application of high resolution arufa-autoradiography for analysing micro-distribution of B-compund in tissues and its BNCT effects

• Project/Area Number: 26670557
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: ONO Koji 京都大学, 原子炉実験所, 寄附研究部門教員 (90122407)
• Co-Investigator(Kenkyū-buntansha): 田中 浩基 京都大学, 原子炉実験所, 准教授 (70391274)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: BNCT / CBEファクター / BPA / BSH / 放射線脳壊死 / 放射線肺線維症 / 正常組織反応 / BNCT脳壊死 / BNCT肺線維症 / 硼素中性子捕捉療法 / 晩期有害事象 / CBE値 / 脳壊死 / 肺線維症 / ホウ素中性子捕捉療法 / 晩期障害

Outline of Final Research Achievements

A new formula to describe the relation between CBE factor and B-10 level in tissue. For brain radio-necrosis, CBE=0.32+N/Bx1.65. N and B are B-10 level (ppm) in the normal brain and the blood. For BSH, it is independent of B-10 level in the tissue and a fixed value (=0.36). For lung fibrosis, CBE=0.32+N/Bx1.80. For BSH, there exsist no data for analysis.
it is independent of B-10 level in the tissue and a fixed value (=0.36).
As above analysis, B-10 level in normal brain is very important factor. An idea to selectively reduce the B-10 level was discovered when BPA was applied to BNCT. Predosing of PA (phenylalanine) prior to BPA administration markedly decreased B-10 level of brain tissue and an increase of therapetuic gain factor is expected in clinical BPA-BNCT for brain tumor.

Research Products

• [Journal Article] An analysis of the structure of the compound biological effectiveness factor (2016)
  • Author(s): Koji Ono
  • Journal Title: Journal of Radiation Research Volume: 57(S1) Issue: S1 Pages: i83-i89
  • DOI: 10.1093/jrr/rrw022
  • NAID: 120006223641
  • Peer Reviewed / Open Access
• [Journal Article] L-phenylalanine preloading reduces the 10B(n,)7Li dose to the normal brain by inhibiting the uptake of boronophenylalanine in boron neutron capture therapy for brain tumours. (2016)
  • Author(s): Tsubasa Watanabe, Hiroki Tanaka, Satoshi Fukutani, Minoru Suzuki,Masahiro Hiraoka, Koji Ono
  • Journal Title: Cancer Letterｓ Volume: 370 Issue: 1 Pages: 27-32
  • DOI: 10.1016/j.canlet.2015.10.004
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis (2014)
  • Author(s): Masunaga SI, Sakurai Y, Tano K, Tanaka H, Suzuki M, Kondo N, Narabayashi M, Watanabe T, Nakagawa Y, Maruhashi A, Ono K.
  • Journal Title: Exp Ther Med. Volume: 8 Pages: 291-301
  • NAID: 120005646497
  • Peer Reviewed / Open Access
• [Journal Article] A case of radiation-induced osteosarcoma treated effectively by boron neutron capture therapy. (2014)
  • Author(s): Gen Futamura, Shinji Kawabata, Hiroyuki Siba, Toshihiko Kuroiwa, Minoru Suzuki, Natsuko Kondo, Yoshinori Sakurai, Koji Ono, Minoru Tanaka, Tomoki Todo and Shin-Ichi Miyatake
  • Journal Title: Radiat Oncol. Volume: 4;9(1) Issue: 1 Pages: 237-237
  • DOI: 10.1186/s13014-014-0237-z
  • Peer Reviewed / Open Access