Identification of new chemical compound to induce pancreatic beta-cells

• Project/Area Number: 26670603
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Osaka University
• Principal Investigator: SAKAI Daisuke 大阪大学, 医学(系)研究科(研究院), 寄附講座助教 (10621071)
• Co-Investigator(Kenkyū-buntansha): ISHII Hideshi 大阪大学, 大学院医学系研究科, 特任教授 (10280736) ; KONNO Masamitsu 大阪大学, 大学院医学系研究科, 寄附講座助教 (80618207)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 再生医学 / 糖尿病 / 発生・分化

Outline of Final Research Achievements

We confirmed the differentiation efficiency to pancreatic beta-cell of chemical compounds using adipose derived mesenchymal stem cells. Identified chemical compounds were injected in ob/ob mouse and diabetes mellitus mouse. And we checked the blood glucose level of these mouse. It was showed that a few compounds were effective to treat the diabetes mellitus.

Research Products

• [Journal Article] BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer. (2016)
  • Author(s): Sueda, T., Sakai, D., Kawamoto, K., Konno, M., Nishida, N., Koseki, J., Colvin, S. H., Takahashi, H., Haraguchi, N., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Satoh, T., Doki, Y., Mori, M., Ishii, H.
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 18949-18949
  • DOI: 10.1038/srep18949
  • Peer Reviewed / Open Access
• [Journal Article] Safety and pharmacokinetics of S-1 in a recurrent colon cancer patient with chronic myeloid leukemia treated with dasatinib: A case report. (2014)
  • Author(s): Sueda T., Kudo T., Sakai D., Uemura M., Nishimura J., Hata T., Takemasa I., Mizushima T., Yamamoto H., Ezoe S., Matsumoto K., Doki Y., Mori M., Satoh T.
  • Journal Title: Cancer Chemother Pharmacol. Volume: 74 Issue: 6 Pages: 1321-1324
  • DOI: 10.1007/s00280-014-2620-8
  • Peer Reviewed