Biomarker research for PD-1 inhibitor and new combination therapy anti-PD-1 and chemotherapeutic agents
| Project/Area Number |
26670583
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
Maehara Yoshihiko 九州大学, 医学(系)研究科(研究院), 教授 (80165662)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Tetsuo 九州大学, 大学病院, 准教授 (60585701)
KAWANAKA Hirofumi 国立病院機構別府医療センター, その他, 臨床研究部長 (10363334)
OKI Eiji 九州大学, 大学病院, 講師 (70380392)
OKANO Shinji 九州大学, 医学(系)研究科(研究院), 准教授 (10380429)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫チェックポイント阻害剤 / 大腸癌 / バイオマーカー / PD-1 / PD-L1 |
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| Outline of Final Research Achievements |
The treatment of anti-PD-1 antibody and chemotherapy, FOLFIRI, showed synergistic tumor growth inhibition in wild type mice. The anti-tumor effects of anti-PD-1 antibody were cancelled in the Balb/c nude mice, suggesting the anti-tumor effects were dependet on T cells. Interestingly, PD-1-sensitive naturally occurring tumor reactive T cells were induced in unteated mice bearing CT26. On the other hand, high dose release of tumor antigens from cancer cells destructed by chemotherapy could induce a number of PD-1/PD-L1-insensitive tumor reactive T cells in lymphoid organs. Furthermore, we found that in vivo anti-PD-1 antibody treatment had a novel effect; the recruitment of effector T cells in the tumor sites, in addition to local suppression of the effector function of T cells.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Prognostic impact of programmed cell death 1 ligand 1 expression in human leukocyte antigen class I-positive hepatocellular carcinoma after curative hepatectomy.2014
Author(s)
Umemoto Y, Okano S, Matsumoto Y, Nakagawara H, Matono R, Yoshiya S, Yamashita YI, Yoshizumi T, Ikegami T, Soejima Y, Harada M, Aishima S, Oda Y, Shirabe K, Maehara Y.
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Journal Title
J Gastroenterol.
Volume: not determined
Issue: 1
Pages: 65-75
DOI
Related Report
Peer Reviewed / Open Access
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