| Project/Area Number |
26670875
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
KATO Koichiro 金沢医科大学, 医学部, 助教 (30719373)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Yoshimichi 金沢医科大学, 医学部, 教授 (50271375)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAZAKI Toshiro 金沢医科大学, 医学部, 教授 (40233308)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔扁平上皮癌 / 浸潤性増殖 |
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| Outline of Final Research Achievements |
Sphingosin kinase 1 is expressed in the invading squamous cell carcinoma (SCC) cells of the oral cavity. Expression of sphingosin kinase 1 is not related to the differentiation of the tumor cells. Sphingosin kinase 1 is not associated with proliferative activity of SCC of the oral cavity but epithelial-mesenchymal transition (EMT) of SCC cells. It is suggested that Grade 3 and 4C SCC cells require tumor cell-host cell interaction to upregulate SK1, and Grade 4D cells are not dependent on the interaction but able to upregulate SK1 by themselves and exhibit vigorous invading capability.
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