| Project/Area Number |
26670642
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
Takano Koji 大阪大学, 医学系研究科, 招へい教員 (90649203)
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| Co-Investigator(Kenkyū-buntansha) |
木下 学 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 脳神経外科副部長 (40448064)
畑澤 順 大阪大学, 医学系研究科, 教授 (70198745)
加藤 孝一 国立研究開発法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, 室長 (50382198)
辻 厚至 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, チームリーダー(定常) (60303559)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ALA / PET / 脳腫瘍 / 術中蛍光診断 / 術前画像診断 / chemical imaging / molecular imaging / ナビゲーション / ＡＬＡ / ＰＥＴ |
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| Outline of Final Research Achievements |
This research aimed at developing a new PET tracer, which clarifies the correlation between intraoperative fluorescence diagnosis using 5-ALA and preoperative image diagnosis using MRI or PET (FDG, 11C-Methionine, etc.). As the candidate, a newly developed PET tracer, MALA (derivative of 5-ALA) was analyzed in vitro and in vivo. As a result, it was confirmed that MALA accumulates in a malignant tumor cell line, and that MALA accumulation significantly correlates with the accumulation of PPIX, a tracer for intraoperative fluorescence diagnosis using 5-ALA. MALA could be the PET tracer consistent with the purpose.
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