How is the formation site of osteoclasts determined?
| Project/Area Number |
26670814
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Nakamichi Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
Mizoguchi Toshihide 松本歯科大学, 総合歯科医学研究所, 講師 (90329475)
Hosoya Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
Kobayashi Yasuhiro 松本歯科大学, 総合歯科医学研究所, 教授 (20264252)
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| Co-Investigator(Renkei-kenkyūsha) |
Kawahara Ichiro 松本歯科大学, 歯学部, 教授 (20319114)
Udagawa Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 破骨細胞 / 骨芽細胞 / 破骨細胞前駆細胞 / RANKL / M-CSF / QOP / Wnt |
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| Outline of Final Research Achievements |
Why do osteoclasts formed only in the bone? It has been considered “ because osteoblasts express osteoclast differentiation factor RANKL and M-CSF." However, when RANKL and M-CSF are administered intraperitoneally to RANKL-deficient mice and M-CSF-deficient op/op mice, respectively, osteoclasts appear only in bone tissue. This indicates that expression sites of RANKL and M-CSF do not determine the formation site of osteoclasts. In the present study, we showed that osteoclast precursors (OP) which highly express RANK (RANK-abundant OP, rOP) are detected only in the bone tissue. Localization of rOP is shown to determine the formation site of osteoclasts.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization.2015
Author(s)
Kanemoto S, Kobayashi Y, Yamashita T, Miyamoto T, Cui M, Asada R, Cui X, Hino K, Kaneko M, Takai T, Matsuhisa K, Takahashi N, Imaizumi K.
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Journal Title
J Cell Sci
Volume: 128
Pages: 4353-4365
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
Author(s)
Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
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Journal Title
Sci. report
Volume: 4
Issue: 1
Pages: 4493-4493
DOI
Related Report
Peer Reviewed / Open Access
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