Development of MR molecular imaging for brain amyloid detection: PET/MRI approach

• Project/Area Number: 26670564
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kagoshima University
• Principal Investigator: YOSHIURA Takashi 鹿児島大学, 医歯学域医学系, 教授 (40322747)
• Co-Investigator(Kenkyū-buntansha): HIWATASHI Akio 九州大学, 大学病院, 助教 (30444855) ; TOGAO Osamu 九州大学, 大学病院, 助教 (10452749) ; YAMASHITA Koji 九州大学, 大学病院, 助教 (80546565) ; BABA Shingo 九州大学, 大学病院, 講師 (80380450) ; ISODA Takuro 札幌医科大学, 医学部, 助教 (90452747) ; OHYAGI Yasumasa 愛媛大学, 医学系研究科, 教授 (30301336) ; KUMAZAWA Seiji 北海道科学大学, 保健医療学部, 教授 (50363354) ; HONDA Hiroshi 九州大学, 医学研究院, 教授 (90145433)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: アルツハイマー病 / アミロイド / MRI / PET / ＭＲＩ / ＰＥＴ

Outline of Final Research Achievements

We performed an in-vitro phantom experiment and revealed that beta-amyloid can be detected by means of chemical exchange saturation transfer (CEST) imaging. We evaluated the effect of skull in PET/MRI measurement of PIB accumulation. As a results, we found that presence of skull led to significant underestimate of SUV in the cortex and the cerebellum, in comparison with those by PET/CT. This finding suggested a need for customized standard of SUV and SUVr for PET/MRI detection of amyloid. We developed a more objective and reproducible method for amyloid detection in PIB-PET/MRI takin advantage of MRI morphological information.

Research Products

• [Journal Article] Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors (2015)
  • Author(s): Togao O, Hiwatashi A, Keupp J, Yamashita K, Kikuchi K, Yoshiura T, Suzuki Y, Kruiskamp MJ, SagiyamaK, Takahashi M, Honda H
  • Journal Title: J Magn Reson Imaging Volume: 未定 Issue: 5 Pages: 1346-1353
  • DOI: 10.1002/jmri.24895
  • Peer Reviewed
• [Journal Article] The effect of the saturation pulse duration on chemical exchange saturation transfer in amide proton transfer MR imaging: a phantom study (2015)
  • Author(s): Wada T, Togao O, Tokunaga C, Funatsu R, Kobayashi K. Nakamura Y
  • Journal Title: Radiol Phys Technol Volume: 未定
  • Peer Reviewed
• [Journal Article] Amide Proton Transfer（APT）イメージング (2014)
  • Author(s): 栂尾理，樋渡昭雄，山下孝二，菊地一史，本田浩，吉浦敬
  • Journal Title: 日獨医報 Volume: 59 Pages: 124-137
• [Journal Article] CEST －CESTイメージングの臨床応用とその課題 (2014)
  • Author(s): 栂尾理，樋渡昭雄，山下孝二，菊地一史，本田浩，吉浦敬，鈴木由里子，Jochen Keupp
  • Journal Title: インナービジョン Volume: 9 Pages: 10-14
• [Presentation] Chemical exchange saturation transfer (CEST) imaging (2016)
  • Author(s): 吉浦 敬
  • Organizer: The 6th International Society of Radiation Neurobiology Conference
  • Place of Presentation: 長崎大学（長崎県長崎市）
  • Year and Date: 2016-02-12
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of the novel method for the measurement of brain amyloid burden (2015)
  • Author(s): 馬場 眞吾
  • Organizer: 55th Annual Meeting of JSNM
  • Place of Presentation: ハイアットリージェンシー東京（東京都新宿区）
  • Year and Date: 2015-11-05
• [Presentation] CEST/APTの臨床応用 (2015)
  • Author(s): 吉浦 敬
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームホテル（東京都文京区）
  • Year and Date: 2015-09-10
• [Presentation] Evaluation of cortical uptake of amyloid PET tracer with hybrid (2015)
  • Author(s): 馬場 眞吾
  • Organizer: Annual Meeting of SNMMI
  • Place of Presentation: Baltimore（アメリカ合衆国）
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] Estimation of the effect of cranial bone in the MR based attenuation correction: evaluation using 3D brain phantom (2014)
  • Author(s): Baba S, Isoda T, Maruoka Y, Kitamura Y, Kamei R, Sagiyama K, Watanabe Y, Honda H
  • Organizer: 54th annual meeting of JSNM
  • Place of Presentation: 大阪市 大阪国際会議場
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] Chemical Exchange Saturation Transfer （CEST）イメージング (2014)
  • Author(s): 吉浦敬
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡市 福岡国際会議場
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] Amide Proton Transferにおける飽和パルスの印加時間がCEST効果に及ぼす影響 (2014)
  • Author(s): 和田達弘、栂尾 理、他
  • Organizer: 第70回日本放射線技術学会総会学術大会
  • Place of Presentation: 横浜市 パシフィコ横浜
  • Year and Date: 2014-04-10 – 2014-04-13