Development of oxygen gas-filled microparticles providing intravenous oxygen deelivery

• Project/Area Number: 26670693
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Kansai Medical University
• Principal Investigator: HIROTA Kiichi 関西医科大学, 医学部, 准教授 (00283606)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 低酸素血症 / 脂質二重膜酸素封入微小バブル / HIF-1 / 窒息 / 酸素 / マイクロバブル / 周術期低酸素 / 低酸素誘導性因子1 / 酸素担体

Outline of Final Research Achievements

The clinical concequence after prolonged oxygen deprivation due to severe hypoxemia can be serious, including cardiac arrest and brain damage and the most significant problem in the operating theather around the world. In these situations, patients are typically fed oxygen through endotracheal tube via the mouth. Severely hypoxemic patients are typically treated with inspired oxygen, intubation, and mechanical ventilation. At this moment, few other options to overcome the event exist. Now, safe and effective intravascular delivery of oxygen gas has not been realized. In this study, we tried to develop lipidic oxygen－containing microparticles that can be injected into the veins for systemic delivery of oxygen to all of the vital organs.

Research Products

• [Journal Article] UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha (2015)
  • Author(s): Goto Y, Zeng L, YeomCJ, Zhu Y, Morinibu A, Shinoyam K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H.
  • Journal Title: Nat Commun Volume: 6 Issue: 1 Pages: 1-10
  • DOI: 10.1038/ncomms7153
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of hypozia-inducible factors in the dysregulation of oxygen homeostasis in sepsis (2015)
  • Author(s): Hirota K.
  • Journal Title: Cardiovascular & hematological disorders drug targets Volume: 15 Issue: 1 Pages: 29-40
  • DOI: 10.2174/1871529x15666150108115553
  • Peer Reviewed / Open Access
• [Journal Article] Volatile anesthetics suppress glucose-stimulated insulin secretion in MIN6 cells by inhibiting glucose-induced activation of hypoxia-inducible factor 1. (2015)
  • Author(s): Suzuki K, Sato Y, Kai S, Nishi K, Adachi T, Matsuo Y, Hirota K.
  • Journal Title: PeerJ. Volume: 3 Pages: 1498-1498
  • DOI: 10.7717/peerj.1498
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis. (2014)
  • Author(s): Zeng L, Morinibu A, Kobayashi M, Zhu Y, Wang X, Goto Y, Yeom CJ, Zhao T,Hirota K, Shinomiya K, Itasaka S, Yoshimura M, Guo G, Hammond EM, Hiraoka M, Harada H.
  • Journal Title: Oncogene Volume: epub Issue: 36 Pages: 4758-4766
  • DOI: 10.1038/onc.2014.411
  • Peer Reviewed / Open Access
• [Journal Article] 肺胞低酸素と炎症 -低酸素誘導性因子活性化の視点から- (2014)
  • Author(s): 広田 喜一
  • Journal Title: 分子呼吸器病 Volume: 18 Pages: 73-75
• [Journal Article] 肺内酸素環境と肺疾患 -低酸素-HIF-炎症- (2014)
  • Author(s): 広田 喜一
  • Journal Title: 呼吸器内科 Volume: 25 Pages: 270-275
• [Journal Article] The volatile anesthetic isoflurane differentially suppresses the induction of erythropoietin synthesis elicited by acute anemia and systemic hypoxemia in mice in an hypoxia-inducible factor-2-dependent manner. (2014)
  • Author(s): Kai S, Tanaka T, Matsuyama T, Suzuki K, Hirota K.
  • Journal Title: Eur J Pharmacol. Volume: 732C Pages: 43-49
  • DOI: 10.1016/j.ejphar.2014.03.020
  • Peer Reviewed