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Manipulation of blood lactate concentration against obesity

Research Project

Project/Area Number 26702029
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Sports science
Research InstitutionRitsumeikan University

Principal Investigator

Hashimoto Takeshi  立命館大学, スポーツ健康科学部, 教授 (70511608)

Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords代謝疾患 / 運動 / サプリメント / 加齢 / 筋肥大 / サルコペニア / 糖代謝 / 肥満 / 乳酸 / 脂肪燃焼 / 抗肥満 / 自発性運動 / 低酸素 / 血糖値 / 皮下脂肪 / 低強度運動 / 内臓脂肪 / 栄養学 / 細胞・組織 / 骨格筋 / 脂質 / MRI / 筋萎縮 / 持久性運動
Outline of Final Research Achievements

I have been focusing on the lactate metabolism, and found that it functions as an inducer of cell signaling in skeletal muscle cells (e.g., increased mitochondrial biogenesis and myogenesis) and adipocytes (e.g., increased lipases expression). The aim of this study was to examine whether manipulation of blood lactate concentration can be a therapeutic strategy against obesity and metabolic disorder by reducing fat mass and preventing muscle atrophy. I found that the supplementation of lactate-based compound elicits muscle hypertrophy, reduces fat mass, and improves glucose metabolism. These findings suggest that lactate may be a beneficial molecule against obesity and metabolic disorder.

Academic Significance and Societal Importance of the Research Achievements

健康増進に対する運動効果は周知の事実であるが、そのメカニズムは多面的である。その中で、運動(特に高強度の運動)誘発性の乳酸が運動効果の分子機序の一つとして機能し得ることを、細胞、動物、ヒトを対象とした多角的な実験的検証から明らかにした。このことは、特に乳酸産生を促すような運動の有用性を示唆するとともに、サプリメントなど、外的に乳酸を付加することの有用性も示唆しており、広く万人に有効な肥満と代謝疾患の予防・改善に繋がる知見を提供し得た。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (59 results)

All 2019 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (20 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 20 results,  Open Access: 10 results,  Acknowledgement Compliant: 4 results) Presentation (29 results) (of which Int'l Joint Research: 15 results,  Invited: 4 results) Book (5 results) Remarks (2 results)

  • [Int'l Joint Research] コペンハーゲン大学(デンマーク)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 建国大学(韓国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Department of Physical Education/Korea University(韓国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A Lactate-based compound containing caffeine in addition to voluntary running exercise decreases subcutaneous fat mass and improves glucose metabolism in obese rats2019

    • Author(s)
      Hashimoto T, Yokokawa T, Narusawa R, Okada Y, Kawaguchi R, Higashida K
    • Journal Title

      Journal of Functional Foods

      Volume: 56 Pages: 84-91

    • DOI

      10.1016/j.jff.2019.03.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise.2019

    • Author(s)
      Tsukamoto H, Hashimoto T, Olesen ND, Petersen LG, Sorensen H, Nielsen HB, Secher NH, Ogoh S.
    • Journal Title

      Med Sci Sports Exerc.

      Volume: Feb;51(2) Issue: 2 Pages: 372-378

    • DOI

      10.1249/mss.0000000000001792

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self-selected music-induced reduction of perceived exertion during moderate-intensity exercise does not interfere with post-exercise improvements in inhibitory control2018

    • Author(s)
      Tanaka D, Tsukamoto H, Suga T, Takenaka S, Hamaoka T, Hashimoto T, Isaka T
    • Journal Title

      Physiology and Behavior

      Volume: 194 Pages: 170-176

    • DOI

      10.1016/j.physbeh.2018.05.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice.2018

    • Author(s)
      Horii N, Uchida M, Hasegawa N, Fujie S, Oyanagi E, Yano H, Hashimoto T, Iemitsu M.
    • Journal Title

      FASEB J

      Volume: - Issue: 7 Pages: 3547-3559

    • DOI

      10.1096/fj.201700772rrr

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men2018

    • Author(s)
      Hashimoto T, Tsukamoto H, Takenaka S, Olesen N.D., Petersen L.G., Sorensen H, Nielsen H.B., Secher N.H., Ogoh S
    • Journal Title

      FASEB Journal

      Volume: 32 Issue: 3 Pages: 1417-1427

    • DOI

      10.1096/fj.201700381rr

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Flavanol-rich cocoa consumption enhances exercise-induced executive function improvements in humans2018

    • Author(s)
      Tsukamoto H, Suga T, Ishibashi A, Takenaka S, Tanaka D, Hirano Y, Hamaoka T, Goto K, Ebi K, Isaka T, and Hashimoto T
    • Journal Title

      Nutrition

      Volume: 46 Pages: 90-96

    • DOI

      10.1016/j.nut.2017.08.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An acute bout of localized resistance exercise can rapidly improve inhibitory control2017

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Takeuchi T, Tanaka D, Hamaoka T, Hashimoto T, and Isaka T
    • Journal Title

      PLoS One

      Volume: 12 Issue: 9 Pages: e0184075-e0184075

    • DOI

      10.1371/journal.pone.0184075

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of exercise intensity and duration on postexercise executive function.2017

    • Author(s)
      Hayato Tsukamoto, Saki Takenaka, Tadashi Suga, Daichi Tanaka, Tatsuya Takeuchi, Takafumi Hamaoka, Tadao Isaka, Takeshi Hashimoto
    • Journal Title

      Medicine & Science in Sports & Exercise.

      Volume: 49(4) Issue: 4 Pages: 774-784

    • DOI

      10.1249/mss.0000000000001155

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Intracellular oxygen tension limits muscle contraction- induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion.2017

    • Author(s)
      214.Takakura H, Ojino M, Jue T, Yamada T, Furuichi Y, Hashimoto T, Iwase S, Masuda K:
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 2 Pages: 1-10

    • DOI

      10.14814/phy2.13112

    • NAID

      120006226796

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spaceflight and Biohistochemical Alterations of Antigravity Soleus Muscle in Spontaneously Hypertensive Rats (SHR) to Dietary Low- and High- Calcium Intake2016

    • Author(s)
      Taguchi S, Ogoh S, Hashimoto T, Yamasaki S, Okamoto H, Yamori Y, Hatton DC and McCarron DA
    • Journal Title

      Journal of Bioanalysis & Biomedicine

      Volume: 8 Issue: 3 Pages: 41-47

    • DOI

      10.4172/1948-593x.1000151

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protective and therapeutic effects of fucoxanthin against sunburn caused by UV irradiation2016

    • Author(s)
      Matsui M, Tanaka K, Higashiguchi N, Okawa H, Yamada Y, Tanaka K, Taira S, Aoyama T, Takanishi M, Natsume C, Takakura Y, Fujita N, Hashimoto T, Fujita T
    • Journal Title

      Journal of Pharmacological Science

      Volume: 132 Issue: 1 Pages: 55-64

    • DOI

      10.1016/j.jphs.2016.08.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carotid baroreflex function at the onset of cycling in men.2016

    • Author(s)
      Barbosa TC, Vianna LC, Hashimoto T, Petersen LG, Olesen ND, Tsukamoto H, Sorensen H, Ogoh S, Nebrega AC, Secher NH.
    • Journal Title

      American Journal of Physiology

      Volume: 311(5) Issue: 5 Pages: 870-878

    • DOI

      10.1152/ajpregu.00173.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High-intensity intermittent exercise training with chlorella intake accelerates exercise performance and muscle glycolytic and oxidative capacity in rats2016

    • Author(s)
      Horii N, Hasegawa N, Fujie S, Uchida M, Miyamoto-Mikami E, Hashimoto T, Tabata I, Iemitsu M.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 312 Issue: 4 Pages: 520-528

    • DOI

      10.1152/ajpregu.00383.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myoglobin and the Regulation of Mitochondrial Respiratory Chain Complex IV2016

    • Author(s)
      Yamada T, Takakura H, Jue T, Hashimoto T, Ishizawa R, Furuichi Y, Kato Y, Iwanaka N, Masuda K
    • Journal Title

      The Journal of Physiology

      Volume: 594 Issue: 2 Pages: 483-495

    • DOI

      10.1113/jp270824

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Greater impact of acute high-intensity interval exercise on post-exercise executive function compared to moderate-intensity continuous exercise2016

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, and Hashimoto T
    • Journal Title

      Physiology and Behavior

      Volume: 155 Pages: 224-230

    • DOI

      10.1016/j.physbeh.2015.12.021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Repeated high-intensity interval exercise shortens the positive effect on executive function during post-exercise recovery in healthy young males2016

    • Author(s)
      Tsukamoto H, Suga T, Takenaka S, Tanaka D, Takeuchi T, Hamaoka T, Isaka T, Ogoh S, and Hashimoto T
    • Journal Title

      Physiology and Behavior

      Volume: 160 Pages: 26-34

    • DOI

      10.1016/j.physbeh.2016.03.029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle.2015

    • Author(s)
      Takakura H., Furuichi Y., Yamada T., Jue T., Ojino M., Hashimoto T., Iwase S., Hojo T., Izawa T. and Masuda K
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 9403-9403

    • DOI

      10.1038/srep09403

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1α expression in C2C12 myotubes2015

    • Author(s)
      Yokokawa T, Sato K, Iwanaka N, Honda H, Higashida K, Iemitsu M, Hayashi T, Hashimoto T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 463 Pages: 42-47

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Specific characterization of regional storage fat in upper and lower limbs of young healthy adults2015

    • Author(s)
      Junichiro Yamauchi, Toshiyuki Kurihara, Maki Yoshikawa, Sadayoshi Taguchi, Takeshi Hashimoto
    • Journal Title

      Springer Plus

      Volume: 4 Issue: 1 Pages: 402-402

    • DOI

      10.1186/s40064-015-1181-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mixed lactate and caffeine compound increases satellite cell activity and anabolic signals for muscle hypertrophy.2015

    • Author(s)
      Oishi Y, Tsukamoto H, Yokokawa T, Hirotsu K, Shimazu M, Uchida K, Tomi H, Higashida K, Iwanaka N, Hashimoto T.
    • Journal Title

      Journal of Applied Physiology

      Volume: 118 Issue: 6 Pages: 742-9

    • DOI

      10.1152/japplphysiol.00054.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of low-volume high-intensity interval exercise on post-exercise inhibitory control2019

    • Author(s)
      Sugimoto T, Suga T, Tsukamoto H, Tanaka D, Takenaka S, Shimoho K, Isaka T, Hashimoto T
    • Organizer
      The 9th FAOPS Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of exercise and brain metabolism on cognitive executive function in human2018

    • Author(s)
      Hashimoto T
    • Organizer
      The 30th International Sport Science Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 間欠的運動が運動誘発性の実行機能改善に及ぼす効果2018

    • Author(s)
      杉本岳史, 菅唯志, 塚本敏人, 伊坂忠夫, 橋本健志
    • Organizer
      第31回日本トレーニング科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Plasma oxytocin level is enhanced by acute high-intensity interval exercise in men2018

    • Author(s)
      Tsukamoto H, Olesen ND, Petersen LG, Suga T, Sorensen H, Nielsen HB, Ogoh S, Secher NH, Hashimoto T
    • Organizer
      Europhysiology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 栄養介入の分子作用機序解明と抗サルコペニアへの応用2018

    • Author(s)
      橋本健志
    • Organizer
      日本スポーツ栄養学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Acute effect of resistance exercise and substantial breakfast on muscle breakdown in healthy young men2018

    • Author(s)
      Kume W, Yoshikawa M, Yasuda J, Hashimoto T
    • Organizer
      European College of Sport Science 23th Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic cerebral autoregulation is not impaired during high-intensity interval exercise2018

    • Author(s)
      Tsukamoto H, Hashimoto T, Olesen ND, Petersen LG, Sorensen H, Nielsen HB, Secher NH, Ogoh S
    • Organizer
      European College of Sport Science 23th Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ameliorative effect of Fucoxanthin on decreased skeletal muscle mass in mice2018

    • Author(s)
      Yoshikawa M, Sakushima K, Kume W, Usami K, Hosokawa M, Miyashita K, Nishino H, Hashimoto T
    • Organizer
      European College of Sport Science 23th Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Hypoxia promotes skeletal muscle differentiation in C2C12 skeletal muscle cells2018

    • Author(s)
      Sakushima K, Yoshikawa M, Hashimoto T
    • Organizer
      European College of Sport Science 23th Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of hypoxia on skeletal muscle characteristic2017

    • Author(s)
      Hashimoto T, Osaki T
    • Organizer
      The 94th Annual meeting of the Physiological Society of Japan
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県、浜松市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cerebral energy metabolism and executive function after repeated high-intensity interval exercise with decreased lactate concentration2017

    • Author(s)
      Tsukamoto H, Olesen N.D., Petersen L.G., Sorensen H, Nielsen H.B., Secher N.H., Ogoh S, Hashimoto T
    • Organizer
      American college of sports medicine's 64th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of changes in brain lactate uptake and BDNF production on executive function after high intensity interval exercise in humans2017

    • Author(s)
      Takenaka S, Tsukamoto H, Olesen N.D., Petersen L.G., Sorensen H, Nielsen H.B., Secher N.H., Ogoh S, Hashimoto T
    • Organizer
      28th Symposium on Cerebral Blood Flow, Metabolism and Function & 13th Conference on Quantification of Brain Function with PET
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship of brain lactate uptake, cerebral hemodynamics, and executive function after high intensity interval exercise in humans2017

    • Author(s)
      Tsukamoto H, Olesen N.D., Petersen L.G., Sorensen H, Nielsen H.B., Secher N.H., Ogoh S, Hashimoto T
    • Organizer
      28th Symposium on Cerebral Blood Flow, Metabolism and Function & 13th Conference on Quantification of Brain Function with PET
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lactate and Caffeine treatment can increase fat oxidation on resting metabolic rate in rats2016

    • Author(s)
      Kim J, Yoo C-S, Hashimoto T, Tomi H, Kawasaki M, Lim K
    • Organizer
      The 67th Annual meeting of Korean Society of Food Science and Nutrition
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Caffeine and Lactate mixture treatment on gene expressions related to energy metabolism in rat skeletal muscle2016

    • Author(s)
      Yoo C-S, Kim J, Hashimoto T, Tomi H, Kawasaki M, Teramoto N, Lim K
    • Organizer
      The 67th Annual meeting of Korean Society of Food Science and Nutrition
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of Fucoxanthinol on lipolytic activity in 3T3-L1 adipocytes2016

    • Author(s)
      Yoshikawa M, Fujita T, Hosokawa M, Miyashita K, Nishino H, and Hashimoto T
    • Organizer
      21th European College of Sport Science
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内における乳酸の役割2016

    • Author(s)
      橋本健志
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dehydroepiandrosterone activates 5’-adenosine monophosphate-activated protein kinase and suppresses adipogenesis in 3T3-L1 cells2015

    • Author(s)
      Yokokawa T, Sato K, Narusawa R, Kido K, Mori R, Iwanaka N, Hayashi T, Hashimoto T
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸ポートアイランド、兵庫県・神戸市
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lactate-based compound containing caffeine supplementation effectively decreases fat mass in middle-aged Japanese women2015

    • Author(s)
      Hashimoto T, Kurihara T, Homma T, Yoshikawa M, Narusawa R, Shimazu M, Uchida K, Kawasaki M, Tomi H, Hamaoka T
    • Organizer
      Obesityweek 2015
    • Place of Presentation
      Los Angels, USA
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳酸主体の飲用物が脂肪分解関連タンパク質発現に及ぼす影響の解析2015

    • Author(s)
      成澤諒子、横川拓海、東田一彦、橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館、和歌山県・和歌山市
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] テオフィリンがC2C12骨格筋細胞における糖・脂質代謝関連遺伝子発現に及ぼす影響2015

    • Author(s)
      大崎智彦、横川拓海、木戸康平、岩中伸壮、橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館、和歌山県・和歌山市
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] C2C12骨格筋細胞において、カルシウムシグナルならびにAMP kinaseがPGC-1 related coactivatorの遺伝子発現に及ぼす影響の検討2015

    • Author(s)
      横川拓海、大崎智彦、岩中伸壮、林達也、橋本健志
    • Organizer
      日本体力医学会
    • Place of Presentation
      和歌山県民文化会館、和歌山県・和歌山市
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of lactoferrin on lipolytic activity upon catecholamine stimulation in 3T3-L1 adipocytes2015

    • Author(s)
      Sakamoto S, Ono T, Murakoshi M, and Hashimoto T
    • Organizer
      European College of Sport Science
    • Place of Presentation
      Malmo, Sweden
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経細胞においてp38 MAPKおよびcAMP シグナルはPGC-1 familyの発現を制御する2015

    • Author(s)
      横川拓海,守村直子,三品昌美,藤田隆司,田中秀和,林達也,橋本健志
    • Organizer
      日本生化学会近畿支部例会
    • Place of Presentation
      立命館大学、滋賀県・草津市
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Lactate-based compound containing caffeine effectively decreases fat mass with low intensity exercise training2014

    • Author(s)
      T. Hashimoto, T. Yokokawa, K. Higashida
    • Organizer
      ObesityWeek 2014
    • Place of Presentation
      Boston(USA)
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dehydroepiandrosterone activates 5’-adenosine monophosphate-activated protein kinase in L6 myotubes2014

    • Author(s)
      T. Yokokawa, K. Sato, N. Iwanaka, H. Honda, K. Higashida, T. Fujita, T. Hayahi, T. Hashimoto
    • Organizer
      日本生化学会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lactate-based compound containing caffeine effectively increases muscle mass in rats2014

    • Author(s)
      T. Hashimoto, Y. Oishi, T. Yokokawa, N. Iwanaka, H. Tsukamoto, K. Higashida
    • Organizer
      Integrative Physiology of Exercise
    • Place of Presentation
      Miami(USA)
    • Year and Date
      2014-09-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] The relationship between subcutaneous fat and intramuscular lipid in human limb2014

    • Author(s)
      M. Yoshikawa, T. Kurihara, S. Taguchi, J. Yamauchi, T. Hashimoto
    • Organizer
      19th European College of Sport Science
    • Place of Presentation
      Amsterdam(Netherlands)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Lactate-based supplement with caffeine effectively induces satellite cells activity and anabolic signals for muscle hypertrophy in rats2014

    • Author(s)
      T. Hashimoto, Y. Oishi, T. Yokokawa, H. Tsukamoto, N. Iwanaka, K. Higashida
    • Organizer
      61th American College of Sport Medicine
    • Place of Presentation
      Orland(USA)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Book] 体育の科学 『トレーニングと認知機能適応』2018

    • Author(s)
      橋本健志、小河繁彦
    • Total Pages
      7
    • Publisher
      杏林書院
    • Related Report
      2018 Annual Research Report
  • [Book] 運動の健康への効用について2016

    • Author(s)
      塚本敏人、橋本健志
    • Total Pages
      6
    • Publisher
      自動車技術
    • Related Report
      2016 Annual Research Report
  • [Book] アンチ・エイジング医学─日本抗加齢医学会雑誌 『運動によるミトコンドリア活性化:乳酸の役割』2015

    • Author(s)
      橋本健志
    • Total Pages
      9
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Book] ニュー運動生理学II2015

    • Author(s)
      橋本健志
    • Total Pages
      416
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2014 Annual Research Report
  • [Book] 進化する運動科学の研究最前線2014

    • Author(s)
      橋本健志、岩中伸壮
    • Total Pages
      440
    • Publisher
      NTS
    • Related Report
      2014 Annual Research Report
  • [Remarks] 立命館大学スポーツ健康科学部ニュース一覧

    • URL

      http://www.ritsumei.ac.jp/shs/news/article.html/?id=216

    • Related Report
      2015 Annual Research Report
  • [Remarks] 立命館大学スポーツ健康科学部ニュース一覧

    • URL

      http://www.ritsumei.ac.jp/shs/news/article.html/?id=193

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2022-02-16  

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