| Project/Area Number |
26670814
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Nakamichi Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
Mizoguchi Toshihide 松本歯科大学, 総合歯科医学研究所, 講師 (90329475)
Hosoya Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
Kobayashi Yasuhiro 松本歯科大学, 総合歯科医学研究所, 教授 (20264252)
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| Co-Investigator(Renkei-kenkyūsha) |
Kawahara Ichiro 松本歯科大学, 歯学部, 教授 (20319114)
Udagawa Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 破骨細胞 / 骨芽細胞 / 破骨細胞前駆細胞 / RANKL / M-CSF / QOP / Wnt |
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| Outline of Final Research Achievements |
Why do osteoclasts formed only in the bone? It has been considered “ because osteoblasts express osteoclast differentiation factor RANKL and M-CSF." However, when RANKL and M-CSF are administered intraperitoneally to RANKL-deficient mice and M-CSF-deficient op/op mice, respectively, osteoclasts appear only in bone tissue. This indicates that expression sites of RANKL and M-CSF do not determine the formation site of osteoclasts. In the present study, we showed that osteoclast precursors (OP) which highly express RANK (RANK-abundant OP, rOP) are detected only in the bone tissue. Localization of rOP is shown to determine the formation site of osteoclasts.
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