Elucidation of sleep-wake mechanism by controlling cell function
Project/Area Number |
26702037
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Basic / Social brain science
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Research Institution | Toho University (2016) Tokyo Metropolitan Institute of Medical Science (2014-2015) |
Principal Investigator |
UENO Taro 東邦大学, 理学部, 講師 (30648267)
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Co-Investigator(Renkei-kenkyūsha) |
FURUTA Toshiaki 東邦大学, 理学部, 教授 (90231571)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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Keywords | 睡眠 / ケミカルジェネティクス / 神経科学 / ケミカルバイオロジー |
Outline of Final Research Achievements |
Fluorescein-modified compounds were prepared and added to the transfected cells, and a marked fluorescence enhancement of fluorescein was observed in cells expressing PLE. We generated a transgenic fly expressing PLE only in specific cells in the expression-dependent manner of GAL4, and when the above compound was administered to the isolated brain, tissue-specific fluorescence was observed. In order to examine whether behavior control at an individual level is possible, Drosophila expressing PLE specifically for dopamine cells was created. A compound to which a modifying group was added to a dopamine synthase inhibitor was administered by oral administration, but no change in sleep awakening amount was observed.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Glial dysfunction causes age-related memory impairment in Drosophila.2014
Author(s)
Yamazaki D, Horiuchi J, Ueno K, Ueno T, Saeki S, Matsuno M, Naganos S, Miyashita T, Hirano Y, Nishikawa H, Taoka M, Yamauchi Y, Isobe T, Honda Y, Kodama T, Masuda T, Saitoe M
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Journal Title
Neuron
Volume: 84
Issue: 4
Pages: 753-763
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 児童・生徒の睡眠障害2015
Author(s)
上野太郎
Organizer
東京都北区学校保健会
Place of Presentation
滝野川会館(東京都・北区)
Year and Date
2015-05-14
Related Report
Invited
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[Presentation] 睡眠研究の最前線2015
Author(s)
上野太郎
Organizer
都民講座
Place of Presentation
東京都医学総合研究所(東京都・世田谷区)
Year and Date
2015-04-24
Related Report
Invited
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[Presentation] 睡眠研究の最前線2015
Author(s)
上野太郎
Organizer
東京都都民講座
Place of Presentation
東京都医学総合研究所(東京都・世田谷区)
Year and Date
2015-04-24
Related Report
Invited
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