Development of novel anti-inflammatory therapy for apical periodontal disease using mesenchymal cell transplantation
| Project/Area Number |
26670823
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
Masahiro Saito 東北大学, 歯学研究科(研究院), 教授 (40215562)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA KYOKO 三重大学, 医学研究科, 准教授 (00242967)
KOBAYASHI YOKO 東北大学, 大学院歯学研究科, 助教 (50261524)
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO TADAO 東北大学, 農学部, 教授 (00118358)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 再生医療 / 細胞移植 / 抗炎症 / 細胞外マトリックス / 保存系歯学 / 動物モデル / 結合組織疾患 / 間葉系細胞 / 保存治療 / 歯内療法 / 細胞移植療法 / 自家移植 / 他家移植 / 抗炎症療法 |
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| Outline of Final Research Achievements |
In the present study, we attempt to develop anti-inflammatory therapy for apical periodontitis. To achieve this purposes, we investigate matricellular proteins which is a extracellular matrix involving acceleration of immune response. We found that reduced expression of fibrillin-1 that regulate tissue elasticity is excavated inflammatory response of periodontal tissue. From these findings, reduction of fibrillin-1 play an important role in the progression of apical periodontal disease.
We also established alveolar bone derived immature osteoblast obtained from human alveolar bone. These cells has a high osteogenic ability and bone forming ability in vivo. We are investigating anti-inflammatory effect of these cells.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts2016
Author(s)
Umeyama K, Watanabe K, Watanabe M, Horiuchi K, Nakano K, Kitashiro M, Matsunari H, Kimura T, Arima Y, Sampetrean O, Nagaya M, Saito M, Saya H, Kosaki K, Nagashima H & Matsumoto M
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Journal Title
Sci Rep.
Volume: 6:24413
Issue: 1
Pages: 1-4
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interaction between Fibronectin and β1 Integrin is Essential for Tooth Development.2015
Author(s)
Saito, K., Fukumoto, E., Yamada, A., Yuasa, K., Yoshizaki, K., Iwamoto, T., Saito, M., Nakamura, T., and Fukumoto, S.
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Journal Title
PLOS one
Volume: 10(4)
Issue: 4
Pages: 1-12
DOI
NAID
Related Report
Peer Reviewed / Open Access
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