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Investigation for the receptor of dental pulp cell-derived tumor necrosis factor-alpha inducing factor (DPTIF)

Research Project

Project/Area Number 26670824
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Conservative dentistry
Research InstitutionKyushu University

Principal Investigator

NISHIMURA FUSANORI  九州大学, 歯学研究院, 教授 (80208222)

Co-Investigator(Kenkyū-buntansha) 讃井 彰一  九州大学, 大学病院, 講師 (70507780)
福田 隆男  九州大学, 歯学研究院, 助教 (80507781)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯髄細胞 / 急性炎症 / マクロファージ / TNF-α / 内毒素 / 歯髄炎症 / 急性歯髄炎 / TNF-alpha
Outline of Final Research Achievements

We previously found that dental pulp cells produces molecules inducing tumor necrosis factor alpha from macrophages, and named this factor Dental Pulp Cell-derived Tumor Necrosis Factor-α Inducing Factor: DPTIF. In this study, we aimed to unvail the nature of this molecule and to investigate the posibble receptor and/or binding proteins. The results indicated that DPTIF contains trypsin sensitive protenous molecule but is associated with extracelluler microvesicles. Therefore, it appeared that DPTIF is directly incorporated into macrophages rather than binding to the cell surface receptor.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation.2017

    • Author(s)
      Takano A, Fukuda T, Shinjo T, Iwashita M, Matsuzaki E, Yamamichi K, Takeshita M, Sanui T, Nishimura F.
    • Journal Title

      Metabolism

      Volume: 69 Pages: 157-170

    • DOI

      10.1016/j.metabol.2017.01.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells2016

    • Author(s)
      Hashimoto, Y,. Kobayashi, M., Matsuzaki, E., Higashi, K., Takahashi-Yanaga, F., Takano, A., Hirata, M. and Nishimura, F.
    • Journal Title

      Cell Biol. Int.

      Volume: 40 Issue: 10 Pages: 1129-1136

    • DOI

      10.1002/cbin.10652

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts2016

    • Author(s)
      Higashi, K., Matsuzaki, E., Hashimoto, Y., Takahashi-Yanaga, F., Takano, A., Anan, H., Hirata, M. and Nishimura, F.
    • Journal Title

      Bone

      Volume: 93 Pages: 1-11

    • DOI

      10.1016/j.bone.2016.09.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2014-04-04   Modified: 2018-03-22  

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