Strategy for epithelial thymic malignancy treatment focusing on L-type amino acid transporter 1
| Project/Area Number |
26670631
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory surgery
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Keitaro 獨協医科大学, 医学部, 准教授 (10323106)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 胸腺癌 / 胸腺腫 / アミノ酸トランスポーター / LAT1 / トランスポーター |
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| Outline of Final Research Achievements |
To evaluate the effect of L-type amino acid transporter 1 (LAT1) and cMyc-LAT1 axis in thymic carcinoma, we analyzed the function of LAT1 in Ty82 human thymic carcinoma cells. LAT1 was detected in Ty82 cells by Western blot. A LAT1-specific inhibitor, JPH203, reduced the cell growth of Ty82. JPH203 promoted the dephosphorylation of S6 kinase and phosphorylation of eukaryotic initiation factor 4E-binding protein 1, indicating that a LAT1-specific inhibitor inactivates mTOR, and leading to the suppressionof Ty82 cell proliferation. LAT1 was detected in human thymic carcinoma specimens, but not in those of thymoma.
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Report
(3 results)
Research Products
(3 results)
