Regeneration study of maxillofacial nerve using of artificial nerve tube with self mononuclear leukocyte (BMC) derived from bone marrow.
Project/Area Number |
26670864
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Kyoto University |
Principal Investigator |
Shigeno Keiji 京都大学, 再生医科学研究所, その他 (00162587)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA TATSUO 京都大学, 再生医科学研究所, 准教授 (70227908)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 人工神経管 / PGA-コラーゲンチューブ / 骨髄由来単核球(BMC) / 再生痛 / 神経再生実験 / 神経再生の質 / PGAコラーゲンチューブ / 神経再生 / 難治性神経因性疼痛 / 自己骨髄由来単核球 / 知覚神経 / 運動神経 / 混合神経 / 骨髄由来単核球 / 治癒促進能力 |
Outline of Final Research Achievements |
We were able to confirm that the trigeminal nerve which controlled difficulty and the maxillofacial which had been done, the exercise of maxillofacial and perception corresponded, and regeneration could provide improvement of speed of the nerve regeneration and the quality until now by gathering mononuclear leukocyte (BMC) derived from dog marrow than a host in this study, and using it for nerve damage region with an artificial neural tube (P.G.A. collagen tube) which We developed in a laboratory. In addition, We were able to confirm that We restrained "a pain - regeneration pain” to develop in the case of neurologic regeneration healing by this experiment as much as possible and bring about prompt nerve regeneration.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] The efficacy of a novel collagen-gelatin scaffold with basic fibroblast growth factor for the treatment of vocal fold scar.2016
Author(s)
Hiwatashi, N., Hirano, S., Mizuta, M., Kobayashi, T., Kawai, Y., Kanemaru, SI., Nakamura, T., Ito, J., Kawai, K., Suzuki, S.
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Journal Title
J Tissue Eng Regen Med.
Volume: in press
Issue: 5
Pages: 0-0
DOI
Related Report
Peer Reviewed
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[Journal Article] A rigid and bioabsorbble material for anterior chest wall reconstruction in a canine model.2015
Author(s)
Hamaji, M., Kojima, F., Koyasu, S., Nobashi, T., Tsuruyama, T., Date, H., Nakamura, T.
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Journal Title
Interact Cardiovasc Thorac Surg.
Volume: 20
Issue: 3
Pages: 322-328
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Autologous bone marrow mononuclear cell transplant and surgical decompression in a dog with chronic spinal cord injury.2015
Author(s)
Tamura, K., Harada, Y., Kunimi, M., Takemitsu, H., Hara, Y., Nakamura, T., Tagawa, M.
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Journal Title
Exp Clin Transplant.
Volume: 13
Pages: 100-5
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mechanical properties of a bioabsorbable nerve guide tube for long nerve defects.2015
Author(s)
Ichihara, S., Facca, S., Liverneaux, P., Inada, Y., Takigawa, T., Kaneko, K., Nakamura, T.
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Journal Title
Chir Main.
Volume: 34
Issue: 4
Pages: 186-192
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Comparison of a Hydroxyapatite-Coated and an Anodic Oxidized Titanium Implant for Experimentally Induced Peri-Implantitis: Macroscopic and Novel Radiographic Evaluations in a Canine Model2015
Author(s)
Nakamura, H., Matsuno, T., Hashimoto, Y., Nakamura, T., Mataga, I.
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Journal Title
Journal of Hard Tissue Biology
Volume: 24
Issue: 4
Pages: 347-356
DOI
NAID
ISSN
1341-7649, 1880-828X
Related Report
Peer Reviewed / Open Access
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[Presentation] Verify the effect on nerve regeneration from increased blood flow in the nerve control area due to stellate ganglion blocks.2014
Author(s)
Shigeno, K., Shionoya, Y., Kaneko, M., Wakatsuki, M., Nakada, A., Honda, M., Kojima, F., Sato, T., Inada, Y., Kanemaru, S., Nakamura, T.
Organizer
41th Annual ESAO Congress
Place of Presentation
Roma
Year and Date
2014-09-17 – 2014-09-20
Related Report
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