The development of fluorescent-PET dual tracer for malignant gliomas
Project/Area Number |
26670642
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurosurgery
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Research Institution | Osaka University |
Principal Investigator |
Takano Koji 大阪大学, 医学系研究科, 招へい教員 (90649203)
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Co-Investigator(Kenkyū-buntansha) |
木下 学 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 脳神経外科副部長 (40448064)
畑澤 順 大阪大学, 医学系研究科, 教授 (70198745)
加藤 孝一 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
辻 厚至 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, チームリーダー(定常) (60303559)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | ALA / PET / 脳腫瘍 / 術中蛍光診断 / 術前画像診断 / chemical imaging / molecular imaging / ナビゲーション / ALA / PET |
Outline of Final Research Achievements |
This research aimed at developing a new PET tracer, which clarifies the correlation between intraoperative fluorescence diagnosis using 5-ALA and preoperative image diagnosis using MRI or PET (FDG, 11C-Methionine, etc.). As the candidate, a newly developed PET tracer, MALA (derivative of 5-ALA) was analyzed in vitro and in vivo. As a result, it was confirmed that MALA accumulates in a malignant tumor cell line, and that MALA accumulation significantly correlates with the accumulation of PPIX, a tracer for intraoperative fluorescence diagnosis using 5-ALA. MALA could be the PET tracer consistent with the purpose.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Voxel-Based Lesion Mapping of Cryptogenic Stroke in Patients with Advanced Cancer: A Detailed Magnetic Resonance Imaging Analysis of Distribution Pattern2017
Author(s)
Achiha T, Takagaki M, Oe H, Sakai M, Matsui H, Nakanishi K, Ozaki T, Fujimoto Y, Yoshimine T, Nakanishi K, Kinoshita M
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Journal Title
J Stroke Cerebrovasc Dis
Volume: Epub ahead of print
Issue: 7
Pages: 1521-1527
DOI
Related Report
Peer Reviewed
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[Journal Article] Introduction of High Throughput Magnetic Resonance T2-Weighted Image Texture Analysis for WHO Grade 2 and 3 Gliomas.2016
Author(s)
Kinoshita M, Sakai M, Arita H, Shofuda T, Chiba Y, Kagawa N, Watanabe Y, Hashimoto N, Fujimoto Y, Yoshimine T, Nakanishi K, Kanemura Y.
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Journal Title
PLoS One
Volume: 11
Issue: 10
Pages: e0164268-e0164268
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Diagnostic and Prognostic Value of 11C-Methionine PET for Nonenhancing Gliomas.2016
Author(s)
Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T.
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Journal Title
AJNR Am J Neuroradiol
Volume: 37
Issue: 1
Pages: 44-50
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] adiogenomics解析を目指した WHOグレード2、3神経膠腫の MRIテクスチャ解析2016
Author(s)
木下 学, 酒井 美緒, 有田 英之, 千葉 泰良, 香川 尚己, 渡辺 嘉之, 橋本 直哉, 藤本 康倫, 吉峰 俊樹, 中西 克之, 金村 米博
Organizer
日本脳神経外科学会第75回学術総会
Place of Presentation
福岡
Year and Date
2016-09-29
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