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Development of effective wound care management methods for promoting wounds among older people focusing on acylated homoserine lactone.

Research Project

Project/Area Number 26671004
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gerontological nursing
Research InstitutionThe University of Tokyo

Principal Investigator

Nakagami Gojiro  東京大学, 医学(系)研究科(研究院), 講師 (70547827)

Co-Investigator(Kenkyū-buntansha) Sanada Hiromi  東京大学, 大学院医学系研究科, 教授 (50143920)
峰松 健夫  東京大学, 医学(系)研究科(研究院), 講師 (00398752)
Co-Investigator(Renkei-kenkyūsha) Minematsu Takeo  東京大学, 大学院医学系研究科, 特任講師 (00398752)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsクオラムセンシング / 創傷治癒 / 高齢者 / 糖尿病 / 緑膿菌 / 感染 / 褥瘡 / 動物実験 / クオラオムセンシング
Outline of Final Research Achievements

Elderly people are suffering from intractable wounds due to the lack of proper wound healing. We aimed to develop a novel therapeutic method using quorum sensing signal (AHL). AHL topical application to the full-thickness wounds in diabetic rats showed inhibited inflammatory cell infiltration, enhanced proliferation of fibroblasts, and reduced oxidative stress. Furthermore, experiments using different length of acyl-acid of AHL revealed the C10-AHL promoted wound healing via neovascularization without inducing inflammation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 Other

All Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Presentation] 糖尿病モデルラット皮膚全層欠損創に対してアシル鎖長の異なるアシルホモセリンラクトンが及ぼす影響.2015

    • Author(s)
      後藤大地,仲上豪二朗,金澤寿樹,峰松健夫,真田弘美.
    • Organizer
      第45回日本創傷治癒学会
    • Place of Presentation
      JPタワー ホール&カンファレンス(東京都千代田区)
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Different effects of various N-acyl-homoserine lactones on healing process of full-thickness wounds in diabetic rats.2015

    • Author(s)
      Goto T, Nakagami G, Rajendran NK, Minematsu T, Sanada H.
    • Organizer
      2015 Global Prospect and New Innovations for Best Wound Care and Scar Management
    • Place of Presentation
      Kaohsiung Chang Gung Memorial Hospital(台湾、高雄市)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] N-(3-oxododecanoyl)-1-homoserine lactone promotes wound healing through the up regulation of HOMX1 and inhibits oxidative stress in diabetic rats.2014

    • Author(s)
      Naresh K, Minematsu T, Nishijima Y, Nakagami G, Sanada H.
    • Organizer
      第23回日本創傷・オストミー・失禁管理学会学術集会
    • Place of Presentation
      大宮ソニックシティ(埼玉県大宮市)
    • Year and Date
      2014-05-16 – 2015-05-17
    • Related Report
      2014 Research-status Report
  • [Remarks] 東京大学大学院医学系研究科 老年看護学/創傷看護学分野

    • URL

      http://www.rounenkango.m.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科健康科学・看護学専攻老年看護学/創傷看護学分野

    • URL

      http://www.rounenkango.m.u-tokyo.ac.jp/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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