| Project/Area Number |
26671004
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gerontological nursing
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Nakagami Gojiro 東京大学, 医学(系)研究科(研究院), 講師 (70547827)
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| Co-Investigator(Kenkyū-buntansha) |
Sanada Hiromi 東京大学, 大学院医学系研究科, 教授 (50143920)
峰松 健夫 東京大学, 医学(系)研究科(研究院), 講師 (00398752)
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| Co-Investigator(Renkei-kenkyūsha) |
Minematsu Takeo 東京大学, 大学院医学系研究科, 特任講師 (00398752)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | クオラムセンシング / 創傷治癒 / 高齢者 / 糖尿病 / 緑膿菌 / 感染 / 褥瘡 / 動物実験 / クオラオムセンシング |
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| Outline of Final Research Achievements |
Elderly people are suffering from intractable wounds due to the lack of proper wound healing. We aimed to develop a novel therapeutic method using quorum sensing signal (AHL). AHL topical application to the full-thickness wounds in diabetic rats showed inhibited inflammatory cell infiltration, enhanced proliferation of fibroblasts, and reduced oxidative stress. Furthermore, experiments using different length of acyl-acid of AHL revealed the C10-AHL promoted wound healing via neovascularization without inducing inflammation.
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