Development of a bifunctional, anti-resorptive and pro-ostegenic, compound
Project/Area Number |
26670656
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | The University of Tokyo |
Principal Investigator |
Honma Masashi 東京大学, 医学部附属病院, 特任准教授 (60401072)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | シグナル伝達 / 骨代謝 / ナノ材料 |
Outline of Final Research Achievements |
RANKL is widely recognized as a signal input molecule to stimulate osteoclastogenesis, however; we have found that the osteoblastic RANKL acts as an osteogenic signal acceptor for RANK incorporated into osteoclastic exosomes. In the present study, we aimed to develop a polymeric compound which mimics the properties of osteclastic exosomes which enable both the inhibition of RANKL forward signaling and the stimulation of RANKL reverse signaling. N-terminal biotinylation of W9 peptide, which has been shown to bind RANKL extracellular domain, resulted in the significant increase of pharmacological effect of W9 peptide.
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Report
(3 results)
Research Products
(1 results)