Autologus adipose-derived stem cell therapy for radiation injuries

• Project/Area Number: 26670774
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Nagasaki University
• Principal Investigator: YOSHIMOTO Hiroshi 長崎大学, 病院(医学系), 助教 (90513309)
• Co-Investigator(Kenkyū-buntansha): AKITA Sadanori 長﨑大学, 病院(医学系), 講師 (90315250)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脂肪由来幹細胞 / 創傷治癒 / 放射線皮膚障害 / 放射線照射 / 放射線潰瘍 / 放射線再照射

Outline of Final Research Achievements

We recognized the improvement of ischemia and edema each with adipose-derived stem cells transplantation in a lower extremity ischemia rat or a lower extremity lymphedema mouse which are an animal model of the radiation injury. We also recognized a further improvement effect in combination of vascularized tissue transplantation and adipose-derived stem cells transplantation than adipose-derived stem cells alone transplantation.
Radiation wounds are usually treated with adequate debridement and vascularized tissues transplantation. We think a further improvement effect in combination of vascularized tissue transplantation and adipose-derived stem cells transplantation for treatment of radiation injury.

Research Products

• [Journal Article] Wound healing and angiogenesis through combined use of a vascularized tissue flap and adipose-derived stem cells in a rat hindlimb irradiated ischemia model (2016)
  • Author(s): Yoshida S, Yoshimoto H, Hirano A and Akita S
  • Journal Title: Plast Reconstr Surg Volume: 137(5) Pages: 1486-1497
  • Peer Reviewed
• [Journal Article] Adipose-derived stem cell transplantation for therapeutic lymphangiogenesis in a mouse secondary lymphedema model (2015)
  • Author(s): Yoshida S, Hamuy R, Hamada Y, Yoshimoto H, Hirano A and Akita S
  • Journal Title: Regen Med Volume: 10 Pages: 549-562
  • Peer Reviewed
• [Journal Article] Vascular malformations that were diagnosed as or accompanied by malignant tumors. (2014)
  • Author(s): Houbara S, Akita S, Yoshimoto H, Hirano A.
  • Journal Title: Dermatol Surg. Volume: 40(11) Issue: 11 Pages: 1225-1232
  • DOI: 10.1097/dss.0000000000000145
  • Peer Reviewed
• [Journal Article] Lipid-colloid dressing shows improved reepithelialization, pain relief, and corneal barrier function in split-thickness skin-graft donor wound healing. (2014)
  • Author(s): Tanaka K, Akita S, Yoshimoto H, Houbara S, Hirano A.
  • Journal Title: Int J Low Extrem Wounds Volume: 23(10) Issue: 3 Pages: 220-225
  • DOI: 10.1177/1534734614541544
  • Peer Reviewed
• [Presentation] 当科関連施設における培養表皮移植における実践的な問題検討について (2015)
  • Author(s): 大石正雄、秋田定伯、吉本 浩、千住千佳子、平野明喜、藤岡正樹、林田健志、諸岡 真、西村剛三、迎 伸彦、池野屋慎太郎、小林一夫、村上隆一、安楽邦明
  • Organizer: 第41回日本熱傷学会総会・学術集会
  • Place of Presentation: 名古屋市（名古屋観光ホテル）
  • Year and Date: 2015-06-18
• [Book] Skin necrosis (2015)
  • Author(s): Teot L, Meaume S, Del Mamol V, Akita S and Ennis WI
  • Total Pages: 3
  • Publisher: Springer-Verlag