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Molecular release for tissue engineering based on ultrafast Mie scattered light

Research Project

Project/Area Number 26702019
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Medical systems
Research InstitutionKeio University

Principal Investigator

Terakawa Mitsuhiro  慶應義塾大学, 理工学部(矢上), 准教授 (60580090)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsフェムト秒レーザー / ドラッグデリバリー / 生分解性ポリマー / レーザー医工学 / レーザー医療
Outline of Final Research Achievements

Stimuli-responsible controlled release of molecules was investigated by using near-infrared light toward the realization of efficient scaffold in tissue engineering. The method investigated was based on the ultrafast phenomena of intense Mie scattered light. Fabrication of guest-molecule-embedded capsules, experimental demonstration of femtosecond laser pulse-triggered molecular release, investigation on biodegradability of the polymers, fabrication of 3D structures as well as demonstration of molecular release were carried out. In summary, demonstration of molecular release via multi-photon process of near-infrared light was achieved.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (41 results)

All 2018 2017 2016 2015 2014

All Journal Article (12 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 9 results) Presentation (29 results) (of which Int'l Joint Research: 13 results,  Invited: 8 results)

  • [Journal Article] Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in hydrogel2018

    • Author(s)
      Umemoto Taiga、Terakawa Mitsuhiro
    • Journal Title

      Proceedings of SPIE

      Volume: 10522 Pages: 2-2

    • DOI

      10.1117/12.2287651

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Biodegradability of poly(lactic-co-glycolic acid) and poly(l-lactic acid) after deep-ultraviolet femtosecond and nanosecond laser irradiation2017

    • Author(s)
      Shibata Akimichi、Machida Manan、Kondo Naonari、Terakawa Mitsuhiro
    • Journal Title

      Applied Physics A

      Volume: 123 Issue: 6

    • DOI

      10.1007/s00339-017-1055-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオ・ソフトマテリアルのフェムト秒レーザー加工2017

    • Author(s)
      寺川光洋
    • Journal Title

      OPTRONICS

      Volume: 36 Pages: 149-153

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Femtosecond laser irradiation of the fluorescent molecules-loaded poly(lactic-co-glycolic acid)2017

    • Author(s)
      Taiga Umemoto, Akimichi Shibata, Mitsuhiro Terakawa
    • Journal Title

      Applied Surface Science

      Volume: 印刷中 Pages: 165-169

    • DOI

      10.1016/j.apsusc.2017.02.145

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acceleration of biodegradation by ultraviolet femtosecond laser irradiation to biodegradable polymer2017

    • Author(s)
      Akimichi Shibata, Shuhei Yada, Naonari Kondo, Mitsuhiro Terakawa
    • Journal Title

      Proc. SPIE

      Volume: 10094 Pages: 100941T-100941T

    • DOI

      10.1117/12.2250028

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation2016

    • Author(s)
      Akimichi Shibata, Shuhei Yada, Mitsuhiro Terakawa
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1

    • DOI

      10.1038/srep27884

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Laser-triggered release of encapsulated molecules from polylactic-co-glycolic acid microcapsules2016

    • Author(s)
      Kazumasa Ariyasu, Atsuhiro Ishii, Taiga Umemoto, Mitsuhiro Terakawa
    • Journal Title

      Journal of Biomedical Optics

      Volume: 21 Issue: 8 Pages: 085003-085003

    • DOI

      10.1117/1.jbo.21.8.085003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Laser Surface Modification of Biodegradable Polymers and Biomedical Applications2015

    • Author(s)
      寺川光洋、矢田周平
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 135 Issue: 9 Pages: 1043-1048

    • DOI

      10.1541/ieejeiss.135.1043

    • NAID

      130005096944

    • ISSN
      0385-4221, 1348-8155
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Femtosecond laser induced periodic surface structure on poly-L-lactic acid2015

    • Author(s)
      Shuhei Yada, Mitsuhiro Terakawa
    • Journal Title

      Optics Express

      Volume: 23 Issue: 5 Pages: 5694-5703

    • DOI

      10.1364/oe.23.005694

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Optical and thermal properties in ultrafast laser surface nanostructuring on biodegradable polymer2015

    • Author(s)
      Shuhei Yada, Mitsuhiro Terakawa
    • Journal Title

      Proceedings of SPIE

      Volume: 9355 Pages: 935503-935503

    • DOI

      10.1117/12.2080483

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] フェムト秒レーザーを用いた生分解性ポリマーの微細加工2015

    • Author(s)
      寺川光洋
    • Journal Title

      O plus E

      Volume: 37 Pages: 115-118

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] フェムト秒レーザと微粒子を利用したドラッグデリバリー2014

    • Author(s)
      寺川光洋,三橋龍樹,有安和優
    • Journal Title

      レーザ加工学会誌

      Volume: 21 Pages: 24-29

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] 超短パルスレーザーによる生体材料の微細加工2018

    • Author(s)
      寺川光洋,柴田明道,近藤直柔,石井敦浩,Dag Heinemann
    • Organizer
      レーザー学会学術講演会第38回年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Femtosecond laser-triggered molecular release from biodegradable polymer microcapsules incorporated in hydrogel2018

    • Author(s)
      Taiga Umemoto, Mitsuhiro Terakawa
    • Organizer
      SPIE Photonics West 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フェムト秒レーザーを用いて微小貫通孔を作製した生分解性フィルムの細胞接着効果2018

    • Author(s)
      近藤直柔,角井泰之,佐藤俊一, 寺川光洋
    • Organizer
      レーザー学会学術講演会第38回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Acceleration of biodegradation by ultraviolet femtosecond laser irradiation to biodegradable polymer2017

    • Author(s)
      Akimichi Shibata, Shuhei Yada, Naonari Kondo, Mitsuhiro Terakawa
    • Organizer
      SPIE Photonics WEST 2017
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2017-01-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Subtractive and additive processing of biocompatible materials using femtosecond laser2017

    • Author(s)
      Mitsuhiro Terakawa, Akimichi Shibata, Manan Machida, Yasutaka Nakajima
    • Organizer
      The 25th International Conference on Advanced Laser Technologies (ALT’17)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ultrafast laser processing of biomaterials2017

    • Author(s)
      Mitsuhiro Terakawa
    • Organizer
      European Materials Research Society (E-MRS) Spring Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] フェムト秒レーザー照射による多孔生分解性ポリマーフィルムの作製2017

    • Author(s)
      近藤直柔、角井泰之、佐藤俊一、寺川光洋
    • Organizer
      第38回日本レーザー医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生分解性ポリマーカプセル含有ハイドロゲルへのフェムト秒レーザー照射による分子放出2017

    • Author(s)
      梅本大河、寺川光洋
    • Organizer
      第38回日本レーザー医学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Subtractive and additive processing of biomaterials using femtosecond laser2016

    • Author(s)
      Mitsuhiro Terakawa
    • Organizer
      International Congress on Applications on Lasers & Electro-Optics (ICALEO) 2016
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-10-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Femtosecond laser-based subtractive and additive processing for bioapplications2016

    • Author(s)
      Mitsuhiro Terakawa, Akimichi Shibata, Shuhei Yada, Manan Machida, Maria Leilani Torres-Mapa, Dag Heinemann, Alexander Heisterkamp
    • Organizer
      第77回応用物理学会秋季学術講演会JSAP-OSA Joint Symposia
    • Place of Presentation
      朱鷺メッセ(新潟県・新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Femtosecond laser irradiation to fluorescent molecules-loaded poly(lactic-co-glycolic acid)2016

    • Author(s)
      Taiga Umemoto, Akimichi Shibata, Mitsuhiro Terakawa
    • Organizer
      10th International Conference on Photo-Excited Processes and Applications (ICPEPA10)
    • Place of Presentation
      Brasov (Romania)
    • Year and Date
      2016-08-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Femtosecond laser processing of poly(lactic-co-glycolic acid) at 800, 400, and 266 nm wavelengths2016

    • Author(s)
      Akimichi Shibata, Shuhei Yada, Mitsuhiro Terakawa
    • Organizer
      The Second Smart Laser Processing Conference (SLPC) 2016
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wettability modification of poly (lactic-co-glycolic acid) (PLGA) film by femtosecond laser irradiation2016

    • Author(s)
      Sachie Yukawa, Akimichi. Shibata, Syuhei Yada, Mitsuhiro Terakawa
    • Organizer
      European Materials Research Society (E-MRS) Spring Meeting 2016
    • Place of Presentation
      Lille (France)
    • Year and Date
      2016-05-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フェムト秒レーザー照射による乳酸・グリコール酸共重合体からの蛍光分子放出2016

    • Author(s)
      梅本大河、柴田明道、矢田周平、有安和優、寺川光洋
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京工業大学大岡山キャンパス(東京都・目黒区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 配列生分解性ポリマーカプセルへのフェムト秒レーザー照射による内包蛍光分子放出2016

    • Author(s)
      花谷直紀、石井敦浩、有安和優、矢田周平、寺川光洋
    • Organizer
      第16回レーザー学会東京支部研究会
    • Place of Presentation
      東海大学高輪キャンパス(東京都・港区)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] Femtosecond laser-triggered rupture of biodegradable polymer capsules containing fluorescent molecules2016

    • Author(s)
      Kazumasa Ariyasu, Mitsuhiro Terakawa
    • Organizer
      SPIE Photonics West 2016
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2016-02-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超短パルスレーザによるPLGAカプセル内包分子の放出2015

    • Author(s)
      有安和優、寺川光洋
    • Organizer
      医用光学・分光学系合同研究会
    • Place of Presentation
      ホテルグランドヒル市ヶ谷(東京都・新宿区)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 薬剤放出制御に向けた生分解性マイクロカプセルへのフェムト秒レーザー照射2015

    • Author(s)
      有安和優、寺川光洋
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳酸・グリコール酸共重合体のフェムト秒レーザーアブレーション:生分解性変化の照射波長依存性2015

    • Author(s)
      柴田明道、矢田周平、寺川光洋
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Nanostructure Formation on PLLA and PLGA by Femtosecond Laser Irradiation2015

    • Author(s)
      Shuhei Yada, Akimichi Shibata, Sachie Yukawa, Mitsuhiro Terakawa
    • Organizer
      The 13th Conference on Laser Ablation
    • Place of Presentation
      Cairns(Australia)
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modification of biodegradability of poly(lactic-co-glycolic acid) by femtosecond laser irradiation2015

    • Author(s)
      A. Shibata, S. Yada, M. Terakawa
    • Organizer
      The 13th Conference on Laser Ablation
    • Place of Presentation
      Cairns(Australia)
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultrafast laser-induced scattered far-field for fabrication of nanostructures2015

    • Author(s)
      Mitsuhiro Terakawa, Yasutaka Nakajima, Akihiro Takami, Shuhei Yada, Akimichi Shibata, Nikolay Nedyalkov
    • Organizer
      17th Inernational Conference on Transparent Optical Networks
    • Place of Presentation
      Budapest(Hungary)
    • Year and Date
      2015-07-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Femtosecond laser surface nanoprocessing of biodegradable polymers2015

    • Author(s)
      Mitsuhiro Terakawa, Shuhei Yada, Akimichi Shibata
    • Organizer
      European Materials Research Society, Spring Meeting 2015
    • Place of Presentation
      Lille(France)
    • Year and Date
      2015-05-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] フェムト秒レーザ照射による生分解性ポリマーのアブレーションと生分解性変化2015

    • Author(s)
      矢田周平,柴田明道,寺川光洋
    • Organizer
      電気学会 光・量子デバイス研究会
    • Place of Presentation
      弘前大学(青森県弘前市)
    • Year and Date
      2015-03-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] フェムト秒レーザー照射による乳酸・グリコール酸共重合体の分解速度変化2015

    • Author(s)
      柴田明道,矢田周平,寺川光洋
    • Organizer
      第15回レーザー学会東京支部研究会
    • Place of Presentation
      東海大学高輪キャンパス(東京都港区)
    • Year and Date
      2015-03-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] フェムト秒レーザー照射による生分解性ポリマーカプセルの表面形状変化2015

    • Author(s)
      有安和優,寺川光洋
    • Organizer
      第15回レーザー学会東京支部研究会
    • Place of Presentation
      東海大学高輪キャンパス(東京都港区)
    • Year and Date
      2015-03-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Optical and thermal properties in ultrafast laser surface nanostructuring on biodegradable polymer2015

    • Author(s)
      Shuhei Yada, Mitsuhiro Terakawa
    • Organizer
      SPIE Photonics West 2015
    • Place of Presentation
      サンフランシスコ(アメリカ合衆国)
    • Year and Date
      2015-02-07 – 2015-02-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Femtosecond laser nanoablation of biodegradable polymer2014

    • Author(s)
      Mitsuhiro Terakawa
    • Organizer
      Advanced Laser Technologies ‘14
    • Place of Presentation
      カシ(フランス)
    • Year and Date
      2014-10-06 – 2014-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Disruption of PLGA microcapsules by femtosecond laser irradiation2014

    • Author(s)
      Kazumasa Ariyasu, Mitsuhiro Terakawa
    • Organizer
      9th International Conference on Photo Excited Processes and Applications (ICPEPA-9)
    • Place of Presentation
      くにびきメッセ(島根県松江市)
    • Year and Date
      2014-09-29 – 2014-10-03
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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