Development of novel personalized drug therapy based on elucidation of drug sensitivity and resistance mechanism in bone and soft tissue tumors

• Project/Area Number: 26713046
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University (2014, 2017-2018); National Cancer Center Japan (2015-2016)
• Principal Investigator: Endo Makoto 九州大学, 大学病院, 助教 (40713433)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000); Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 肉腫 / 薬剤耐性 / 癌

Outline of Final Research Achievements

We developed sarcoma cell lines showing resistance to anticancer drugs such as doxorubicin, pazopanib and eribulin, which were widely used for bone and soft tissue sarcomas. The established drug resistant cell lines were used to analyze genes and proteins involved in drug resistance. Among them, the research using the pazopanib-resistant cell line of synovial sarcoma has succeeded in elucidating the mechanism of drug resistance and published in an English journal. In addition, we have found that HIF1α, a hypoxia-inducible factor involved in drug resistance, is a poor prognostic factor in malignant peripheral nerve sheath tumors and can be a therapeutic target. In leiomyosarcoma, we found that acquisition of drug resistance to eribulin involves overexpression of Class III β-tubulin and published in an English journal.

Academic Significance and Societal Importance of the Research Achievements

本研究成果を発展させ、臨床的な有用性が示されれば、骨軟部肉腫患者の薬物療法において、より効果を期待できる薬剤選択に有用と考えられる。また、本研究で明らかとなった薬物耐性獲得機序を阻害することに成功すれば、薬物療法の効果を長期に持続させることが可能となり、骨軟部肉腫患者の予後改善につながる可能性がある。

Research Products

• [Journal Article] Class III β-Tubulin Overexpression Induces Chemoresistance to Eribulin in a Leiomyosarcoma Cell Line. (2018)
  • Author(s): Yahiro K, Matsumoto Y, Fukushi JI, Kawaguchi KI, Endo M, Setsu N, IIda K, Fukushima S, Nakagawa M, Kimura A, Oda Y, Nakashima Y
  • Journal Title: Anal Cell Pathol Volume: なし Pages: 8987568-8987568
  • DOI: 10.1155/2018/8987568
  • Peer Reviewed / Open Access
• [Journal Article] Class III b-tubulin overexpression induces chemoresistance to eribulin in a leiomyosarcoma cell line. (2018)
  • Author(s): Yahiro K, Matsumoto Y, Fukushi JI, Kawaguchi K, Endo M, Setsu N, Iida K, Fukushima S, Nakagawa M, Kimura A, Oda Y, Nakashima Y.
  • Journal Title: Analytical Cellular Pathology Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells (2017)
  • Author(s): Yokoyama N, Matsunobu T, Matsumoto Y, Fukushi J, Endo M, Hatano M, Nabeshima A, Fukushima S, Okada S, and Iwamoto Y
  • Journal Title: ScイエンチフィcRえぽrts Volume: 7 Issue: 1 Pages: 45332-45332
  • DOI: 10.1038/srep45332
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor (2017)
  • Author(s): Fukushima Suguru、Endo Makoto、Matsumoto Yoshihiro、Fukushi Jun-ichi、Matsunobu Tomoya、Kawaguchi Ken-ichi、Setsu Nokitaka、IIda Keiichiro、Yokoyama Nobuhiko、Nakagawa Makoto、Yahiro Kenichiro、Oda Yoshinao、Iwamoto Yukihide、Nakashima Yasuharu
  • Journal Title: PLOS ONE Volume: 12 Issue: 5 Pages: 0178064-0178064
  • DOI: 10.1371/journal.pone.0178064
  • Peer Reviewed / Open Access
• [Journal Article] Angioleiomyoma mimicking pes anserinus bursitis: A case report. (2017)
  • Author(s): Araki Y, Yoshida A, Chuman H, Kawai A, Tanzawa Y, Endo M, Kobayashi E.
  • Journal Title: Journal of Dermatology Volume: ー Issue: 8
  • DOI: 10.1111/1346-8138.13876
  • Peer Reviewed
• [Journal Article] Fibromatosis of the soleus muscle presenting as pes equinus: A case report. (2016)
  • Author(s): Bekki H, Fukushi J, Mizu-uchi H, Endo M, Oda Y, Iwamoto Y.
  • Journal Title: The Foot and Ankle Online Journal Volume: 9 Pages: 4-4
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of FOXM1 Expression and Antitumor Effect of FOXM1 Inhibition in Synovial Sarcomas (2016)
  • Author(s): Maekawa A, Kohashi K, Kuda M, Iura K, Ishii T, Endo M, Nakatsura T, Iwamoto Y, Oda Y
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 511-511
  • DOI: 10.1186/s12885-016-2542-4
  • Peer Reviewed / Open Access
• [Journal Article] Forty-eight cases of leiomyosarcoma of bone in Japan: A multicenter study from the Japanese musculoskeletal oncology group. (2016)
  • Author(s): Mori T, Nakayama R, Endo M, Hiraga H, Tomita M, Fukase N, Kobayashi E, Kawai A, Ueda T, Morioka H.
  • Journal Title: J Surg Oncol Volume: Sep;114(4) Issue: 4 Pages: 495-500
  • DOI: 10.1002/jso.24322
  • Peer Reviewed / Open Access
• [Journal Article] An update on drug therapy for chordoma (2016)
  • Author(s): Endo M.
  • Journal Title: Gan To Kagaku Ryoho Volume: 43 Pages: 317-321
• [Journal Article] Osteosarcoma of the middle and distal phalanges of the little toe with a cancerous ulcer (2016)
  • Author(s): Matsunobu T, Bekki H, Harimaya K, Matsumoto Y, Endo M, Yoshitake K, Oda Y, Iwamoto Y.
  • Journal Title: International Journal of Case Reports and Images Volume: 7 Issue: 3 Pages: 185-189
  • DOI: 10.5348/ijcri-201632-cr-10619
  • Peer Reviewed / Open Access
• [Journal Article] 悪性軟部腫瘍に対するトラベクテジン (2016)
  • Author(s): 遠藤誠、川井章
  • Journal Title: 腫瘍内科 Volume: 18 Pages: 176-182
  • NAID: 40020943818
• [Journal Article] 【がん標的分子と治療開発-現状と将来】各臓器別の新薬開発の現状と将来 骨・軟部腫瘍 (2016)
  • Author(s): 遠藤誠、川井章
  • Journal Title: 医学のあゆみ Volume: 258 Pages: 591-597
• [Journal Article] 小児四肢悪性骨腫瘍に対する患肢・機能温存の試みと課題 (2016)
  • Author(s): 遠藤誠、川井章
  • Journal Title: 日本小児血液・がん学会雑誌 Volume: 52 Pages: 369-375
  • NAID: 130005125273
• [Journal Article] 希少がん入門 骨の肉腫 (2016)
  • Author(s): 遠藤誠
  • Journal Title: Clinic Magazine Volume: 43 Pages: 36-37
• [Journal Article] MR imaging findings of a leiomyosarcoma of the thoracic spine: A case report. (2015)
  • Author(s): Tahara K, Yamashita K, Hiwatashi A, et al.
  • Journal Title: Clin Neuroradiol. Volume: Epub ahead of print Issue: 2 Pages: 1-5
  • DOI: 10.1007/s00062-015-0420-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] NY-ESO-1 (CTAG1B) expression in mesenchymal tumors (2015)
  • Author(s): Endo M, de Graaff MA, Ingram DR, Lim S, Lev DC, Briaire-de Bruijn IH, Somaiah N, Bovée JV, Lazar AJ, Nielsen TO.
  • Journal Title: Mod Pathol Volume: 28 Issue: 4 Pages: 587-95
  • DOI: 10.1038/modpathol.2014.155
  • Peer Reviewed
• [Journal Article] Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. (2015)
  • Author(s): Salanti A, Clausen TM, Agerbaek M, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M.
  • Journal Title: Cancer Cell Volume: 28 Issue: 4 Pages: 500-14
  • DOI: 10.1016/j.ccell.2015.09.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200†. (2015)
  • Author(s): Chu QS, Nielsen TO, Alcindor T, Gupta A, Endo M, Goytain A, Xu H, Verma S, Tozer R, Knowling M, Bramwell VB, Powers J, Seymour LK, Eisenhauer EA.
  • Journal Title: Ann Oncol Volume: 26 Issue: 5 Pages: 973-81
  • DOI: 10.1093/annonc/mdv033
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways (2015)
  • Author(s): Nabeshima Y., Matsumoto Y., Iwamoto Y., et al
  • Journal Title: British J Cancer Volume: NA Issue: 3 Pages: 1-9
  • DOI: 10.1038/bjc.2014.637
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone. (2015)
  • Author(s): Hatano M, Matsumoto Y, Fukushi J, Matsunobu T, Endo M, Okada S, Iura K, Kamura S, Fujiwara T, Iida K, Fujiwara Y, Nabeshima A, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y.
  • Journal Title: Clin Exp Metastasis. Volume: 32 Issue: 6 Pages: 579-591
  • DOI: 10.1007/s10585-015-9729-y
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas (2014)
  • Author(s): Takahashi Y, Kohashi K, Yamada Y, Endo M, Setsu N, Ishii T, Yamamoto H, Iwamoto Y, Oda Y
  • Journal Title: Hum Pathol Volume: 45(5) Issue: 5 Pages: 984-993
  • DOI: 10.1016/j.humpath.2013.12.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Malignant peripheral nerve sheath tumors presenting as spinal dumbbell tumors: clinical outcomes and characteristic imaging features (2014)
  • Author(s): Matsumoto Y, Endo M, Harimaya K, Hayashida M, Doi T, Iwamoto Y.
  • Journal Title: Eur Spine J Volume: Epub
  • Peer Reviewed
• [Presentation] 悪性軟部腫瘍に対するトラベクテジンの腫瘍反応に関する時間経過分析:国内第II相 試験の統合解析 (2019)
  • Author(s): 遠藤 誠、髙橋 俊二、荒木 信人、杉浦 英志、上田 孝文、米本 司、高橋 満、森岡 秀夫、平賀 博明、比留間 徹、川井 章
  • Organizer: 第2回日本サルコーマ治療研究学会 学術集会
• [Presentation] 軟骨肉腫に対するIDH変異を標的とした新規分子標的治療の開発 (2018)
  • Author(s): 中川 亮, 中谷 文彦, 遠藤 誠, 川井 章, 吉田 朗彦, 八尋 健一郎, 木村 敦, 関 剛彦, 荒木 一司, 北林 一生, 中島 康晴
  • Organizer: 第33回日本整形外科学会 基礎学術集会
• [Presentation] C3HマウスにおいてLPSによるTLR4の活性化はマウス骨肉腫細胞株であるLM8の成長を抑制する (2018)
  • Author(s): 八尋 健一郎, 松本 嘉寛, 遠藤 誠, 薛 宇孝, 木村 敦, 山田 久方, 中島 康晴
  • Organizer: 第51回日本整形外科学会 骨軟部腫瘍学術集会
• [Presentation] 平滑筋肉腫患者におけるclass 3βチューブリンの発現は予後と相関する (2018)
  • Author(s): 八尋 健一郎, 松本 嘉寛, 遠藤 誠, 薛 宇孝, 木村 敦, 小田 義直, 中島 康晴
  • Organizer: 第51回日本整形外科学会 骨軟部腫瘍学術集会
• [Presentation] 滑膜肉腫におけるNY-ESO-1発現と新規治療開発の展望 (2018)
  • Author(s): 遠藤 誠, 薛 宇孝, 松本 嘉寛, 木村 敦, 八尋 健一郎, Nielsen Torsten, 中島 康晴
  • Organizer: 第135回西日本整形・災害外科学会
• [Presentation] 軟骨肉腫におけるIDH変異と2HGのバイオマーカーとしての有用性 (2018)
  • Author(s): 中川 亮, 中谷 文彦, 遠藤 誠, 松本 嘉寛, 川井 章, 吉田 朗彦, 関 剛彦, 荒木 一司, 北林 一生, 中島 康晴
  • Organizer: 第91回日本整形外科学会 学術総会
• [Presentation] Volume-outcome relationship in sarcoma treatment (2017)
  • Author(s): Endo M, Tomizuka T, Higashi T, Kawai A.
  • Organizer: 2017 Annual Meeting of Connective Tissue Oncology Society
  • Int'l Joint Research
• [Presentation] Treatment patterns, clinical outcomes and prognostic factors of visceral angiosarcoma (V-AS): A report from the Asian Sarcoma Consortium (ASC) (2017)
  • Author(s): Pang A, Ngan R, Tan SH, Hirose T, Endo M, Farid M, Goh WL, Loong HH, Mingmalairak S, Chang CC, Teo S, Maw MM, Leung AKC, Chan JC, Puhaindran ME, Kawai A, Chen WW, Quek R, Sriuranpong V.
  • Organizer: The 42nd European Society for Medical Oncology Congress
  • Int'l Joint Research
• [Presentation] National survey of treatment of bone and soft tissue sarcoma patients in Japan : the distribution of patients and medical specialties by cancer topography and treatment modality. (2017)
  • Author(s): Endo M, Iwamoto M, Sugawara M, Araki Y, Mori T, Shimizu K, Setsu N, Kobayashi E, Tanzawa Y, Nakatani F, Chuman H, Higashi T, Kawai A.
  • Organizer: The 19th International Society of Limb Salvage General Meeting
  • Int'l Joint Research
• [Presentation] 小児がん治療後の整形外科的諸問題 (2017)
  • Author(s): 遠藤誠, 土持兼信、河野紘一郎、池村聡、藤井政徳、濱井敏、本村悟朗、福士純一、横山良平、中島康晴
  • Organizer: 第28回日本小児整形外科学会学術集会
  • Invited
• [Presentation] 進行又は再発悪性軟部腫瘍に対するエリブリンの治療経験 (2017)
  • Author(s): 横山信彦、松本嘉寛、飯田圭一郎、薛宇孝、遠藤誠、中島康晴
  • Organizer: 第133回西日本整形・災害外科学会
• [Presentation] 悪性末梢神経鞘腫瘍の薬剤耐性機序の検討 (2017)
  • Author(s): 福島俊、松本嘉寛、鍋島央、遠藤誠、薛宇孝、飯田圭一郎、横山信彦、中川亮、八尋健一郎、中島康晴
  • Organizer: 第133回西日本整形・災害外科学会
• [Presentation] CIC-rearranged sarcoma and BCOR-CCNB3 sarcoma: Clinical characteristics and treatment results of the newly-established “Ewing sarcoma-like” small round cell sarcomas (2016)
  • Author(s): Endo M, Sugawara M, Yoshida A, Kobayashi E, Shimoi T, Kodaira M, Yunokawa M, Yonemori K, Tamura K, Toki S, Hirose T, Uehara T, Mori T, Shimizu K, Tanzawa Y, Nakatani F, Chuman H, Kawai A.
  • Organizer: The European Society for Medical Oncology Asia 2016 Annual Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2016-12-16
  • Int'l Joint Research
• [Presentation] Epidemiology, real world treatment and outcomes of 423 patients (pts) with angiosarcoma (AS) in Asia: A report from the Asian Sarcoma Consortium (ASC) (2016)
  • Author(s): Quek R, Loong HH, Sriuranpong V, Farid M, Tan S, Goh W, Mingmalairak S, Chen TW, Chang C, Pang A, Teo S, Puhaindran ME, Maw M, Ngan R, Leung AK, Chan JC, Hirose T, Endo M, Kawai A.
  • Organizer: The European Society for Medical Oncology Asia 2016 Annual Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2016-12-16
  • Int'l Joint Research
• [Presentation] Optimal first line systemic therapy in patients (pts) with metastatic angiosarcoma: A report from the Asian Sarcoma Consortium (2016)
  • Author(s): Chen TW, Pang A, Puhaindran ME, Maw M, Loong HH, Sriuranpong V, Chang C, Teo S, Mingmalairak S, Hirose T, Endo M, Kawai A, Farid M, Tan S, Goh W, Quek R, Chan JC, Leung AK, Ngan R
  • Organizer: The European Society for Medical Oncology Asia 2016 Annual Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2016-12-16
  • Int'l Joint Research
• [Presentation] Immunotherapy targeting NY-ESO-1 for sarcomas (2016)
  • Author(s): Endo M
  • Organizer: The 21st Annual Scientific Symposium of the Hong Kong Cancer Institute
  • Place of Presentation: Hong Kong
  • Year and Date: 2016-11-19
  • Int'l Joint Research / Invited
• [Presentation] CIC-rearranged sarcomas: clinical features and treatment outcome (2016)
  • Author(s): Endo M, Yoshida A, Kobayashi E, Toki S, Hirose T, Uehara T, Sugawara M, Mori T, Shimizu K, Tanzawa Y, Nakatani F, Chuman H, Kawai A.
  • Organizer: The 21th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Lisbon, Portuguel
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Clinicopathological findings and treatment results of BCOR-CCNB3 sarcoma (2016)
  • Author(s): Sugawara M, Endo M, Yoshida A, Kobayashi E, Tanzawa Y, Nakatani F, Takagi M, Chuman H, Kawai A
  • Organizer: The 21th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Lisbon, Portuguel
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Identification of a possible therapeutic candidate for advanced chondrosarcoma with an IDH1 mutant inhibitor (2016)
  • Author(s): Nakagawa M, Nakatani F, Endo M, Kobayashi E, Tanzawa Y, Kawai A, Chuman H, Yoshida A, Seki T, Araki K, Iwamoto Y, Kitabayashi I
  • Organizer: The 21th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Lisbon, Portuguel
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] A refractory desmoid-type fibromatosis with a remarkable response to pazopanib Treatment (2016)
  • Author(s): Kobayashi E, Endo M, Tanzawa Y, Nakatani F, Chuman H, Kawai A
  • Organizer: The 21th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Lisbon, Portuguel
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Mechanisim of pazopanib resistance in synovial sarcoma. (2016)
  • Author(s): Matsumoto Y, Yokoyama N, Matsunobu T, Endo M, Setsu N, Iida K, Fukushima S, Iwamoto Y.
  • Organizer: The 21th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Lisbon, Portuguel
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Treatment of bone and soft-tissue sarcoma patients in Japan; the distribution of patients and medical specialties by cancer topography and treatment modality (2016)
  • Author(s): Endo M, Iwamoto M, Toki S, Hirose T, Uehara T, Sugawara M, Mori T, Shimizu K, Kobayashi E, Tanzawa Y, Nakatani F, Chuman H, Higashi T, Kawai A.
  • Organizer: The 21th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Lisbon, Portuguel
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Clinical features, treatment and prognosis of angiosarcoma involving the spine. (2016)
  • Author(s): Hirose T, Endo M, Yoshida A, Nakano R, Toki S, Uehara T, Sugawara M, Araki Y, Mori T, Shimizu K, Kobayashi E, Tanzawa Y, Nakatani F, Chuman H, Kawai A
  • Organizer: The 21th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Lisbon, Portuguel
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] 悪性末梢神経鞘腫瘍に対する低酸素誘導因子阻害剤の有効性の検討 (2016)
  • Author(s): 福島俊、松本嘉寛、中川亮、横山信彦、鍋島央、畑野美穂子、遠藤誠、松延知哉、福士純一、播广谷勝三、小田義直、岩本幸英
  • Organizer: 第49回日本整形外科学会 骨軟部腫瘍学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
• [Presentation] 滑膜肉腫細胞株におけるパゾパニブへの獲得耐性メカニズムの検討 (2016)
  • Author(s): 横山信彦、松延知哉、福島俊、鍋島央、畑野美穂子、遠藤誠、松本嘉寛、福士純一、播广谷勝三、岩本幸英
  • Organizer: 第49回日本整形外科学会 骨軟部腫瘍学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
• [Presentation] 軟部肉腫81例におけるpazopanibの使用経験 (2016)
  • Author(s): 小林英介, 薛宇孝, 清水光樹, 菅原正登, 荒木麗博, 森智章, 中谷文彦, 遠藤誠, 丹沢義一, 川井章, 中馬広一
  • Organizer: 第49回日本整形外科学会 骨軟部腫瘍学術集会
  • Place of Presentation: 東京
  • Year and Date: 2016-07-14
• [Presentation] がん精巣抗原NY-ESO-1の骨腫瘍における発現 (2016)
  • Author(s): 遠藤誠, 小林英介, 丹澤義一, 中谷文彦, 川井章, 中馬広一, Nielsen Torsten
  • Organizer: 第89回日本整形外科学会 学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-05-12
  • Int'l Joint Research
• [Presentation] Forty-eight cases of Leiomyosarcoma of Bone in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group (2016)
  • Author(s): Mori T, Nakayama R, Endo M, Kobayashi E, Kawai A, Ueda T, Morioka H
  • Organizer: The 11th Asia Pacific Musculoskeletal Tumour Society Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2016-04-21
  • Int'l Joint Research
• [Presentation] Malignant glomus tumour treated with pazopanib. (2015)
  • Author(s): Endo M, Bekki H, Kobayashi E, Tanzawa Y, Nakatani F, Kawai A, Chuman H, Oda Y, Iwamoto Y
  • Organizer: The European Society for Medical Oncology Asia 2015 Annual Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2015-12-18
  • Int'l Joint Research
• [Presentation] PTEN Expression Is A Good Prognostic Marker In Malignant Peripheral Nerve Sheath Tumors. (2015)
  • Author(s): M. Endo, N. Setsu, E. Kobayashi, Y. Tanzawa, F. Nakatani, A. Kawai, H. Chuman, M. Hakozaki, K. Kohashi, H. Yamamoto, Y. Oda, T. Matsunobu, Y. Matsumoto, K. Harimaya, Y. Iwamoto.
  • Organizer: The 20th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Salt Lake City, USA
  • Year and Date: 2015-11-04
  • Int'l Joint Research
• [Presentation] Multi-targeted Tyrosine Kinase Inhibitors For Alveolar Soft Part Sarcomas. (2015)
  • Author(s): Eisuke Kobayashi, Makoto Endo, Yoshikazu Tanzawa, Fumihiko Nakatani, Hirokazu Chuman, Akira Kawai
  • Organizer: The 20th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Salt Lake City, USA
  • Year and Date: 2015-11-04
  • Int'l Joint Research
• [Presentation] Angiomatoid Fibrous Histiocytoma: A Report Of Eight Cases. (2015)
  • Author(s): Yoshihiro Araki, Eisuke Kobayashi, Makoto Endo, Yoshikazu Tanzawa, Fumihiko Nakatani, Akira Kawai, Hirokazu Chuman
  • Organizer: The 20th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Salt Lake City, USA
  • Year and Date: 2015-11-04
  • Int'l Joint Research
• [Presentation] Exploratory research for prognostic factors and novel therapeutic targets in bone and soft tissue tumors. (2015)
  • Author(s): Endo M
  • Organizer: The 74th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2015-10-08
  • Int'l Joint Research / Invited
• [Presentation] A pelvic tumor. (2015)
  • Author(s): Oda Y, Yamamoto H, Kohashi K, Endo M
  • Organizer: The International Skeletal Society 42nd Annual Meeting
  • Place of Presentation: Maui, USA
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Safety and efficiency of salvage chemotherapy with ifosfamide, carboplatin and etoposide for malignant bone and soft tissue tumors. (2015)
  • Author(s): Endo M, Hirose T, Matsunobu T, Matsumoto Y, Harimaya K, Tamura S, Kusaba H, Oda Y, Iwamoto Y.
  • Organizer: The Japanese Society of Medical Oncology 2015 Annual Meeting
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-07-16
  • Int'l Joint Research
• [Presentation] Safety and efficiency of chemotherapy with ifosfamide, carboplatin and etoposide for bone and soft tissue sarcomas (2015)
  • Author(s): Endo M, Hirose T, Matsumoto Y, Matsunobu T, Harimaya K, Oda Y, Iwamoto Y.
  • Organizer: The 88th Annual Meeting of the Japanese Orthopaedic Association
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-05-21
  • Int'l Joint Research
• [Presentation] Clinical outcome of primary leiomyosarcoma of bone（LMSOB）: A multicenter study in Japan. (2015)
  • Author(s): Mori T, Endo M, Fukase N, Hiraga H, Tomita M, Kobayashi E, Shinoda Y, Ueda T, Morioka H, Toyama Y
  • Organizer: The 88th Annual Meeting of the Japanese Orthopaedic Association
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-05-21
  • Int'l Joint Research
• [Presentation] Activation Status of AKT-mTOR and MAPK Pathways in Malignant Peripheral Nerve Sheath Tumors: Which Pathway Affects a Patient’s Survival? (2014)
  • Author(s): Endo M, Setsu N, Kohashi K, Yamamoto H, Matsunobu T, Matsumoto Y, Harimaya K, Iwamoto Y, Oda Y.
  • Organizer: The 19th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Ifosfamide, Carboplatin, and Etoposide (ICE) for Metastatic or Refractory Bone and Soft Tissue Sarcomas (2014)
  • Author(s): Hirose T, Endo M, Matsumoto Y, Matsunobu T, Harimaya K, Oda Y, Iwamoto Y.
  • Organizer: The 19th Annual Meeting of Connective Tissue Oncology Society
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 悪性末梢神経鞘腫瘍におけるPTENの発現解析と予後的意義の検討 (2014)
  • Author(s): 遠藤誠、薛宇孝、箱崎道之、戸次大史、井浦国生、前川啓、石井武彰、高橋祐介、山田裕一、孝橋賢一、山元英崇、松延知哉、松本嘉寛、播广谷勝三、岩本幸英、小田義直
  • Organizer: 第47回日本整形外科学会 骨軟部腫瘍学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] 悪性骨腫瘍に対するsecond line化学療法としてのifosfamide, carboplatin, etoposide併用療法(ICE療法)の安全性と有効性の検討 (2014)
  • Author(s): 廣瀬毅、遠藤誠、松本嘉寛、松延知哉、播广谷勝三、小田義直、岩本幸英
  • Organizer: 第47回日本整形外科学会 骨軟部腫瘍学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] 骨・軟部腫瘍を含む間葉系腫瘍におけるMCL1およびBCL2タンパク発現の網羅的解析 (2014)
  • Author(s): 遠藤誠、松延知哉、松本嘉寛、播广谷勝三、Nielsen TO、小田義直、岩本幸英
  • Organizer: 第87回日本整形外科学会 学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-05-22 – 2014-05-25
• [Remarks] 九州大学 研究者情報
  • URL: http://hyoka.ofc.kyushu-u.ac.jp/search/details/K004977/index.html