Blood purification for sepsis-induced immunoparalysis
| Project/Area Number |
26670795
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
ONO SATOSHI 東京医科大学, 医学部, 教授 (30531355)
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| Co-Investigator(Kenkyū-buntansha) |
池田 寿昭 東京医科大学, 医学部, 教授 (90246182)
辻本 広紀 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医療安全・感染対策部, 教授 (80554998)
木下 学 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 免疫・微生物学, 准教授 (70531391)
宮崎 裕美 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター 外傷研究部門, 助教 (30531636)
平木 修一 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 助教 (40638839)
青笹 季文 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 講師 (40649034)
山本 順司 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 教授 (40342654)
齋藤 大蔵 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター 外傷研究部門, 教授 (90531632)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 敗血症 / 免疫麻痺 / エンドトキシン / 血液浄化療法 / 敗血症性免疫不全 / 動物敗血症モデル / IFN-γ / 小動物用カラム / NK細胞 / ポリミキシンB |
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| Outline of Final Research Achievements |
Sepsis is a common and frequently fatal clinical condition in critically ill patients. This profound proinflammatory state is rapidly counterbalanced by an anti-inflammatory response, which may adversely affect immune functions. This state of secondary immunoparalysis is first characterized by monocytic deactivation: decreasing antigen presenting capacity, phagocytic function, and proinflammatory cytokine release. Polymyxin B has long been known to neutralize the various biological activities of endotoxin. We found a major increase in the percentage of Tregs in peripheral blood circulating CD4+T cells from patients with septic shock. We revealed that Polymyxin B might decrease peripheral blood circulating Treg cells and directly increase the IFN-r production from peripheral blood mononuclear cells. Removal of Tregs by hemoperfusion with Polymyxin B-immobilized fibers might represent a novel strategy for inducing recovery from the immunosuppression associated with sepsis.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Theranostic photosensitive nanoparticles for lymph node metastatis of gastric cancer2015
Author(s)
Tsujimoto, H., Morimoto, Y., Takahata, R., Nomura, S., Yoshida, K., Hiraki, S., Horiguchi, H., Miyazaki, H., Ono, S., Saito, D., Hara, I., Ozeki, E., Yamamoto, J., Hase, K.
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Journal Title
Annals of surgical oncology
Volume: 22
Related Report
Peer Reviewed
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[Journal Article] Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model.2015
Author(s)
Matsumoto Y, Tsujimoto H, Ono S, Shinomiya N, Miyazaki H, Hiraki S, Takahata R, Yoshida K, Saitoh D, Yamori T, Yamamoto J, Hase K.
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Journal Title
Annals of surgical oncology
Volume: 23
Pages: 257-265
Related Report
Peer Reviewed
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[Presentation] 術後感染症と腸管免疫2016
Author(s)
小野 聡
Organizer
第29回日本外科感染症学会総会
Place of Presentation
新宿京王プラザホテル
Year and Date
2016-11-29
Related Report
Invited
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[Presentation] 外科侵襲と腸管免疫2015
Author(s)
小野 聡
Organizer
第21回日本エンドトキシン・自然免疫研究会
Place of Presentation
東京
Year and Date
2015-12-05
Related Report
Invited
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