| Project/Area Number |
26670553
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Magata Yasuhiro 浜松医科大学, 光尖端医学教育研究センター, 教授 (20209399)
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| Co-Investigator(Kenkyū-buntansha) |
阪原 晴海 浜松医科大学, 医学部, 教授 (10187031)
鈴木 千恵 浜松医科大学, 光尖端医学教育研究センター, 助教 (20637285)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | PET / がん / C-11 / 金属錯体 / マウス / 放射性医薬品 / イメージングプローブ / 生体内金属 / 銅 / 放射線 |
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| Outline of Final Research Achievements |
There are many metal related biochemical reactions in the living cells. To image these reactions in vivo without radio-metal nuclide is expected to be useful for pathological elucidation of trace metal related diseases. In this study, we aim to develop a novel PET organic imaging probe for these reactions. Cu-ATSM was selected for a model compound of our POC. C-11-Cu-ATSM-D1 was obtained by C-11 methylation of Cu-ATSM-D2 by optimization of several reaction parameters. Accumulation of radioactivity post injection of C-11-ATSM-D1 in the tumor was observed in vivo and the distribution of the radioactivity in the tumor was heterogeneous. POC can be obtained with more studies.
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