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Blood purification for sepsis-induced immunoparalysis

Research Project

Project/Area Number 26670795
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionTokyo Medical University

Principal Investigator

ONO SATOSHI  東京医科大学, 医学部, 教授 (30531355)

Co-Investigator(Kenkyū-buntansha) 池田 寿昭  東京医科大学, 医学部, 教授 (90246182)
辻本 広紀  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医療安全・感染対策部, 教授 (80554998)
木下 学  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 免疫・微生物学, 准教授 (70531391)
宮崎 裕美  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター 外傷研究部門, 助教 (30531636)
平木 修一  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 助教 (40638839)
青笹 季文  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 講師 (40649034)
山本 順司  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 外科学, 教授 (40342654)
齋藤 大蔵  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 防衛医学研究センター 外傷研究部門, 教授 (90531632)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords敗血症 / 免疫麻痺 / エンドトキシン / 血液浄化療法 / 敗血症性免疫不全 / 動物敗血症モデル / IFN-γ / 小動物用カラム / NK細胞 / ポリミキシンB
Outline of Final Research Achievements

Sepsis is a common and frequently fatal clinical condition in critically ill patients.  This profound proinflammatory state is rapidly counterbalanced by an anti-inflammatory response, which may adversely affect immune functions. This state of secondary immunoparalysis is first characterized by monocytic deactivation: decreasing antigen presenting capacity, phagocytic function, and proinflammatory cytokine release.  Polymyxin B has long been known to neutralize the various biological activities of endotoxin. We found a major increase in the percentage of Tregs in peripheral blood circulating CD4+T cells from patients with septic shock. We revealed that Polymyxin B might decrease peripheral blood circulating Treg cells and directly increase the IFN-r production from peripheral blood mononuclear cells. Removal of Tregs by hemoperfusion with Polymyxin B-immobilized fibers might represent a novel strategy for inducing recovery from the immunosuppression associated with sepsis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (29 results)

All 2017 2016 2015 2014

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (14 results) (of which Invited: 12 results) Book (3 results)

  • [Journal Article] Perioperative chemoradiation therapy for esophageal cancer is a risk factor for the elevation of high mobilitygroup box-1, leading to an increase in postoerative severe pulmonary complications2016

    • Author(s)
      Takahata R, Ono S, Tsujimoto H, Hiraki S, Aosasa S, Yamamoto J, Hase K
    • Journal Title

      Dis Esophagus

      Volume: 29 Pages: 70-78

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 外科侵襲時の免疫不全の病態と癌手術患者の長期予後2016

    • Author(s)
      小野 聡、辻本広紀
    • Journal Title

      外科と代謝栄養

      Volume: 50 Pages: 265-277

    • NAID

      130005308707

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 周術期生体反応の特性と感染性合併症対策2016

    • Author(s)
      小野 聡
    • Journal Title

      東京医科大学雑誌

      Volume: 74 Pages: 123-135

    • NAID

      120005845840

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ショック患者における輸液療法の実際2016

    • Author(s)
      小野 聡、須田慎吾、奈倉武郎、池田寿昭
    • Journal Title

      救急医学

      Volume: 40 Pages: 1633-1640

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Perioperative programmed death-1 expression on CD4+ T cells predicts the incidence of postoperative infectious complications2015

    • Author(s)
      Kubo T, Ono S, Miyazaki H, Saitoh D, Yamamoto J, Hase K.
    • Journal Title

      Shock

      Volume: 44 Pages: 323-329

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Theranostic photosensitive nanoparticles for lymph node metastatis of gastric cancer2015

    • Author(s)
      Tsujimoto, H., Morimoto, Y., Takahata, R., Nomura, S., Yoshida, K., Hiraki, S., Horiguchi, H., Miyazaki, H., Ono, S., Saito, D., Hara, I., Ozeki, E., Yamamoto, J., Hase, K.
    • Journal Title

      Annals of surgical oncology

      Volume: 22

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abdominal Infection Suppresses the Number and Activity of Intrahepatic Natural Killer Cells and Promotes Tumor Growth in a Murine Liver Metastasis Model.2015

    • Author(s)
      Matsumoto Y, Tsujimoto H, Ono S, Shinomiya N, Miyazaki H, Hiraki S, Takahata R, Yoshida K, Saitoh D, Yamori T, Yamamoto J, Hase K.
    • Journal Title

      Annals of surgical oncology

      Volume: 23 Pages: 257-265

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Burn-evoked reactive oxygen species immediately after injury are crucial to restore the neutrophil function against post-burn infection in mice2015

    • Author(s)
      Miyazaki H, Kinoshita M, Ono S, Seki S, Saitoh D.
    • Journal Title

      Shock

      Volume: 44 Pages: 252-257

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 重症感染症における免疫療法の意義2015

    • Author(s)
      小野 聡、池田寿昭、須田慎吾、泉谷義人、上野琢哉
    • Journal Title

      ICUとCCU

      Volume: 39 Pages: 423-429

    • Related Report
      2015 Research-status Report
  • [Journal Article] Impact of the perioperative neutrophil-to-lymphocyte ratio on the long-term survival following an elective resection of colorectal carcinoma2014

    • Author(s)
      Kubo T, Ono S, Ueno H, Shinto E, Yamamoto J, Hase K
    • Journal Title

      Int J Colorectal Dis

      Volume: 29 Pages: 1091-1099

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perioperative chemoradiation therapy for esophageal cancer is a risk factor for the elevation of high mobilitygroup box-1, leading to an increase in postoerative severe pulmonary complications2014

    • Author(s)
      Takahata R, Ono S, Tsujimoto H, Hiraki S, Aosasa S, Yamamoto J, Hase K
    • Journal Title

      Dis Esophagus

      Volume: - Issue: 1 Pages: 70-78

    • DOI

      10.1111/dote.12261

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 急性血液浄化法 IV. 急性血液浄化法の適応疾患 重症壊死性筋膜炎に対する血液浄化2014

    • Author(s)
      池田寿昭、小野 聡、上野琢哉
    • Journal Title

      救急・集中治療

      Volume: 26 Pages: 449-457

    • Related Report
      2014 Research-status Report
  • [Presentation] 外科的感染症のDNA診断・血清診断の有用性2017

    • Author(s)
      小野 聡、須田慎吾、奈倉武郎、池田寿昭
    • Organizer
      第44回日本集中治療医学会学術集会
    • Place of Presentation
      札幌市教育文化会館
    • Year and Date
      2017-03-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 敗血症性免疫不全の病態と今後の治療戦略2017

    • Author(s)
      小野 聡
    • Organizer
      第22回新都心集中治療カンファレンス
    • Place of Presentation
      新宿京王プラザホテル
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 術後感染症と腸管免疫2016

    • Author(s)
      小野 聡
    • Organizer
      第29回日本外科感染症学会総会
    • Place of Presentation
      新宿京王プラザホテル
    • Year and Date
      2016-11-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] sepsisの新しい定義を読み解く2016

    • Author(s)
      小野 聡
    • Organizer
      第25回日本集中治療医学会関東甲信越地方会
    • Place of Presentation
      帝京大学
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Sepsisの新しい定義とsepsis治療の新たな展開2016

    • Author(s)
      小野 聡
    • Organizer
      セプシスカンファレンスin広島2016
    • Place of Presentation
      広島
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 外科侵襲と腸管免疫2015

    • Author(s)
      小野 聡
    • Organizer
      第21回日本エンドトキシン・自然免疫研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 外科からみた周術期感染管理2015

    • Author(s)
      小野 聡
    • Organizer
      第213回ICD講習会
    • Place of Presentation
      東京
    • Year and Date
      2015-08-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] (シンポジウム)外科侵襲時の炎症・免疫担当細胞の役割と機能評価2015

    • Author(s)
      小野 聡、辻本広紀、平木修一、久保 徹、池田寿昭
    • Organizer
      外科代謝栄養学会第52回学術集会
    • Place of Presentation
      品川
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 重症敗血症治療におけるサイトカイン治療の新たな展開2015

    • Author(s)
      小野 聡
    • Organizer
      サイトカインストーム研究会
    • Place of Presentation
      宇都宮
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 敗血症性DICの病態解明とその対策2015

    • Author(s)
      小野 聡
    • Organizer
      広島DICフォーラム2015
    • Place of Presentation
      広島
    • Year and Date
      2015-06-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 白血球数はPMX-DHPの効果に影響を及ぼすか?2015

    • Author(s)
      山中浩史、池田寿昭、小野 聡、上野琢哉、須田慎吾
    • Organizer
      第42回日本集中治療医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-02-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 敗血症時の免疫機能低下の病態とモニタリング2015

    • Author(s)
      小野 聡
    • Organizer
      敗血症セミナー in 名古屋
    • Place of Presentation
      名古屋大学
    • Year and Date
      2015-01-10
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] (教育セミナー)免疫機能からみた術後感染性合併症のリスク評価と予測因子に関する検討2014

    • Author(s)
      小野 聡、久保 徹、高畑りさ、木村暁史、辻本広紀、青笹季文、長谷和生
    • Organizer
      第27回日本外科感染症学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-12-03 – 2014-12-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 敗血症性免疫不全状態におけるエンドトキシン吸着療法(PMX)の有効性発現機序に関する基礎的研究2014

    • Author(s)
      木村暁史、小野 聡、辻本広紀、平木修一、高畑りさ、青笹季文、初瀬一夫、齋藤大蔵、長谷和生、山本順司
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-04-04
    • Related Report
      2014 Research-status Report
  • [Book] エンドトキシン・自然免疫研究192016

    • Author(s)
      小野 聡、木下 学、池田寿昭
    • Total Pages
      60
    • Publisher
      医学図書出版
    • Related Report
      2016 Annual Research Report
  • [Book] 術後ケアとドレーン管理のすべて 編集:竹末芳生、藤野智子2016

    • Author(s)
      小野 聡、池田寿昭
    • Total Pages
      402
    • Publisher
      照林社
    • Related Report
      2016 Annual Research Report
  • [Book] 敗血症(セプシス)救命治療の最前線 竹末芳生編 セプシス治療薬 セプシス治療薬の日本での活用2014

    • Author(s)
      小野 聡
    • Total Pages
      397
    • Publisher
      医薬ジャーナル社
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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