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Development of novel personalized drug therapy based on elucidation of drug sensitivity and resistance mechanism in bone and soft tissue tumors

Research Project

Project/Area Number 26713046
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Orthopaedic surgery
Research InstitutionKyushu University (2014, 2017-2018)
National Cancer Center Japan (2015-2016)

Principal Investigator

Endo Makoto  九州大学, 大学病院, 助教 (40713433)

Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords肉腫 / 薬剤耐性 / 癌
Outline of Final Research Achievements

We developed sarcoma cell lines showing resistance to anticancer drugs such as doxorubicin, pazopanib and eribulin, which were widely used for bone and soft tissue sarcomas. The established drug resistant cell lines were used to analyze genes and proteins involved in drug resistance. Among them, the research using the pazopanib-resistant cell line of synovial sarcoma has succeeded in elucidating the mechanism of drug resistance and published in an English journal. In addition, we have found that HIF1α, a hypoxia-inducible factor involved in drug resistance, is a poor prognostic factor in malignant peripheral nerve sheath tumors and can be a therapeutic target. In leiomyosarcoma, we found that acquisition of drug resistance to eribulin involves overexpression of Class III β-tubulin and published in an English journal.

Academic Significance and Societal Importance of the Research Achievements

本研究成果を発展させ、臨床的な有用性が示されれば、骨軟部肉腫患者の薬物療法において、より効果を期待できる薬剤選択に有用と考えられる。また、本研究で明らかとなった薬物耐性獲得機序を阻害することに成功すれば、薬物療法の効果を長期に持続させることが可能となり、骨軟部肉腫患者の予後改善につながる可能性がある。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (65 results)

All 2019 2018 2017 2016 2015 2014 Other

All Journal Article (22 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 11 results,  Acknowledgement Compliant: 5 results) Presentation (42 results) (of which Int'l Joint Research: 25 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] Class III β-Tubulin Overexpression Induces Chemoresistance to Eribulin in a Leiomyosarcoma Cell Line.2018

    • Author(s)
      Yahiro K, Matsumoto Y, Fukushi JI, Kawaguchi KI, Endo M, Setsu N, IIda K, Fukushima S, Nakagawa M, Kimura A, Oda Y, Nakashima Y
    • Journal Title

      Anal Cell Pathol

      Volume: なし Pages: 8987568-8987568

    • DOI

      10.1155/2018/8987568

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Class III b-tubulin overexpression induces chemoresistance to eribulin in a leiomyosarcoma cell line.2018

    • Author(s)
      Yahiro K, Matsumoto Y, Fukushi JI, Kawaguchi K, Endo M, Setsu N, Iida K, Fukushima S, Nakagawa M, Kimura A, Oda Y, Nakashima Y.
    • Journal Title

      Analytical Cellular Pathology

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells2017

    • Author(s)
      Yokoyama N, Matsunobu T, Matsumoto Y, Fukushi J, Endo M, Hatano M, Nabeshima A, Fukushima S, Okada S, and Iwamoto Y
    • Journal Title

      ScイエンチフィcRえぽrts

      Volume: 7 Issue: 1 Pages: 45332-45332

    • DOI

      10.1038/srep45332

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor2017

    • Author(s)
      Fukushima Suguru、Endo Makoto、Matsumoto Yoshihiro、Fukushi Jun-ichi、Matsunobu Tomoya、Kawaguchi Ken-ichi、Setsu Nokitaka、IIda Keiichiro、Yokoyama Nobuhiko、Nakagawa Makoto、Yahiro Kenichiro、Oda Yoshinao、Iwamoto Yukihide、Nakashima Yasuharu
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: 0178064-0178064

    • DOI

      10.1371/journal.pone.0178064

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Angioleiomyoma mimicking pes anserinus bursitis: A case report.2017

    • Author(s)
      Araki Y, Yoshida A, Chuman H, Kawai A, Tanzawa Y, Endo M, Kobayashi E.
    • Journal Title

      Journal of Dermatology

      Volume: ー Issue: 8

    • DOI

      10.1111/1346-8138.13876

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibromatosis of the soleus muscle presenting as pes equinus: A case report.2016

    • Author(s)
      Bekki H, Fukushi J, Mizu-uchi H, Endo M, Oda Y, Iwamoto Y.
    • Journal Title

      The Foot and Ankle Online Journal

      Volume: 9 Pages: 4-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Significance of FOXM1 Expression and Antitumor Effect of FOXM1 Inhibition in Synovial Sarcomas2016

    • Author(s)
      Maekawa A, Kohashi K, Kuda M, Iura K, Ishii T, Endo M, Nakatsura T, Iwamoto Y, Oda Y
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 511-511

    • DOI

      10.1186/s12885-016-2542-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forty-eight cases of leiomyosarcoma of bone in Japan: A multicenter study from the Japanese musculoskeletal oncology group.2016

    • Author(s)
      Mori T, Nakayama R, Endo M, Hiraga H, Tomita M, Fukase N, Kobayashi E, Kawai A, Ueda T, Morioka H.
    • Journal Title

      J Surg Oncol

      Volume: Sep;114(4) Issue: 4 Pages: 495-500

    • DOI

      10.1002/jso.24322

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An update on drug therapy for chordoma2016

    • Author(s)
      Endo M.
    • Journal Title

      Gan To Kagaku Ryoho

      Volume: 43 Pages: 317-321

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Osteosarcoma of the middle and distal phalanges of the little toe with a cancerous ulcer2016

    • Author(s)
      Matsunobu T, Bekki H, Harimaya K, Matsumoto Y, Endo M, Yoshitake K, Oda Y, Iwamoto Y.
    • Journal Title

      International Journal of Case Reports and Images

      Volume: 7 Issue: 3 Pages: 185-189

    • DOI

      10.5348/ijcri-201632-cr-10619

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 悪性軟部腫瘍に対するトラベクテジン2016

    • Author(s)
      遠藤誠、川井章
    • Journal Title

      腫瘍内科

      Volume: 18 Pages: 176-182

    • NAID

      40020943818

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 【がん標的分子と治療開発-現状と将来】各臓器別の新薬開発の現状と将来 骨・軟部腫瘍2016

    • Author(s)
      遠藤誠、川井章
    • Journal Title

      医学のあゆみ

      Volume: 258 Pages: 591-597

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 小児四肢悪性骨腫瘍に対する患肢・機能温存の試みと課題2016

    • Author(s)
      遠藤誠、川井章
    • Journal Title

      日本小児血液・がん学会雑誌

      Volume: 52 Pages: 369-375

    • NAID

      130005125273

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 希少がん入門 骨の肉腫2016

    • Author(s)
      遠藤誠
    • Journal Title

      Clinic Magazine

      Volume: 43 Pages: 36-37

    • Related Report
      2016 Annual Research Report
  • [Journal Article] MR imaging findings of a leiomyosarcoma of the thoracic spine: A case report.2015

    • Author(s)
      Tahara K, Yamashita K, Hiwatashi A, et al.
    • Journal Title

      Clin Neuroradiol.

      Volume: Epub ahead of print Issue: 2 Pages: 1-5

    • DOI

      10.1007/s00062-015-0420-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NY-ESO-1 (CTAG1B) expression in mesenchymal tumors2015

    • Author(s)
      Endo M, de Graaff MA, Ingram DR, Lim S, Lev DC, Briaire-de Bruijn IH, Somaiah N, Bovée JV, Lazar AJ, Nielsen TO.
    • Journal Title

      Mod Pathol

      Volume: 28 Issue: 4 Pages: 587-95

    • DOI

      10.1038/modpathol.2014.155

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein.2015

    • Author(s)
      Salanti A, Clausen TM, Agerbaek M, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M.
    • Journal Title

      Cancer Cell

      Volume: 28 Issue: 4 Pages: 500-14

    • DOI

      10.1016/j.ccell.2015.09.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200†.2015

    • Author(s)
      Chu QS, Nielsen TO, Alcindor T, Gupta A, Endo M, Goytain A, Xu H, Verma S, Tozer R, Knowling M, Bramwell VB, Powers J, Seymour LK, Eisenhauer EA.
    • Journal Title

      Ann Oncol

      Volume: 26 Issue: 5 Pages: 973-81

    • DOI

      10.1093/annonc/mdv033

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tumour-associated macrophages correlate with poor prognosis in myxoid liposarcoma and promote cell motility and invasion via the HB-EGF-EGFR-PI3K/Akt pathways2015

    • Author(s)
      Nabeshima Y., Matsumoto Y., Iwamoto Y., et al
    • Journal Title

      British J Cancer

      Volume: NA Issue: 3 Pages: 1-9

    • DOI

      10.1038/bjc.2014.637

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone.2015

    • Author(s)
      Hatano M, Matsumoto Y, Fukushi J, Matsunobu T, Endo M, Okada S, Iura K, Kamura S, Fujiwara T, Iida K, Fujiwara Y, Nabeshima A, Yokoyama N, Fukushima S, Oda Y, Iwamoto Y.
    • Journal Title

      Clin Exp Metastasis.

      Volume: 32 Issue: 6 Pages: 579-591

    • DOI

      10.1007/s10585-015-9729-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas2014

    • Author(s)
      Takahashi Y, Kohashi K, Yamada Y, Endo M, Setsu N, Ishii T, Yamamoto H, Iwamoto Y, Oda Y
    • Journal Title

      Hum Pathol

      Volume: 45(5) Issue: 5 Pages: 984-993

    • DOI

      10.1016/j.humpath.2013.12.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Malignant peripheral nerve sheath tumors presenting as spinal dumbbell tumors: clinical outcomes and characteristic imaging features2014

    • Author(s)
      Matsumoto Y, Endo M, Harimaya K, Hayashida M, Doi T, Iwamoto Y.
    • Journal Title

      Eur Spine J

      Volume: Epub

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 悪性軟部腫瘍に対するトラベクテジンの腫瘍反応に関する時間経過分析:国内第II相 試験の統合解析2019

    • Author(s)
      遠藤 誠、髙橋 俊二、荒木 信人、杉浦 英志、上田 孝文、米本 司、高橋 満、森岡 秀夫、平賀 博明、比留間 徹、川井 章
    • Organizer
      第2回日本サルコーマ治療研究学会 学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 軟骨肉腫に対するIDH変異を標的とした新規分子標的治療の開発2018

    • Author(s)
      中川 亮, 中谷 文彦, 遠藤 誠, 川井 章, 吉田 朗彦, 八尋 健一郎, 木村 敦, 関 剛彦, 荒木 一司, 北林 一生, 中島 康晴
    • Organizer
      第33回日本整形外科学会 基礎学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] C3HマウスにおいてLPSによるTLR4の活性化はマウス骨肉腫細胞株であるLM8の成長を抑制する2018

    • Author(s)
      八尋 健一郎, 松本 嘉寛, 遠藤 誠, 薛 宇孝, 木村 敦, 山田 久方, 中島 康晴
    • Organizer
      第51回日本整形外科学会 骨軟部腫瘍学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 平滑筋肉腫患者におけるclass 3βチューブリンの発現は予後と相関する2018

    • Author(s)
      八尋 健一郎, 松本 嘉寛, 遠藤 誠, 薛 宇孝, 木村 敦, 小田 義直, 中島 康晴
    • Organizer
      第51回日本整形外科学会 骨軟部腫瘍学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 滑膜肉腫におけるNY-ESO-1発現と新規治療開発の展望2018

    • Author(s)
      遠藤 誠, 薛 宇孝, 松本 嘉寛, 木村 敦, 八尋 健一郎, Nielsen Torsten, 中島 康晴
    • Organizer
      第135回西日本整形・災害外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 軟骨肉腫におけるIDH変異と2HGのバイオマーカーとしての有用性2018

    • Author(s)
      中川 亮, 中谷 文彦, 遠藤 誠, 松本 嘉寛, 川井 章, 吉田 朗彦, 関 剛彦, 荒木 一司, 北林 一生, 中島 康晴
    • Organizer
      第91回日本整形外科学会 学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Volume-outcome relationship in sarcoma treatment2017

    • Author(s)
      Endo M, Tomizuka T, Higashi T, Kawai A.
    • Organizer
      2017 Annual Meeting of Connective Tissue Oncology Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Treatment patterns, clinical outcomes and prognostic factors of visceral angiosarcoma (V-AS): A report from the Asian Sarcoma Consortium (ASC)2017

    • Author(s)
      Pang A, Ngan R, Tan SH, Hirose T, Endo M, Farid M, Goh WL, Loong HH, Mingmalairak S, Chang CC, Teo S, Maw MM, Leung AKC, Chan JC, Puhaindran ME, Kawai A, Chen WW, Quek R, Sriuranpong V.
    • Organizer
      The 42nd European Society for Medical Oncology Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] National survey of treatment of bone and soft tissue sarcoma patients in Japan : the distribution of patients and medical specialties by cancer topography and treatment modality.2017

    • Author(s)
      Endo M, Iwamoto M, Sugawara M, Araki Y, Mori T, Shimizu K, Setsu N, Kobayashi E, Tanzawa Y, Nakatani F, Chuman H, Higashi T, Kawai A.
    • Organizer
      The 19th International Society of Limb Salvage General Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小児がん治療後の整形外科的諸問題2017

    • Author(s)
      遠藤誠, 土持兼信、河野紘一郎、池村聡、藤井政徳、濱井敏、本村悟朗、福士純一、横山良平、中島康晴
    • Organizer
      第28回日本小児整形外科学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 進行又は再発悪性軟部腫瘍に対するエリブリンの治療経験2017

    • Author(s)
      横山信彦、松本嘉寛、飯田圭一郎、薛宇孝、遠藤誠、中島康晴
    • Organizer
      第133回西日本整形・災害外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 悪性末梢神経鞘腫瘍の薬剤耐性機序の検討2017

    • Author(s)
      福島俊、松本嘉寛、鍋島央、遠藤誠、薛宇孝、飯田圭一郎、横山信彦、中川亮、八尋健一郎、中島康晴
    • Organizer
      第133回西日本整形・災害外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] CIC-rearranged sarcoma and BCOR-CCNB3 sarcoma: Clinical characteristics and treatment results of the newly-established “Ewing sarcoma-like” small round cell sarcomas2016

    • Author(s)
      Endo M, Sugawara M, Yoshida A, Kobayashi E, Shimoi T, Kodaira M, Yunokawa M, Yonemori K, Tamura K, Toki S, Hirose T, Uehara T, Mori T, Shimizu K, Tanzawa Y, Nakatani F, Chuman H, Kawai A.
    • Organizer
      The European Society for Medical Oncology Asia 2016 Annual Meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Epidemiology, real world treatment and outcomes of 423 patients (pts) with angiosarcoma (AS) in Asia: A report from the Asian Sarcoma Consortium (ASC)2016

    • Author(s)
      Quek R, Loong HH, Sriuranpong V, Farid M, Tan S, Goh W, Mingmalairak S, Chen TW, Chang C, Pang A, Teo S, Puhaindran ME, Maw M, Ngan R, Leung AK, Chan JC, Hirose T, Endo M, Kawai A.
    • Organizer
      The European Society for Medical Oncology Asia 2016 Annual Meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimal first line systemic therapy in patients (pts) with metastatic angiosarcoma: A report from the Asian Sarcoma Consortium2016

    • Author(s)
      Chen TW, Pang A, Puhaindran ME, Maw M, Loong HH, Sriuranpong V, Chang C, Teo S, Mingmalairak S, Hirose T, Endo M, Kawai A, Farid M, Tan S, Goh W, Quek R, Chan JC, Leung AK, Ngan R
    • Organizer
      The European Society for Medical Oncology Asia 2016 Annual Meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Immunotherapy targeting NY-ESO-1 for sarcomas2016

    • Author(s)
      Endo M
    • Organizer
      The 21st Annual Scientific Symposium of the Hong Kong Cancer Institute
    • Place of Presentation
      Hong Kong
    • Year and Date
      2016-11-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CIC-rearranged sarcomas: clinical features and treatment outcome2016

    • Author(s)
      Endo M, Yoshida A, Kobayashi E, Toki S, Hirose T, Uehara T, Sugawara M, Mori T, Shimizu K, Tanzawa Y, Nakatani F, Chuman H, Kawai A.
    • Organizer
      The 21th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Lisbon, Portuguel
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinicopathological findings and treatment results of BCOR-CCNB3 sarcoma2016

    • Author(s)
      Sugawara M, Endo M, Yoshida A, Kobayashi E, Tanzawa Y, Nakatani F, Takagi M, Chuman H, Kawai A
    • Organizer
      The 21th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Lisbon, Portuguel
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of a possible therapeutic candidate for advanced chondrosarcoma with an IDH1 mutant inhibitor2016

    • Author(s)
      Nakagawa M, Nakatani F, Endo M, Kobayashi E, Tanzawa Y, Kawai A, Chuman H, Yoshida A, Seki T, Araki K, Iwamoto Y, Kitabayashi I
    • Organizer
      The 21th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Lisbon, Portuguel
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A refractory desmoid-type fibromatosis with a remarkable response to pazopanib Treatment2016

    • Author(s)
      Kobayashi E, Endo M, Tanzawa Y, Nakatani F, Chuman H, Kawai A
    • Organizer
      The 21th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Lisbon, Portuguel
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanisim of pazopanib resistance in synovial sarcoma.2016

    • Author(s)
      Matsumoto Y, Yokoyama N, Matsunobu T, Endo M, Setsu N, Iida K, Fukushima S, Iwamoto Y.
    • Organizer
      The 21th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Lisbon, Portuguel
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Treatment of bone and soft-tissue sarcoma patients in Japan; the distribution of patients and medical specialties by cancer topography and treatment modality2016

    • Author(s)
      Endo M, Iwamoto M, Toki S, Hirose T, Uehara T, Sugawara M, Mori T, Shimizu K, Kobayashi E, Tanzawa Y, Nakatani F, Chuman H, Higashi T, Kawai A.
    • Organizer
      The 21th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Lisbon, Portuguel
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical features, treatment and prognosis of angiosarcoma involving the spine.2016

    • Author(s)
      Hirose T, Endo M, Yoshida A, Nakano R, Toki S, Uehara T, Sugawara M, Araki Y, Mori T, Shimizu K, Kobayashi E, Tanzawa Y, Nakatani F, Chuman H, Kawai A
    • Organizer
      The 21th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Lisbon, Portuguel
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 悪性末梢神経鞘腫瘍に対する低酸素誘導因子阻害剤の有効性の検討2016

    • Author(s)
      福島俊、松本嘉寛、中川亮、横山信彦、鍋島央、畑野美穂子、遠藤誠、松延知哉、福士純一、播广谷勝三、小田義直、岩本幸英
    • Organizer
      第49回日本整形外科学会 骨軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 滑膜肉腫細胞株におけるパゾパニブへの獲得耐性メカニズムの検討2016

    • Author(s)
      横山信彦、松延知哉、福島俊、鍋島央、畑野美穂子、遠藤誠、松本嘉寛、福士純一、播广谷勝三、岩本幸英
    • Organizer
      第49回日本整形外科学会 骨軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 軟部肉腫81例におけるpazopanibの使用経験2016

    • Author(s)
      小林英介, 薛宇孝, 清水光樹, 菅原正登, 荒木麗博, 森智章, 中谷文彦, 遠藤誠, 丹沢義一, 川井章, 中馬広一
    • Organizer
      第49回日本整形外科学会 骨軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん精巣抗原NY-ESO-1の骨腫瘍における発現2016

    • Author(s)
      遠藤誠, 小林英介, 丹澤義一, 中谷文彦, 川井章, 中馬広一, Nielsen Torsten
    • Organizer
      第89回日本整形外科学会 学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Forty-eight cases of Leiomyosarcoma of Bone in Japan: A Multicenter Study from the Japanese Musculoskeletal Oncology Group2016

    • Author(s)
      Mori T, Nakayama R, Endo M, Kobayashi E, Kawai A, Ueda T, Morioka H
    • Organizer
      The 11th Asia Pacific Musculoskeletal Tumour Society Meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Malignant glomus tumour treated with pazopanib.2015

    • Author(s)
      Endo M, Bekki H, Kobayashi E, Tanzawa Y, Nakatani F, Kawai A, Chuman H, Oda Y, Iwamoto Y
    • Organizer
      The European Society for Medical Oncology Asia 2015 Annual Meeting
    • Place of Presentation
      Singapore
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PTEN Expression Is A Good Prognostic Marker In Malignant Peripheral Nerve Sheath Tumors.2015

    • Author(s)
      M. Endo, N. Setsu, E. Kobayashi, Y. Tanzawa, F. Nakatani, A. Kawai, H. Chuman, M. Hakozaki, K. Kohashi, H. Yamamoto, Y. Oda, T. Matsunobu, Y. Matsumoto, K. Harimaya, Y. Iwamoto.
    • Organizer
      The 20th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multi-targeted Tyrosine Kinase Inhibitors For Alveolar Soft Part Sarcomas.2015

    • Author(s)
      Eisuke Kobayashi, Makoto Endo, Yoshikazu Tanzawa, Fumihiko Nakatani, Hirokazu Chuman, Akira Kawai
    • Organizer
      The 20th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Angiomatoid Fibrous Histiocytoma: A Report Of Eight Cases.2015

    • Author(s)
      Yoshihiro Araki, Eisuke Kobayashi, Makoto Endo, Yoshikazu Tanzawa, Fumihiko Nakatani, Akira Kawai, Hirokazu Chuman
    • Organizer
      The 20th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploratory research for prognostic factors and novel therapeutic targets in bone and soft tissue tumors.2015

    • Author(s)
      Endo M
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A pelvic tumor.2015

    • Author(s)
      Oda Y, Yamamoto H, Kohashi K, Endo M
    • Organizer
      The International Skeletal Society 42nd Annual Meeting
    • Place of Presentation
      Maui, USA
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Safety and efficiency of salvage chemotherapy with ifosfamide, carboplatin and etoposide for malignant bone and soft tissue tumors.2015

    • Author(s)
      Endo M, Hirose T, Matsunobu T, Matsumoto Y, Harimaya K, Tamura S, Kusaba H, Oda Y, Iwamoto Y.
    • Organizer
      The Japanese Society of Medical Oncology 2015 Annual Meeting
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Safety and efficiency of chemotherapy with ifosfamide, carboplatin and etoposide for bone and soft tissue sarcomas2015

    • Author(s)
      Endo M, Hirose T, Matsumoto Y, Matsunobu T, Harimaya K, Oda Y, Iwamoto Y.
    • Organizer
      The 88th Annual Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical outcome of primary leiomyosarcoma of bone(LMSOB): A multicenter study in Japan.2015

    • Author(s)
      Mori T, Endo M, Fukase N, Hiraga H, Tomita M, Kobayashi E, Shinoda Y, Ueda T, Morioka H, Toyama Y
    • Organizer
      The 88th Annual Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation Status of AKT-mTOR and MAPK Pathways in Malignant Peripheral Nerve Sheath Tumors: Which Pathway Affects a Patient’s Survival?2014

    • Author(s)
      Endo M, Setsu N, Kohashi K, Yamamoto H, Matsunobu T, Matsumoto Y, Harimaya K, Iwamoto Y, Oda Y.
    • Organizer
      The 19th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ifosfamide, Carboplatin, and Etoposide (ICE) for Metastatic or Refractory Bone and Soft Tissue Sarcomas2014

    • Author(s)
      Hirose T, Endo M, Matsumoto Y, Matsunobu T, Harimaya K, Oda Y, Iwamoto Y.
    • Organizer
      The 19th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性末梢神経鞘腫瘍におけるPTENの発現解析と予後的意義の検討2014

    • Author(s)
      遠藤誠、薛宇孝、箱崎道之、戸次大史、井浦国生、前川啓、石井武彰、高橋祐介、山田裕一、孝橋賢一、山元英崇、松延知哉、松本嘉寛、播广谷勝三、岩本幸英、小田義直
    • Organizer
      第47回日本整形外科学会 骨軟部腫瘍学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-17 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 悪性骨腫瘍に対するsecond line化学療法としてのifosfamide, carboplatin, etoposide併用療法(ICE療法)の安全性と有効性の検討2014

    • Author(s)
      廣瀬毅、遠藤誠、松本嘉寛、松延知哉、播广谷勝三、小田義直、岩本幸英
    • Organizer
      第47回日本整形外科学会 骨軟部腫瘍学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-17 – 2014-07-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨・軟部腫瘍を含む間葉系腫瘍におけるMCL1およびBCL2タンパク発現の網羅的解析2014

    • Author(s)
      遠藤誠、松延知哉、松本嘉寛、播广谷勝三、Nielsen TO、小田義直、岩本幸英
    • Organizer
      第87回日本整形外科学会 学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2014-05-22 – 2014-05-25
    • Related Report
      2014 Annual Research Report
  • [Remarks] 九州大学 研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K004977/index.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2020-03-30  

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