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Golgi-localized Fam20C phosphorylation and osteocyte functions

Research Project

Project/Area Number 26670801
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

Toyosawa Satoru  大阪大学, 歯学研究科(研究院), 教授 (30243249)

Co-Investigator(Kenkyū-buntansha) SAEKI MAKIO  新潟大学, 医歯学系, 教授 (30273692)
SATO SUNAO  大阪大学, 歯学研究科, 講師 (70335660)
USAMI YU  大阪大学, 歯学部附属病院, 助教 (80444579)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsFam20C / リン酸化 / 骨細胞 / 骨芽細胞 / 骨基質蛋白質 / 骨基質 / DMP1
Outline of Final Research Achievements

Golgi-localized protein kinase Fam20C phosphorylates secretory pathway proteins with S-x-E/pS motifs. In the bone tissue, Fam20C is slightly expressed in the osteoblasts and highly expressed in the osteocytes. Therefore, the bone matrix proteins which are produced by osteoblasts and osteocytes, are phosphorylated by Fam20C within these cells. Considering that Fam20C-null mice have osteomalacia with decreased bone mineral density, these findings suggest that phosphorylation of these matrix proteins by Fam20C is critical for bone formation and maintenance. To understand the functional significance of phosphorylation for the bone matrix, we generated transgenic mice that had Fam20C-overexpression in osteoblasts (Fam20C-Tg mice), and we are examining the change of the bone tissues in Fam20C-Tg mice.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] Fam20C過剰発現マウスの骨組織の検討について2016

    • Author(s)
      廣瀬勝俊
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌)
    • Year and Date
      2016-08-24
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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