Central neural pathways mediating psychological stress-induced autonomic responses
| Project/Area Number |
26713009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Nagoya University (2015-2016)
Kyoto University (2014) |
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Principal Investigator |
NAKAMURA Kazuhiro 名古屋大学, 医学(系)研究科(研究院), 教授 (00548521)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2014: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | 心理ストレス / 心因性発熱 / ストレス疾患 / 交感神経 / 中枢神経回路 / 体温調節 / 頻脈 / 情動 / ストレス / 自律神経 / 褐色脂肪組織 / 神経回路 / 光遺伝学 / 大脳皮質 / 視床下部 / 大脳辺縁系 |
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| Outline of Final Research Achievements |
Sympathetic responses to psychological stressors, such as increases in body temperature, blood pressure and heart rate, are driven by the central neural pathway from the dorsomedial hypothalamus to the medulla oblongata. In this study, I found a forebrain region that provides stress signals to the dorsomedial hypothalamus by performing experiments with neuroanatomical, in vivo physiological and optogenetic techniques in rats. The results from the experiments suggest a novel forebrain neural pathway driving sympathetic responses to psychological stressors.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, acutely reduces energy expenditure in BAT via neural signals in mice.2016
Author(s)
Yumiko Chiba, Tetsuya Yamada, Sohei Tsukita, Kei Takahashi, Yuichiro Munakata, Yuta Shirai, Shinjiro Kodama, Yoichiro Asai, Takashi Sugisawa, Kenji Uno, Shojiro Sawada, Junta Imai, Kazuhiro Nakamura, Hideki Katagiri
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Journal Title
PLOS ONE
Volume: 11
Issue: 3
Pages: e0150756-e0150756
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 体温調節の神経機構2016
Author(s)
中村和弘
Organizer
第93回日本生理学会大会
Place of Presentation
札幌コンベンションセンター（北海道札幌市）
Year and Date
2016-03-22
Related Report
Invited
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[Presentation] 体温の中枢神経調節2015
Author(s)
中村和弘
Organizer
第53回日本生物物理学会年会
Place of Presentation
金沢大学（石川県金沢市）
Year and Date
2015-09-13
Related Report
Invited
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[Presentation] 体温調節の仕組み2014
Author(s)
中村和弘
Organizer
第18回東北生活習慣病研究会
Place of Presentation
宮城県仙台市
Year and Date
2014-04-16
Related Report
Invited
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