Regeneration study of maxillofacial nerve using of artificial nerve tube with self mononuclear leukocyte (BMC) derived from bone marrow.

• Project/Area Number: 26670864
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyoto University
• Principal Investigator: Shigeno Keiji 京都大学, 再生医科学研究所, その他 (00162587)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA TATSUO 京都大学, 再生医科学研究所, 准教授 (70227908)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 人工神経管 / PGA-コラーゲンチューブ / 骨髄由来単核球(BMC) / 再生痛 / 神経再生実験 / 神経再生の質 / PGAコラーゲンチューブ / 神経再生 / 難治性神経因性疼痛 / 自己骨髄由来単核球 / 知覚神経 / 運動神経 / 混合神経 / 骨髄由来単核球 / 治癒促進能力

Outline of Final Research Achievements

We were able to confirm that the trigeminal nerve which controlled difficulty and the maxillofacial which had been done, the exercise of maxillofacial and perception corresponded, and regeneration could provide improvement of speed of the nerve regeneration and the quality until now by gathering mononuclear leukocyte (BMC) derived from dog marrow than a host in this study, and using it for nerve damage region with an artificial neural tube (P.G.A. collagen tube) which We developed in a laboratory. In addition, We were able to confirm that We restrained "a pain - regeneration pain” to develop in the case of neurologic regeneration healing by this experiment as much as possible and bring about prompt nerve regeneration.

Research Products

• [Journal Article] The efficacy of a novel collagen-gelatin scaffold with basic fibroblast growth factor for the treatment of vocal fold scar. (2016)
  • Author(s): Hiwatashi, N., Hirano, S., Mizuta, M., Kobayashi, T., Kawai, Y., Kanemaru, SI., Nakamura, T., Ito, J., Kawai, K., Suzuki, S.
  • Journal Title: J Tissue Eng Regen Med. Volume: in press Issue: 5 Pages: 0-0
  • DOI: 10.1002/term.2060
  • Peer Reviewed
• [Journal Article] 人工神経． (2015)
  • Author(s): 中村達雄
  • Journal Title: 人工臓器 Volume: 44 Pages: 164-168
  • NAID: 130005138134
• [Journal Article] A successful attempt to prevent postoperative adhesions between the mediastinum and a lung: a canine model. (2015)
  • Author(s): Hamaji, M., Nakamura, T.
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: 63 Issue: 8 Pages: 483-484
  • DOI: 10.1007/s11748-015-0563-6
  • NAID: 120005672616
  • Peer Reviewed
• [Journal Article] A rigid and bioabsorbble material for anterior chest wall reconstruction in a canine model. (2015)
  • Author(s): Hamaji, M., Kojima, F., Koyasu, S., Nobashi, T., Tsuruyama, T., Date, H., Nakamura, T.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 20 Issue: 3 Pages: 322-328
  • DOI: 10.1093/icvts/ivu416
  • Peer Reviewed / Open Access
• [Journal Article] Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury. (2015)
  • Author(s): Tamura, K., Harada, Y., Kunimi, M., Takemitsu, H., Hara, Y., Nakamura, T., Tagawa, M.
  • Journal Title: Exp Clin Transplant. Volume: 13 Pages: 100-5
  • Peer Reviewed / Open Access
• [Journal Article] Mechanical properties of a bioabsorbable nerve guide tube for long nerve defects. (2015)
  • Author(s): Ichihara, S., Facca, S., Liverneaux, P., Inada, Y., Takigawa, T., Kaneko, K., Nakamura, T.
  • Journal Title: Chir Main. Volume: 34 Issue: 4 Pages: 186-192
  • DOI: 10.1016/j.main.2015.05.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 三叉神経障害に対するPGA-C tubeによる生体内再生治療の高分解能神経MRIを用いた予後評価． (2015)
  • Author(s): 照光 真、瀬尾憲司、松澤 等、稲田有史、中村達雄、茂野啓示、渡辺将樹、鈴木清隆、中田 力
  • Journal Title: Peripheral Nerve Volume: 26 Pages: 71-79
• [Journal Article] Comparison of a Hydroxyapatite-Coated and an Anodic Oxidized Titanium Implant for Experimentally Induced Peri-Implantitis: Macroscopic and Novel Radiographic Evaluations in a Canine Model (2015)
  • Author(s): Nakamura, H., Matsuno, T., Hashimoto, Y., Nakamura, T., Mataga, I.
  • Journal Title: Journal of Hard Tissue Biology Volume: 24 Issue: 4 Pages: 347-356
  • DOI: 10.2485/jhtb.24.347
  • NAID: 130005104335
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Open Access
• [Presentation] 末梢神経の再生医療とin situ Tissue Engineering（生体内再生）． (2015)
  • Author(s): 中村達雄
  • Organizer: 第37回日本バイオマテリアル学会大会
  • Place of Presentation: 京都
  • Year and Date: 2015-10-09
• [Presentation] Verify the effect on nerve regeneration from increased blood flow in the nerve control area due to stellate ganglion blocks. (2014)
  • Author(s): Shigeno, K., Shionoya, Y., Kaneko, M., Wakatsuki, M., Nakada, A., Honda, M., Kojima, F., Sato, T., Inada, Y., Kanemaru, S., Nakamura, T.
  • Organizer: 41th Annual ESAO Congress
  • Place of Presentation: Roma
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] Bone repairing in the canine frontal sinus implanted octacalcium phosphate and collagen composite (II). (2014)
  • Author(s): Kaneko, M., Wakatsuki, M., Shigeno, K., Nakada, A., Nakamura, T.
  • Organizer: 41th Annual ESAO Congress
  • Place of Presentation: Roma
  • Year and Date: 2014-09-17 – 2014-09-20
• [Book] 複合性局所疼痛症候群(CRP)をもっと知ろうー病態・診断・治療から後遺障害診断まで― (2015)
  • Author(s): 稲田有史、諸井慶七朗、中村達雄、森本 茂
  • Total Pages: 129
  • Publisher: 株式会社 全日本病院出版会
• [Book] 臨床に役立つ神経障害性痛の理解 (2015)
  • Author(s): 稲田有史、中村達雄
  • Total Pages: 300
  • Publisher: 株式会社 文光堂
• [Remarks] 京都大学再生医科学研究所 臓器再建応用分野 ホームページ
  • URL: http://www.frontier.kyoto-u.ac.jp/ca04/
• [Remarks] 京都大学再生医科学研究所 臓器再建応用分野ホームページ
  • URL: http://www.frontier.kyoto-u.ac.jp/ca04/