| Project/Area Number |
26670583
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
Maehara Yoshihiko 九州大学, 医学(系)研究科(研究院), 教授 (80165662)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Tetsuo 九州大学, 大学病院, 准教授 (60585701)
KAWANAKA Hirofumi 国立病院機構別府医療センター, その他, 臨床研究部長 (10363334)
OKI Eiji 九州大学, 大学病院, 講師 (70380392)
OKANO Shinji 九州大学, 医学(系)研究科(研究院), 准教授 (10380429)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫チェックポイント阻害剤 / 大腸癌 / バイオマーカー / PD-1 / PD-L1 |
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| Outline of Final Research Achievements |
The treatment of anti-PD-1 antibody and chemotherapy, FOLFIRI, showed synergistic tumor growth inhibition in wild type mice. The anti-tumor effects of anti-PD-1 antibody were cancelled in the Balb/c nude mice, suggesting the anti-tumor effects were dependet on T cells. Interestingly, PD-1-sensitive naturally occurring tumor reactive T cells were induced in unteated mice bearing CT26. On the other hand, high dose release of tumor antigens from cancer cells destructed by chemotherapy could induce a number of PD-1/PD-L1-insensitive tumor reactive T cells in lymphoid organs. Furthermore, we found that in vivo anti-PD-1 antibody treatment had a novel effect; the recruitment of effector T cells in the tumor sites, in addition to local suppression of the effector function of T cells.
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