Analysis of Pathogenesis and disease marker of ocular surface inflammatory diseases using lipid metabolomics

• Project/Area Number: 26670758
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KINOSHITA SHIGERU 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30116024)
• Co-Investigator(Kenkyū-buntansha): SAITOU Yoshirou 国立医薬品食品衛生研究所, 医薬安全科学部, 部長 (50215571) ; UETA Mayumi 京都府立医科大学, 医学研究科, 准教授 (60398386)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 眼表面炎症性疾患 / 脂質メディエーター / メタボロミクス / 脂質 / 眼表面炎症

Outline of Final Research Achievements

We analyzed the lipid mediator of ocular surface inflammatory diseases using lipid metabolomics techniques and elucidate the plasma lipid profiling of atopic keratoconjunctivitis , eye complications type Stevens-Johnson syndrome, and healthy controls. We also compare between each ocular surface inflammatory disease and normal controls, and between various ocular surface inflammatory diseases, and found the difference in ocular surface inflammatory diseases. We also identified the molecules involved in the pathogenesis of ocular surface inflammatory diseases and the related specific marker of them.

Research Products

• [Journal Article] Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. (2016)
  • Author(s): 2.Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J.
  • Journal Title: Ocul Surf. Volume: 14(2) Issue: 2 Pages: 00011-2
  • DOI: 10.1016/j.jtos.2016.02.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stevens Johnsons Syndrome: The Role of an Ophthalmologist. (2016)
  • Author(s): 3.Jain R, Sharma N, Basu S, Iyer G, Ueta M, Sotozono C, Kannibiran C, Rathi VM, Gupta N, Kinoshita S, Gomes JA, Chodosh J, Sangwan VS.
  • Journal Title: Surv Ophthalmol Volume: - Issue: 4 Pages: 168-88
  • DOI: 10.1016/j.survophthal.2016.01.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease. (2016)
  • Author(s): 4.Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J.
  • Journal Title: Ocul Surf Volume: 14(1) Issue: 1 Pages: 2-19
  • DOI: 10.1016/j.jtos.2015.10.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. (2014)
  • Author(s): Ueta M, Shoji J, Sotozono C, Kinoshita K.
  • Journal Title: Clinical and Translational Allergy Volume: 4 Issue: 1 Pages: 40-40
  • DOI: 10.1186/2045-7022-4-40
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Suppressive effects of IL-8, ECP and total IgE in the tear of atopic keratoconjunctivitis by rebamipide eye drops. (2014)
  • Author(s): Mayumi Ueta, Jun Shoji, Chie Sotozono, Norihiko Yokoi, Shigeru Kinoshita.
  • Organizer: The European Academy of Allergy and Clinical Immunology Congress 2014(EAACI 2014)
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-06-10