Development of in vivo imaging of protective and detrimental microglial activities for treating mental disorders
| Project/Area Number |
26670538
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Yasuomi Ouchi 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978)
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| Co-Investigator(Kenkyū-buntansha) |
植木 孝俊 名古屋市立大学, 大学院医学研究科, 教授 (60317328)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ミクログリア活性 / 精神神経疾患 |
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| Outline of Final Research Achievements |
The previous in vivo studies on microglial activity mainly described the features of inflammatory microglial activation, which did not allow detection of which was contributory to neuroinflammation in diseases, protective or inflammatory microglia. So, a new method that could monitor microglial activation using imaging technique was longed for to elucidate the contribution of microglial activation in diseases.
We tried to develop a new monitoring system by MRI and PET about dynamic aspects of microglial activation, namely, development of a MR probe that depended on the amount of fractalkine produced and a PET CB2R ligand imaging for activated microglia. Although an MR probe was not satisfactory, the CB2R probe was able to depict some level of microglial activation. However, a more sensitive probe was expected for illustration of two types of activated microglia.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Florbetaben Phase 3 Study Group. Florbetaben PET imaging to detect amyloid plaques in Alzheimer disease2015
Author(s)
Sabri O, Sabbagh MN, Seibyl J, Barthel H, Akatsu H, Ouchi Y, Senda K, Murayama S, Ishii K, Takao M, Beach TG, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Catafau AM, Stephens AW, Mueller A, Koglin N, Hoffmann A, Roth K, Reininger C, Schulz-Schaeffer WJ
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Journal Title
Alzheimers Dement
Volume: 11
Issue: 8
Pages: 964-974
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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