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Development of cancer specific glycosylation subtype biomarkers

Research Project

Project/Area Number 26710007
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Tumor diagnostics
Research InstitutionJapanese Foundation for Cancer Research (2015-2017)
The University of Tokyo (2014)

Principal Investigator

Ueda Koji  公益財団法人がん研究会, がんプレシジョン医療研究センター がんオーダーメイド医療開発プロジェクト, プロジェクトリーダー (10509110)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords糖鎖 / バイオマーカー / 腫瘍マーカー / プロテオーム / 質量分析 / 癌 / がん / プロテオミクス
Outline of Final Research Achievements

To develop a specificity-enhanced tumor diagnostic system, we constructed a quantitative and sensitive glycan structure profiling technology based on mass spectrometry. Comprehensive glycoform analysis of 30 serum samples (15 benign prostate hyperplasia (BPH) and 15 prostate cancer, PSA = 4-10 ng/ml) revealed that, among 67 glycan structures, a couple of glycoforms on PSA had highly cancer-specific expressions patterns. Then we established a logistic regression-based diagnostics using expression frequencies of these structures (PSA G-index). Importantly, when we performed a blinded validation test using 15 BPH and 15 prostate cancer samples, PSA G-index allowed classification of all samples into correct clinical groups (sensitivity and specificity were 100%). Thus, PSA G-index could serve as a definitive secondary test for PSA test, leading to significant reduction of false positive diagnosis of prostate cancer.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (62 results)

All 2018 2017 2016 2015 2014

All Journal Article (19 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 19 results,  Open Access: 13 results,  Acknowledgement Compliant: 4 results) Presentation (36 results) (of which Int'l Joint Research: 11 results,  Invited: 27 results) Book (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility2018

    • Author(s)
      Tanikawa Chizu、Ueda Koji、Suzuki Akari、Iida Aritoshi、Nakamura Ryoichi、Atsuta Naoki、Tohnai Genki、Sobue Gen、Saichi Naomi、Momozawa Yukihide、Kamatani Yoichiro、Kubo Michiaki、Yamamoto Kazuhiko、Nakamura Yusuke、Matsuda Koichi
    • Journal Title

      Cell Reports

      Volume: 22 Issue: 6 Pages: 1473-1483

    • DOI

      10.1016/j.celrep.2018.01.031

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracellular vesicles isolated from human renal cell carcinoma tissues disrupt vascular endothelial cell morphology via azurocidin2017

    • Author(s)
      Jingushi Kentaro、Uemura Motohide、Ohnishi Naomi、Nakata Wataru、Fujita Kazutoshi、Naito Takuya、Fujii Risa、Saichi Naomi、Nonomura Norio、Tsujikawa Kazutake、Ueda Koji
    • Journal Title

      International Journal of Cancer

      Volume: 142 Issue: 3 Pages: 607-617

    • DOI

      10.1002/ijc.31080

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p53-independent p21 induction by MELK inhibition2017

    • Author(s)
      Matsuda Tatsuo、Kato Taigo、Kiyotani Kazuma、Tarhan Yunus Emre、Saloura Vassiliki、Chung Suyoun、Ueda Koji、Nakamura Yusuke、Park Jae-Hyun
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 35 Pages: 57938-57947

    • DOI

      10.18632/oncotarget.18488

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway2017

    • Author(s)
      Takahashi Yukie、Tanikawa Chizu、Miyamoto Takafumi、Hirata Makoto、Wang Guanxiong、Ueda Koji、Komatsu Tsunehiko、Matsuda Koichi
    • Journal Title

      International Journal of Oncology

      Volume: 51 Issue: 2 Pages: 724-736

    • DOI

      10.3892/ijo.2017.4060

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p532017

    • Author(s)
      Miyamoto Takafumi、Lo Paulisally Hau Yi、Saichi Naomi、Ueda Koji、Hirata Makoto、Tanikawa Chizu、Matsuda Koichi
    • Journal Title

      Science Advances

      Volume: 3 Issue: 5 Pages: 1603204-1603204

    • DOI

      10.1126/sciadv.1603204

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small cell lung cancer cells2017

    • Author(s)
      Wang, R., Deng, X., Yoshioka, Y., Vougiouklakis, T., Park, J. H., Suzuki, T., Dohmae, N., Ueda, K., Hamamoto, R. and Nakamura, Y.
    • Journal Title

      Cancer Science

      Volume: in press Issue: 6 Pages: 1203-1209

    • DOI

      10.1111/cas.13245

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] MiR-21-5p in urinary extracellular vesicles is a novel biomarker of urothelial carcinoma.2017

    • Author(s)
      Matsuzaki K et al.
    • Journal Title

      Oncotarget

      Volume: - Issue: 15 Pages: 14969-14969

    • DOI

      10.18632/oncotarget.14969

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis.2017

    • Author(s)
      Mori J, Tanikawa C, Ohnishi N, Funauchi Y, Toyoshima O, Ueda K, Matsuda K.
    • Journal Title

      Neoplasia

      Volume: 19 Issue: 3 Pages: 185-195

    • DOI

      10.1016/j.neo.2016.12.010

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition.2017

    • Author(s)
      Lin J, Chung S, Ueda K, Matsuda K, Nakamura Y, Park JH.
    • Journal Title

      Neoplasia

      Volume: 19 Issue: 1 Pages: 43-53

    • DOI

      10.1016/j.neo.2016.11.007

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p532017

    • Author(s)
      Miyamoto, T., Lo, PHY., Saichi, N., Ueda, K., Hirata, M., Tanikawa, C. and Matsuda, K.
    • Journal Title

      Science Advances

      Volume: in press

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological Changes, Cadherin Switching, and Growth Suppression in Pancreatic Cancer by GALNT6 Knockdown2016

    • Author(s)
      Tarhan, Y. E., Kato, T., Jang, M., Haga, Y., Ueda, K., Nakamura, Y. and Park, J. H.
    • Journal Title

      Neoplasia

      Volume: 18 Issue: 5 Pages: 265-72

    • DOI

      10.1016/j.neo.2016.03.005

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA2016

    • Author(s)
      Shimoda A, Ueda K, Nishiumi S, Murata-Kamiya N, Mukai SA, Sawada S, Azuma T, Hatakeyama M, Akiyoshi K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 18346-18346

    • DOI

      10.1038/srep18346

    • NAID

      120005689168

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma.2016

    • Author(s)
      Sakha S, Muramatsu T, Ueda K, Inazawa J:
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 38750-38750

    • DOI

      10.1038/srep38750

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors2016

    • Author(s)
      Nakakido, M., Tamura, K., Chung, S., Ueda, K., Fujii, R., Kiyotani, K. and Nakamura, Y.
    • Journal Title

      International Journal of Oncology

      Volume: 49 Issue: 3 Pages: 868-876

    • DOI

      10.3892/ijo.2016.3607

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A plasma diagnostic model of human T cell leukemia virus-1 associated myelopathy.2015

    • Author(s)
      Ishihara M, Araya N, Sato T, Saichi N, Fujii R, Yamano Y, Sugano S, Ueda K.
    • Journal Title

      Ann Clin Transl Neurol

      Volume: 2(3) Issue: 3 Pages: 231-240

    • DOI

      10.1002/acn3.169

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.2014

    • Author(s)
      Kenbun Sone, Lianhua Piao, Makoto Nakakido, Koji Ueda, Thomas Jenuwein, Yusuke Nakamura, Ryuji Hamamoto
    • Journal Title

      Nature Communications

      Volume: 5 Issue: 1 Pages: 5691-5691

    • DOI

      10.1038/ncomms6691

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes.2014

    • Author(s)
      Koji Ueda, Nobuhisa Ishikawa, Ayako Tatsuguchi, Naomi Saichi, Risa Fujii, Hidewaki Nakagawa
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 6232-6232

    • DOI

      10.1038/srep06232

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.2014

    • Author(s)
      Ryuji Hamamoto, Gouji Toyokawa, Makoto Nakakido, Koji Ueda, Yusuke Nakamura
    • Journal Title

      Cancer Letters

      Volume: 351 Issue: 1 Pages: 126-133

    • DOI

      10.1016/j.canlet.2014.05.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis2014

    • Author(s)
      T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda, and Y. Nakamura
    • Journal Title

      International journal of oncology

      Volume: 45(1) Issue: 1 Pages: 147-56

    • DOI

      10.3892/ijo.2014.2418

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Elucidation of tumor microenvironment networks by in-depth proteome analysis of extracellular vesicles2018

    • Author(s)
      Ueda, K.
    • Organizer
      The 33rd Joint Annual Conference of Biomedical Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Proteomic profiling of exosomes isolated from viable renal cell carcinoma tissues, toward development of cancer liquid biopsy diagnostics2018

    • Author(s)
      Ueda, K.
    • Organizer
      US-Japan Workshop for Cancer Research ~Biomarker Discovery for Early Cancer Detection~
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exosomal Liquid Biopsy for Early Detection of Kidney Cancer2017

    • Author(s)
      Koji Ueda
    • Organizer
      The 4th Annual US Japan Workshop on Cancer Biomarkers
    • Place of Presentation
      Tempe, AZ, USA
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 大腸癌切除組織と組織培養分泌エクソソームの網羅的プロテオーム比較分析による大腸癌リキッドバイオプシー診断法開発2017

    • Author(s)
      村岡賢, 大西なおみ, 池田篤志, 須磨崎真, 長山聡, 植田幸嗣
    • Organizer
      日本細胞外小胞学会2017年年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エクソソームの高深度プロテオミクス解析による癌微小環境ネットワークの解明2017

    • Author(s)
      植田幸嗣
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] エクソソームを標的とした新しい臨床検査2017

    • Author(s)
      植田幸嗣
    • Organizer
      第68回日本電気泳動学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] エクソソーム表面抗原を標的とした腫瘍マーカー開発2017

    • Author(s)
      植田幸嗣
    • Organizer
      第37回日本分子腫瘍マーカー研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] エクソソーム解析2017

    • Author(s)
      植田幸嗣
    • Organizer
      日本プロテオーム学会2017年年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] バイオマーカー研究の最前線2017

    • Author(s)
      植田幸嗣
    • Organizer
      第32回日本肺癌学会ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A proteome-wide catalog of extracellular vesicles, toward development of cancer liquid biopsy diagnostics2017

    • Author(s)
      Ueda, K.
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Proteome-wide profiling of exosomes revealed exosome-driven intercellular communications in gastric cancer microenvironment and macroenvironment2017

    • Author(s)
      Ueda, K.
    • Organizer
      HUPO 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive EV proteomics revealed EV-driven intercellular communications in gastric cancer microenvironment and macroenvironment2017

    • Author(s)
      Ohnishi, N., Saichi, N., Fujii, R., Murakami, K., Matsubara, H., and Ueda, K.
    • Organizer
      The International Society For Extracellular Vesicles 6th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proteome-wide profiling of viable tissue-derived extracellular vesicles for development of early diagnostic biomarkers for colorectal cancer2017

    • Author(s)
      Muraoka, S., Nagayama, S., and Ueda, K.
    • Organizer
      The International Society For Extracellular Vesicles 6th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞外分泌小胞エクソソームによるがん診断2017

    • Author(s)
      Koji Ueda
    • Organizer
      第17回関東ホルモンと癌研究会
    • Place of Presentation
      Tokyo
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Microenvironmental communications within gastrointestinal cancer tissue illustrated by proteome analysis of exosomes2016

    • Author(s)
      Koji Ueda
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Development of personalized cancer immunotherapy by Trans-OMICS analysis2016

    • Author(s)
      Koji Ueda
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      Sendai
    • Year and Date
      2016-09-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Proteogenomic profiling of neoantigens for personalized cancer immunotherapy2016

    • Author(s)
      Koji Ueda
    • Organizer
      HUPO 2016 World Congress
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2016-09-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Trans-OMICS analysis of immunopeptidome for development of personalized cancer immunotherapy2016

    • Author(s)
      Koji Ueda
    • Organizer
      日本プロテオーム学会2016年年会
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-07-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Mass spectrometric characterization of exosomes for realization of cancer liquid biopsy2016

    • Author(s)
      Koji Ueda
    • Organizer
      RIKEN-Max Planck Joint Research 5th Annual Symposium
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2016-04-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エクソソームを利用したがん早期診断法の開発2016

    • Author(s)
      Koji Ueda
    • Organizer
      第23回JBICバイオ関連基盤技術研究会
    • Place of Presentation
      Tokyo
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] エクソソームを利用したがんリキッドバイオプシー診断技術の開発2016

    • Author(s)
      Koji Ueda
    • Organizer
      Urological Research Seminar
    • Place of Presentation
      Osaka
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Quantitative and qualitative profiling of cancer-associated exosomal proteins for development of liquid biopsy diagnostics2015

    • Author(s)
      Koji Ueda
    • Organizer
      日本分子生物学会、生化学会合同学会
    • Place of Presentation
      神戸国際展示場
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Exosomes drive tumor growth and behave as potential diagnostic biomarkers2015

    • Author(s)
      Koji Ueda
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-10-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 血中・髄液中エクソソームの網羅的プロテオーム解析によるリキッドバイオプシー開発2015

    • Author(s)
      植田幸嗣
    • Organizer
      日本認知症学会
    • Place of Presentation
      青森
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Tumor liquid biopsy by circulating extracellular vesicles2015

    • Author(s)
      Koji Ueda
    • Organizer
      HUPO 2015
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 血中・髄液中エクソソームの網羅的プロテオーム解析によるリキッドバイオプシー開発2015

    • Author(s)
      植田幸嗣
    • Organizer
      日本細胞外小胞学会年会
    • Place of Presentation
      広島
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] エクソソームのプロテオミクス解析がもたらす がん診断技術の革新2015

    • Author(s)
      植田幸嗣
    • Organizer
      第28回バイオメディカル分析化学シンポジウム
    • Place of Presentation
      長崎大学
    • Year and Date
      2015-08-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細胞外分泌小胞のプロテオーム解析と診断への応用2015

    • Author(s)
      植田幸嗣
    • Organizer
      日本プロテオーム学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] A three-factor plasma diagnostic model of human T-cell leukemia virus-1 associated myelopathy2015

    • Author(s)
      Koji Ueda
    • Organizer
      17th International Conference on Human Retrovirology
    • Place of Presentation
      Martinique, France
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proteome-wide profiling of circulating exosomes for identification of scirrhous gastric cancer biomarkers2015

    • Author(s)
      Koji Ueda
    • Organizer
      International Society of Extracellular Vesicles (ISEV) 2015
    • Place of Presentation
      Washington, D.C.
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Proteome-wide profiling of serum exosomes for identification of scirrhous gastric cancer biomarkers.2014

    • Author(s)
      Koji Ueda, Isamu Hoshino, Ayako Tatsuguchi, Naomi Saichi, Risa Fujii, Hisahiro Matsubara, and Sumio Sugano
    • Organizer
      13th Human Proteome Organization World Congress
    • Place of Presentation
      Madrid (Spain)
    • Year and Date
      2014-10-06 – 2014-10-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Proteome-wide analysis of circulating extracellular vesicles for cancer early detection.2014

    • Author(s)
      Koji Ueda, Isamu Hoshino, Naomi Saichi, Risa Fujii, Hisahiro Matsubara, and Sumio Sugano
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Circulating exosomes as new biomarker resources for lung cancer.2014

    • Author(s)
      Koji Ueda
    • Organizer
      9th Early Detection Research Network (EDRN) Scientific Workshop
    • Place of Presentation
      Bethesda (USA)
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Comprehensive proteome profiling of circulating extracellular vesicles for development of cancer biomarkers.2014

    • Author(s)
      Koji Ueda
    • Organizer
      第一回日本細胞外小胞学会(JSEV)年会
    • Place of Presentation
      グランドプリンスホテル広島(広島県広島市)
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Development of Exosomal Biomarkers for Scirrhous Gastric Cancer.2014

    • Author(s)
      Koji Ueda, Risa Fujii, Naomi Saichi, Isamu Hoshino, Hisahiro Matsubara, Sumio Sugano
    • Organizer
      日本プロテオーム学会2014年会
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2014-07-15 – 2014-07-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 血中エクソソームの定量プロテオーム解析による腫瘍マーカー開発2014

    • Author(s)
      Koji Ueda
    • Organizer
      第10回日本臨床プロテオーム研究会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] 実験医学 2017年6月号2017

    • Author(s)
      植田 幸嗣
    • Total Pages
      141
    • Publisher
      羊土社
    • ISBN
      4758101647
    • Related Report
      2017 Annual Research Report
  • [Book] 腎臓内科・泌尿器科 第6巻第6号2017

    • Author(s)
      植田 幸嗣
    • Total Pages
      74
    • Publisher
      科学評論社
    • Related Report
      2017 Annual Research Report
  • [Book] 実験医学 2016年6月号 Vol.34 No.92016

    • Author(s)
      植田幸嗣
    • Total Pages
      141
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report
  • [Book] THE LUNG perspectives2016

    • Author(s)
      植田幸嗣
    • Total Pages
      108
    • Publisher
      メディカルレビュー社
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
  • [Book] 医学のあゆみ2015

    • Author(s)
      植田幸嗣
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] Surgery Frontier2015

    • Author(s)
      植田幸嗣
    • Total Pages
      5
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒトTリンパ好性ウイルス-1 (HTLV-1)関連脊髄症(HAM/TSP)の検査方法、及び検査用キット2014

    • Inventor(s)
      植田幸嗣、石原誠人、山野嘉久
    • Industrial Property Rights Holder
      植田幸嗣、石原誠人、山野嘉久
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-226719
    • Filing Date
      2014-11-07
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-05-15  

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