
Issue: 4
Pages: 667-76
DOI
Related Report
Peer Reviewed / Open Access
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