Development of a bifunctional, anti-resorptive and pro-ostegenic, compound

Research Project

Project/Area Number	26670656
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Orthopaedic surgery
Research Institution	The University of Tokyo
Principal Investigator	Honma Masashi 東京大学, 医学部附属病院, 特任准教授 (60401072)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	シグナル伝達 / 骨代謝 / ナノ材料
Outline of Final Research Achievements	RANKL is widely recognized as a signal input molecule to stimulate osteoclastogenesis, however; we have found that the osteoblastic RANKL acts as an osteogenic signal acceptor for RANK incorporated into osteoclastic exosomes. In the present study, we aimed to develop a polymeric compound which mimics the properties of osteclastic exosomes which enable both the inhibition of RANKL forward signaling and the stimulation of RANKL reverse signaling. N-terminal biotinylation of W9 peptide, which has been shown to bind RANKL extracellular domain, resulted in the significant increase of pharmacological effect of W9 peptide.

Report

(3 results)