| Project/Area Number |
26670852
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤原 尚樹 岩手医科大学, 歯学部, 准教授 (20190100)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 歯根膜 / 血管内皮前駆細胞 / 血管新生 / 造血能力 / 歯周組織再生 / 間葉系幹細胞 / 血管形成 / 血球細胞分化 |
|---|
| Outline of Final Research Achievements |
Aim of this study is establishment of novel therapy for regeneration of periodontal ligament (PDL) by application of the angiogenic and hematopoietic activities of PDL-derived cells.
Here, we found that hypoxic condition strongly promoted angiogenic and hematopoietic activities of the PDL-derived endothelial progenitor cells (EPCs) in the three-dimensional culture system by using type I collagen gel, which possibly facilitates identification of key genes for the expression of angiogenic and hematopoietic activities of these cells. In addition, we found that cell-cell interaction between EPCs and nerve cells possibly enhanced angiogenic and hematopoietic activities of EPCs. There is a possibility that establishment of microcirculation therapy through application of EPC―nerve cell network for angiogenesis and hematopoiesis.
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