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Developing the method of diagnosis using ultrasound microscopy

Research Project

Project/Area Number 26670565
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionJichi Medical University

Principal Investigator

Hideki Kumagai  自治医科大学, 医学部, 准教授 (60364353)

Co-Investigator(Kenkyū-buntansha) 伊東 紘一  自治医科大学, 医学部, 名誉教授 (60095007)
谷口 信行  自治医科大学, 医学部, 教授 (10245053)
Co-Investigator(Renkei-kenkyūsha) ITHO Koichi  自治医科大学, 医学部, 名誉教授 (60095007)
TANIGUCHI Nobuyuki  自治医科大学, 医学部, 教授 (10245053)
Research Collaborator KOBAYASHI Kazuto  本多電子株式会社
YOSHIDA Sachiko  豊橋技術科学大学, 環境生命工学系
YAMADA Hikari  豊橋技術科学大学, 環境生命工学系
IWAMOTO Saki  豊橋技術科学大学, 環境生命工学系
RAHMA H Rahayu  豊橋技術科学大学, 環境生命工学系
HIROTA Norio  株式会社廣田外科病理研究所
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords超音波顕微鏡 / 非アルコール性脂肪肝
Outline of Final Research Achievements

We used steatohepatitis mouse-models to compare the pathologic findings of the liver between using an ultrasound microscope and using a conventional microscope. We also observed paraffin embedded specimens from the large intestine of a child suffering from Hirschsprung’s disease.
Based on the deposition rate of fat as well as the degree of fibrosis, the graphical findings from the liver using the ultrasound microscopy were different from those using the conventional microscopy. Thus, it was difficult to evaluate the pathological grade of steatohepatitis based on the ultrasound intensity. On the other hand, impedance of the liver showed that it temporarily decreased with fat deposition level and then increased depending on the advancement of inflammation or fibrosis. During the observation of the large intestine, we could see the mucosal layer and muscular layer clearly using the ultrasound microscopy, and even identify the ganglion cells using 320 MHz ultrasound probe.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] 超音波顕微鏡の臨床応用の可能性2016

    • Author(s)
      熊谷秀規,横山孝二,今川智之,吉田祥子,小林和人,山形崇倫
    • Organizer
      第43回日本小児栄養消化器肝臓学会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児の生検診断における侵襲性低減への挑戦: - 超音波病理組織診断学の確立 -2016

    • Author(s)
      熊谷秀規
    • Organizer
      (公財)川 野 小 児 医 学 奨 学 財 団 第26回研 究 成 果 発 表 会
    • Place of Presentation
      ヤオコー本部ビル(川越市)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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