Epigenetic analysis of oral cancer stem cells involved in cancer recurrence

Research Project

Project/Area Number	26670873
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Surgical dentistry
Research Institution	Yokohama City University
Principal Investigator	KIOI Mitomu 横浜市立大学, 医学部, 准教授 (30545059)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	口腔癌 / 微小環境 / 難治性癌 / 癌再発
Outline of Final Research Achievements	To determine the initial signaling from the cancer stem cells for the recurrence, we implanted the cancer tissues obtained by biopsy or surgery from the patient with oral cancer into immunodeficient NOG mice (NOD.Cg-Prkdcscid 112rgtmlSug/Jic). The grown secondary tumors were implanted into either normal or pre-irradiated site. We found activation of HIF-1 in pre-irradiated site and analyzed the gene expression profile in tumors implanted in normal or pre-irradiated site.

Report

(3 results)